Skip to main content

Research Repository

Advanced Search

All Outputs (5)

Development of a three-dimensional in-vitro model of the human bone marrow using commercially available matrices and bone marrow derived mesenchymal stem cells/HS-5 stromal cell line (2016)
Thesis
Kabrah, S. Development of a three-dimensional in-vitro model of the human bone marrow using commercially available matrices and bone marrow derived mesenchymal stem cells/HS-5 stromal cell line. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/10596716

The function of the bone marrow is known to be affected by both haematopoietic malignancies as well as the chemotherapy used to treat them. To appropriately evaluate the role of disease versus treatment, this study aimed to develop a novel three-dime... Read More about Development of a three-dimensional in-vitro model of the human bone marrow using commercially available matrices and bone marrow derived mesenchymal stem cells/HS-5 stromal cell line.

Investigations on potential digenic HAMP(hepcidin) and HFE haemochromatosis gene mutations in the development of iron overload in Irish patients with dilated cardiomyopathy (2016)
Thesis
Jereza, N. Investigations on potential digenic HAMP(hepcidin) and HFE haemochromatosis gene mutations in the development of iron overload in Irish patients with dilated cardiomyopathy. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/911991

Iron overload cardiomyopathy (IOC) has been recently described as a dilated cardiomyopathy, characterized by left ventricular (LV) remodelling with chamber dilatation and reduced LV ejection fraction (LVEF). However, primary haemochromatosis, a genet... Read More about Investigations on potential digenic HAMP(hepcidin) and HFE haemochromatosis gene mutations in the development of iron overload in Irish patients with dilated cardiomyopathy.

Development of generic methods for the analysis and purification of polar compounds by high performance liquid chromatography (2016)
Thesis
Russell, J. J. (in press). Development of generic methods for the analysis and purification of polar compounds by high performance liquid chromatography. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/914251

Generic methods were developed using different columns for analysis and purification of hydrophilic compounds by hydrophilic interaction chromatography (HILIC). Mobile phases were investigated in detail, and across each column chemistry tested (BEH A... Read More about Development of generic methods for the analysis and purification of polar compounds by high performance liquid chromatography.

The molecular epidemiology of ampC-mediated resistance in Escherichia coli: A study of clinical strains isolated from the South West region (2016)
Thesis
Lewis, J. (in press). The molecular epidemiology of ampC-mediated resistance in Escherichia coli: A study of clinical strains isolated from the South West region. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/915314

Escherichia coli is a common human pathogen, capable of causing a wide range of infections. Some strains produce AmpC beta-lactamase, an enzyme able to affect the action of antibiotics. These strains are often resistant to cephalosporin antibiotics,... Read More about The molecular epidemiology of ampC-mediated resistance in Escherichia coli: A study of clinical strains isolated from the South West region.