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Human mitochondrial branched chain aminotransferase isozyme: Structural role of the CXXC center in catalysis (2006)
Journal Article

Mammalian branched chain aminotransferases (BCATs) have a unique CXXC center. Kinetic and structural studies of three CXXC center mutants (C315A, C318A, and C315A/C318A) of human mitochondrial (hBCATm) isozyme and the oxidized hBCATm enzyme (hBCATm-O... Read More about Human mitochondrial branched chain aminotransferase isozyme: Structural role of the CXXC center in catalysis.

Regulation of smooth muscle cell proliferation by β-catenin/T-cell factor signaling involves modulation of cyclin D1 and p21 expression (2006)
Journal Article

We previously observed that stimulation of vascular smooth muscle cell (VSMC) proliferation with growth factors is associated with dismantling of cadherin junctions and nuclear translocation of β-catenin. In this study we demonstrate directly that gr... Read More about Regulation of smooth muscle cell proliferation by β-catenin/T-cell factor signaling involves modulation of cyclin D1 and p21 expression.

Some effects of nitrogen nutrition on caesium uptake and translocation by species in the Poaceae, Asteraceae and Caryophyllidae (2006)
Journal Article

There is current interest in managing and manipulating 137Cs transfer from soil to plants. We hypothesized that N source might affect Cs uptake by plants and report experiments that confirm this. Uptake experiments using hydroponics with a variety of... Read More about Some effects of nitrogen nutrition on caesium uptake and translocation by species in the Poaceae, Asteraceae and Caryophyllidae.

Presence of WT1 in nuclear messenger RNP particles in the human acute myeloid leukemia cell lines HL60 and K562 (2006)
Journal Article

The WT1 gene is a key player in acute myeloid leukaemia, in which it is frequently over-expressed. WT1 encodes a multifunctional zinc finger protein transcription factor, which also binds mRNA. Thus increasing evidence suggests that WT1 works both at... Read More about Presence of WT1 in nuclear messenger RNP particles in the human acute myeloid leukemia cell lines HL60 and K562.

WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo (2006)
Journal Article

Wilm's tumor protein 1 (WT1), a protein implicated in various cancers and developmental disorders, consists of two major isoforms: WT1(-KTS), a transcription factor, and WT1(+KTS), a post-transcriptional regulator that binds to RNA and can interact w... Read More about WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo.

Relationship between the expression of hepatic but not testicular 3β-hydroxysteroid dehydrogenase with androstenone deposition in pig adipose tissue (2006)
Journal Article

This study investigated the relationship between expression of hepatic and testicular 3/3-hydroxysteroid dehydrogenase (3/3-HSD) and accumulation of androstenone in adipose tissue because of its relation to boar taint. The experiments were performed... Read More about Relationship between the expression of hepatic but not testicular 3β-hydroxysteroid dehydrogenase with androstenone deposition in pig adipose tissue.

Production of reactive oxygen species and reactive nitrogen species by angiosperm stigmas and pollen: Potential signalling crosstalk? (2006)
Journal Article

• Angiosperm stigmas exhibit high levels of peroxidase activity when receptive to pollen. To explore possible function(s) of this peroxidase activity we investigated amounts of reactive oxygen species (ROS), particularly hydrogen peroxide, in stigmas... Read More about Production of reactive oxygen species and reactive nitrogen species by angiosperm stigmas and pollen: Potential signalling crosstalk?.

The Wilms tumour suppressor protein WT1 (+KTS isoform) binds alpha-actinin 1 mRNA via its zinc-finger domain (2006)
Journal Article

Mutations in WT1 are associated with developmental syndromes that affect the urogenital system and neoplasms, including Wilms tumour, acute myeloid leukemia, and breast and prostate cancers. The WT1 protein belongs to the early growth response family... Read More about The Wilms tumour suppressor protein WT1 (+KTS isoform) binds alpha-actinin 1 mRNA via its zinc-finger domain.

N-cadherin and b-catenin signalling regulates vascular smooth muscle cell proliferation and cell cycle genes (2006)
Journal Article

Vascular smooth muscle cell (VSMC) proliferation is a key event in the pathogenesis of vascular diseases. Dismantling of cadherin junctions and translocation of b-catenin to the cytoplasm occurs in proliferating VSMCs. To determine whether N-cadherin... Read More about N-cadherin and b-catenin signalling regulates vascular smooth muscle cell proliferation and cell cycle genes.

Ethylene-induced stomatal closure in Arabidopsis occurs via AtrbohF-mediated hydrogen peroxide synthesis (2006)
Journal Article

Ethylene is a plant hormone that regulates many aspects of growth and development. Despite the well-known association between ethylene and stress signalling, its effects on stomatal movements are largely unexplored. Here, genetic and physiological da... Read More about Ethylene-induced stomatal closure in Arabidopsis occurs via AtrbohF-mediated hydrogen peroxide synthesis.

Evidence for declining levels of heavy-metals in the Severn Estuary and Bristol Channel, U.K. and their spatial distribution in sediments (2006)
Journal Article

Levels of heavy-metals (Cd, Cu, Cr, Ni, Pb and Zn) in suspended particulate and in surface and subsurface sediments were determined at seven locations in the Severn Estuary and Bristol Channel. Sediment metal concentrations were highest at sites clos... Read More about Evidence for declining levels of heavy-metals in the Severn Estuary and Bristol Channel, U.K. and their spatial distribution in sediments.