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Toxicity testing: The search for an in vitro alternative to animal testing (2009)
Journal Article
May, J. E., Xu, J., Morse, R., Avent, N. D., & Donaldson, C. (2009). Toxicity testing: The search for an in vitro alternative to animal testing. British Journal of Biomedical Science, 66(3), 160-165. https://doi.org/10.1080/09674845.2009.11730265

Prior to introduction to the clinic, pharmaceuticals must undergo rigorous toxicity testing to ensure their safety. Traditionally, this has been achieved using in vivo animal models. However, besides ethical reasons, there is a continual drive to red... Read More about Toxicity testing: The search for an in vitro alternative to animal testing.

New insights into the function of the Wilms tumor suppressor gene WT1 in podocytes (2008)
Journal Article
Morrison, A. A., Viney, R. L., Saleem, M. A., & Ladomery, M. (2008). New insights into the function of the Wilms tumor suppressor gene WT1 in podocytes. AJP - Renal Physiology, 295(1), F12-F17. https://doi.org/10.1152/ajprenal.00597.2007

The Wilms tumor suppressor gene WT1 is essential for early urogenital development: homozygous mutations in WT1 result in embryonic lethality due to a failure in the development of kidneys and gonads. In the adult kidney, WT1 expression is limited to... Read More about New insights into the function of the Wilms tumor suppressor gene WT1 in podocytes.

The post-transcriptional roles of WT1, a multifunctional zinc-finger protein (2008)
Journal Article
Morrison, A. A., Viney, R. L., & Ladomery, M. (2008). The post-transcriptional roles of WT1, a multifunctional zinc-finger protein. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1785(1), 55-62. https://doi.org/10.1016/j.bbcan.2007.10.002

WT1 was first described in 1990 as a tumour suppressor gene associated with Wilms tumour (nephroblastoma). It encodes a typical transcription factor with four C2-H2 zinc fingers in the C-terminus. However WT1 is surprisingly complex at multiple level... Read More about The post-transcriptional roles of WT1, a multifunctional zinc-finger protein.

Nitric oxide synthesis and signalling in plants (2008)
Journal Article
Neill, S. J., Wilson, I. D., & Hancock, J. T. (2008). Nitric oxide synthesis and signalling in plants. Plant, Cell and Environment, 31(5), 622-631. https://doi.org/10.1111/j.1365-3040.2007.01761.x

As with all organisms, plants must respond to a plethora of external environmental cues. Individual plant cells must also perceive and respond to a wide range of internal signals. It is now well-accepted that nitric oxide (NO) is a component of the r... Read More about Nitric oxide synthesis and signalling in plants.

Chapter 23 Screen-printed electrochemical (bio)sensors in biomedical, environmental and industrial applications (2007)
Journal Article
Hart, J. P., Crew, A., Crouch, E., Honeychurch, K. C., & Pemberton, R. (2007). Chapter 23 Screen-printed electrochemical (bio)sensors in biomedical, environmental and industrial applications. https://doi.org/10.1016/S0166-526X%2806%2949023-1

This chapter describes a number of approaches for the fabrication of prototype screen-printed electrochemical (bio) sensors together with selected applications in the areas of biomedical, environmental and industrial analyses. Novel methods of immobi... Read More about Chapter 23 Screen-printed electrochemical (bio)sensors in biomedical, environmental and industrial applications.

Fluorescence analysis of dissolved organic matter in natural, waste and polluted waters - A review (2007)
Journal Article
Hudson, N., Baker, A., & Reynolds, D. M. (2007). Fluorescence analysis of dissolved organic matter in natural, waste and polluted waters - A review. River Research and Applications, 23(6), 631-649. https://doi.org/10.1002/rra.1005

Dissolved organic matter (DOM) in aquatic systems originates from a range of sources. Some is allochthonous, transported from the surrounding landscape to the water body, and is derived from and influenced by the geology, land use and hydrology of it... Read More about Fluorescence analysis of dissolved organic matter in natural, waste and polluted waters - A review.

