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Hybridization Between Brassica napus and B. rapa on a National Scale in the United Kingdom (2003)
Journal Article
Shaw, M. W., Wilkinson, M. J., Elliott, L. J., Allainguillaume, J., Norris, C., Welters, R., …Mason, D. C. (2003). Hybridization Between Brassica napus and B. rapa on a National Scale in the United Kingdom. Science, 302(5644), 457-459. https://doi.org/10.1126/science.1088200

Measures blocking hybridization would prevent or reduce biotic or environmental change caused by gene flow from genetically modified (GM) crops to wild relatives. The efficacy of any such measure depends on hybrid numbers within the legislative regio... Read More about Hybridization Between Brassica napus and B. rapa on a National Scale in the United Kingdom.

Site of intracellular expression of ß-catenin influences the outcome in sporadic colorectal cancer (2003)
Journal Article
Sivakumar, R., Elder, J., Greenhough, A., Lacy-Colson, J., Jones, P., Hall, C., …Elder, J. (2003). Site of intracellular expression of ß-catenin influences the outcome in sporadic colorectal cancer. European Journal of Cancer, 1(5), S84. https://doi.org/10.1016/S1359-6349%2803%2990306-5

Background: Stabilisation and nuclear translocation of beta-catenin are suggested to be the early events in the colorectal carcinogenesis. Nuclear accumulation of beta-catenin was associated with high-grade tumour and increased cell proliferation in... Read More about Site of intracellular expression of ß-catenin influences the outcome in sporadic colorectal cancer.

British newspapers priviledge health and medicine topics over other science news (2003)
Journal Article
Weitkamp, E. (2003). British newspapers priviledge health and medicine topics over other science news. Public Relations Review, 29(3), 321-333. https://doi.org/10.1016/S0363-8111%2803%2900041-9

This study examines coverage of science, health and medicine in five UK national newspapers: three broadsheets, a mid-sheet and a tabloid. The content analysis is compared with a quantitative survey of members of the Association of British Science Wr... Read More about British newspapers priviledge health and medicine topics over other science news.

The synthesis of novel 3-substituted pyrrole monomers possessing chiral side groups: A study of their chemical polymerisation and the assessment of their chiral discrimination properties (2003)
Journal Article
de Lacy Costello, B., Ratcliffe, N. M., & Sivanand, P. S. (2003). The synthesis of novel 3-substituted pyrrole monomers possessing chiral side groups: A study of their chemical polymerisation and the assessment of their chiral discrimination properties. Synthetic Metals, 139(1), 43-55. https://doi.org/10.1016/S0379-6779%2802%2901247-X

Novel 3-substituted pyrrole monomers possessing chiral side groups were synthesised. These compounds were successfully polymerised with ferric salts and the polymer materials fabricated into sensors. The sensors were found to elicit differential chan... Read More about The synthesis of novel 3-substituted pyrrole monomers possessing chiral side groups: A study of their chemical polymerisation and the assessment of their chiral discrimination properties.

Rationalization of retention and overloading behavior of basic compounds in reversed-phase HPLC using low ionic strength buffers suitable for mass spectrometric detection (2003)
Journal Article
McCalley, D. V. (2003). Rationalization of retention and overloading behavior of basic compounds in reversed-phase HPLC using low ionic strength buffers suitable for mass spectrometric detection. Analytical Chemistry, 75(14), 3404-3410. https://doi.org/10.1021/ac020715f

The retention and overloading behavior of some basic (and acidic) compounds has been studied on different RP-HPLC columns in buffers of varying ionic strength. Anomalous retention patterns of acids and bases were found on one phase in low-pH, volatil... Read More about Rationalization of retention and overloading behavior of basic compounds in reversed-phase HPLC using low ionic strength buffers suitable for mass spectrometric detection.

Experimental reaction-diffusion chemical processors for robot path planning (2003)
Journal Article
Adamatzky, A., de Lacy Costello, B., Ratcliffe, N. M., & Melhuish, C. (2003). Experimental reaction-diffusion chemical processors for robot path planning. Journal of Intelligent and Robotic Systems, 37(3), 233-249. https://doi.org/10.1023/A%3A1025414424756

In this paper we discuss the experimental implementation of a chemical reaction-diffusion processor for robot motion planning in terms of finding the shortest collision-free path for a robot moving in an arena with obstacles. These reaction-diffusion... Read More about Experimental reaction-diffusion chemical processors for robot path planning.

Thick film organic vapour sensors based on binary mixtures of metal oxides (2003)
Journal Article
Ewen, R. J., de Lacy Costello, B., Ratcliffe, N. M., & Sivanand, P. S. (2003). Thick film organic vapour sensors based on binary mixtures of metal oxides. Sensors and Actuators B: Chemical, 92(1-2), 159-166. https://doi.org/10.1016/S0925-4005%2803%2900258-2

Previously, composite sensors incorporating differing proportions of tin dioxide and zinc oxide were reported which exhibited high sensitivity to a range of organic vapours under dry conditions (0% relative humidity, RH). Most importantly, the compos... Read More about Thick film organic vapour sensors based on binary mixtures of metal oxides.