American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer (2007)
Journal Article
Press, M. F., Wolff, A. C., Hammond, M. E. H., Schwartz, J. N., Hagerty, K. L., Allred, D. C., …Hayes, D. F. (2007). American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer. Journal of Clinical Oncology, 25(1), 118-145. https://doi.org/10.1200/JCO.2006.09.2775

Purpose: To develop a guideline to improve the accuracy of human epidermal growth factor receptor 2 (HER2) testing in invasive breast cancer and its utility as a predictive marker. Methods: The American Society of Clinical Oncology and the College of... Read More about American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer.

Bone marrow-derived mesenchymal stem cells (2005)
Journal Article
Hows, J., Kemp, K. C., & Donaldson, C. (2005). Bone marrow-derived mesenchymal stem cells. Leukemia & Lymphoma, 46(11), 1531-1544. https://doi.org/10.1080/10428190500215076

Human mesenchymal stem cells (MSCs) contribute to the regeneration of mesenchymal tissues, and are essential in providing support for the growth and differentiation of primitive hemopoietic cells within the bone marrow micro-environment. Techniques a... Read More about Bone marrow-derived mesenchymal stem cells.

Development of an siRNA-based method for repressing specific genes in renal organ culture and its use to show that the Wt1 tumour suppressor is required for nephron differentiation (2004)
Journal Article
Davies, J. A., Ladomery, M., Hohenstein, P., Michael, L., Shafe, A., Spraggon, L., & Hastie, N. (2004). Development of an siRNA-based method for repressing specific genes in renal organ culture and its use to show that the Wt1 tumour suppressor is required for nephron differentiation. Human Molecular Genetics, 13(2), 235-246. https://doi.org/10.1093/hmg/ddh015

Wt1 is a tumour suppressor gene, mutation of which is a cause of Wilms' tumour, a childhood renal nephroblastoma. Wt1 is expressed in a rich pattern during renal development suggesting that it acts at three stages: determination of the kidney area, t... Read More about Development of an siRNA-based method for repressing specific genes in renal organ culture and its use to show that the Wt1 tumour suppressor is required for nephron differentiation.

The formation of voronoi diagrams in chemical and physical systems: Experimental findings and theoretical models (2004)
Journal Article
Purwins, H. G., de Lacy Costello, B., Ratcliffe, N. M., Adamatzky, A., Zanin, A. L., & Liehr, A. W. (2004). The formation of voronoi diagrams in chemical and physical systems: Experimental findings and theoretical models. International Journal of Bifurcation and Chaos, 14(7), 2187-2210. https://doi.org/10.1142/S021812740401059X

The work discusses the formation of Voronoi diagrams in spatially extended nonlinear systems taking experimental and theoretical results into account. Concerning experimental systems a number of chemical systems used previously as prototype chemical... Read More about The formation of voronoi diagrams in chemical and physical systems: Experimental findings and theoretical models.

Murine Denys-Drash syndrome: Evidence of podocyte de-differentiation and systemic mediation of glomerulosclerosis (2003)
Journal Article
Hastie, N. D., Fleming, S., Patek, C. E., Miles, C. G., Bellamy, C. O., Ladomery, M., …Hooper, M. L. (2003). Murine Denys-Drash syndrome: Evidence of podocyte de-differentiation and systemic mediation of glomerulosclerosis. Human Molecular Genetics, 12(18), 2379-2394. https://doi.org/10.1093/hmg/ddg240

Denys-Drash syndrome (DDS) is caused by dominant mutations of the Wilms' tumour suppressor gene, WT1, and characterized by a nephropathy involving diffuse mesangial sclerosis, male pseudohermaphroditism and/ or Wilms' tumourigenesis. Previously, we r... Read More about Murine Denys-Drash syndrome: Evidence of podocyte de-differentiation and systemic mediation of glomerulosclerosis.

Nitric oxide signalling in plants (2003)
Journal Article
Neill, S., Desikan, R., & Hancock, J. T. (2003). Nitric oxide signalling in plants. New Phytologist, 159(1), 11-35. https://doi.org/10.1046/j.1469-8137.2003.00804.x

Recently nitric oxide (NO) has emerged as a key signalling molecule in plants. Here we review the potential sources of endogenous NO, outline the biological processes likely to be mediated by NO, and discuss the downstream signalling processes by whi... Read More about Nitric oxide signalling in plants.

Expression in Xenopus oocytes shows that WT1 binds transcripts in vivo, with a central role for zinc finger one (2003)
Journal Article
Ladomery, M., Sommerville, J., Woolner, S., Slight, J., & Hastie, N. (2003). Expression in Xenopus oocytes shows that WT1 binds transcripts in vivo, with a central role for zinc finger one. Journal of Cell Science, 116(8), 1539-1549. https://doi.org/10.1242/jcs.00324

The Wilms' tumour suppressor gene WT1 encodes a protein involved in urogenital development and disease. The salient feature of WT1 is the presence of four 'Krüppel'-type C2-H2 zinc fingers in the C-terminus. Uniquely to WTI, an evolutionarily conserv... Read More about Expression in Xenopus oocytes shows that WT1 binds transcripts in vivo, with a central role for zinc finger one.

Soil availability, plant uptake and soil to plant transfer of 99Tc - A review (2003)
Journal Article
Bennett, R., & Willey, N. (2003). Soil availability, plant uptake and soil to plant transfer of 99Tc - A review. Journal of Environmental Radioactivity, 65(2), 215-231. https://doi.org/10.1016/S0265-931X%2802%2900098-X

The fission yield of 99Tc from 239Pu and 235U is similar to that of 137Cs or 90Sr and it is therefore an important component of nuclear weapons fall-out, nuclear waste and releases from nuclear facilities. There is particular current interest in 99Tc... Read More about Soil availability, plant uptake and soil to plant transfer of 99Tc - A review.

Identifying bacteria in human urine: Current practice and the potential for rapid, near-patient diagnosis by sensing volatile organic compounds (2001)
Journal Article
Howe, R. A., Spencer-Phillips, P. T., Ratcliffe, N. M., Guernion, N., Ratcliffe, N. M., Spencer-Phillips, P. T., & Howe, R. (2001). Identifying bacteria in human urine: Current practice and the potential for rapid, near-patient diagnosis by sensing volatile organic compounds. Clinical Chemistry and Laboratory Medicine, 39(10), 893-906. https://doi.org/10.1515/CCLM.2001.146

Urinary tract infection (UTI) represents a significant burden for the National Health Service. Extensive research has been directed towards rapid detection of UTI in the last thirty years. A wide range of microbiological and chemical techniques are n... Read More about Identifying bacteria in human urine: Current practice and the potential for rapid, near-patient diagnosis by sensing volatile organic compounds.

Transcription and masking of mRNA in germ cells: Involvement of Y-box proteins (1996)
Journal Article
Sommerville, J., & Ladomery, M. (1996). Transcription and masking of mRNA in germ cells: Involvement of Y-box proteins. Chromosoma, 104(7), 469-478. https://doi.org/10.1007/BF00352111

Gametogenesis is directed by various specialized genetic mechanisms which, to a considerable extent, apply to the production of both eggs and sperm and have been conserved across a wide spectrum of eukaryotic organisms. Two key aspects which are disc... Read More about Transcription and masking of mRNA in germ cells: Involvement of Y-box proteins.

Proximate composition at various stages of adult life in the Southern Hemisphere lamprey, Geotria australis gray (1983)
Journal Article
Bird, D. J., & Potter, I. C. (1983). Proximate composition at various stages of adult life in the Southern Hemisphere lamprey, Geotria australis gray. Comparative Biochemistry and Physiology - A: Comparative Physiology, 74(3), 623-633. https://doi.org/10.1016/0300-9629%2883%2990557-1

1. 1. At the end of the marine trophic phase in Geotria australis, the lipid content (as % wet body weight) was very high in the whole animal (21%) and in the liver (38-40%). 2. 2. During the very long spawning-run period (ca 16 months), vast changes... Read More about Proximate composition at various stages of adult life in the Southern Hemisphere lamprey, Geotria australis gray.