Irrationality, suboptimality, and the evolutionary context (2003)
Journal Article
Cuthill, I., & Steer, M. (2003). Irrationality, suboptimality, and the evolutionary context. Behavioral and Brain Sciences, 26(2), 176-177. https://doi.org/10.1017/S0140525X03460056

We propose that a direct analogy can be made between optimal behaviour in animals and rational behaviour in humans, and that lessons learned by the study of the former can be applied to the latter. Furthermore, we suggest that, to understand human de... Read More about Irrationality, suboptimality, and the evolutionary context.

A prototype sensor system for the early detection of microbially linked spoilage in stored wheat grain (2003)
Journal Article
de Lacy Costello, B., Ewen, R., Gunson, H., Ratcliffe, N. M., Sivanand, P., & Spencer-Phillips, P. T. (2003). A prototype sensor system for the early detection of microbially linked spoilage in stored wheat grain. Measurement Science and Technology, 14(4), 397-409. https://doi.org/10.1088/0957-0233/14/4/301

Spencer-Phillips was Co-Investigator, the lead biologist in this HGCA-funded multi-disciplinary work, and co-wrote the paper. The grant was based on his expertise in the microbiology of post-harvest spoilage.

Adult bone marrow is a rich source of human mesenchymal 'stem' cells but umbilical cord and mobilized adult blood are not (2003)
Journal Article
Wexler, S. A., Donaldson, C., Denning-Kendall, P., Rice, C., Bradley, B., & Hows, J. M. (2003). Adult bone marrow is a rich source of human mesenchymal 'stem' cells but umbilical cord and mobilized adult blood are not. British Journal of Haematology, 121(2), 368-374. https://doi.org/10.1046/j.1365-2141.2003.04284.x

In postnatal life, mesenchymal stem cells (MSC) self-replicate, proliferate and differentiate into mesenchymal tissues, including bone, fat, tendon, muscle and bone marrow (BM) stroma. Possible clinical applications for MSC in stem cell transplantati... Read More about Adult bone marrow is a rich source of human mesenchymal 'stem' cells but umbilical cord and mobilized adult blood are not.

Uptake of 134Cs by four species from the Asteraceae and two varieties from the Chenopodiaceae grown in two types of Chinese soil (2003)
Journal Article
Willey, N. J., & Tang, S. (2003). Uptake of 134Cs by four species from the Asteraceae and two varieties from the Chenopodiaceae grown in two types of Chinese soil. Plant and Soil, 250(1), 75-81. https://doi.org/10.1023/A%3A1022873930771

This study investigated the uptake of 134Cs by Lactuca sativa L., Silybum marianum Gaertn., Centaurea cyanus L., Carthamus tinctorius L. from the Asteraceae, and Beta vulgaris L. var. 'Lutiancai' and Beta vulgaris L. var. 'Hongtiancai' from the Cheno... Read More about Uptake of 134Cs by four species from the Asteraceae and two varieties from the Chenopodiaceae grown in two types of Chinese soil.

Syntheses and polymerizations of (E)-2-styrylfurans and an investigation of their electrorheological properties (2003)
Journal Article
Ewen, R. J., Teare, G. C., Campbell, S. A., Ratcliffe, N. M., & Smith, J. R. (2003). Syntheses and polymerizations of (E)-2-styrylfurans and an investigation of their electrorheological properties. Smart Materials and Structures, 12(1), 129-138. https://doi.org/10.1088/0964-1726/12/1/315

Novel furan compounds, which incorporate phenyl rings separated by alkene spacers, have been synthesized. Chemical polymerization of these compounds yielded black brittle powders, suspensions of which were found to exhibit significant electrorheologi... Read More about Syntheses and polymerizations of (E)-2-styrylfurans and an investigation of their electrorheological properties.

Human mitochondrial and cytosolic branched-chain aminotransferases are cysteine S-conjugate β-lyases, but turnover leads to inactivation (2003)
Journal Article
Cooper, A. J. L., Bruschi, S. A., Conway, M., & Hutson, S. M. (2003). Human mitochondrial and cytosolic branched-chain aminotransferases are cysteine S-conjugate β-lyases, but turnover leads to inactivation. Biochemical Pharmacology, 65(2), 181-192. https://doi.org/10.1016/S0006-2952%2802%2901513-7

The mitochondrial and cytosolic branched-chain aminotransferases (BCATm and BCATc) are homodimers in the fold type IV class of pyridoxal 5′-phosphate-containing enzymes that also contains D-amino acid aminotransferase and 4-amino-4-deoxychorismate ly... Read More about Human mitochondrial and cytosolic branched-chain aminotransferases are cysteine S-conjugate β-lyases, but turnover leads to inactivation.

Topology: A novel method to describe branching patterns in Peronospora viciae colonies (2003)
Journal Article
Johnston, M. A., Ott, A., Spencer-Phillips, P. T., & Willey, N. (2003). Topology: A novel method to describe branching patterns in Peronospora viciae colonies. Mycological Research, 107(10), 1123-1131. https://doi.org/10.1017/S0953756203008384

Topology provides a novel means to describe branching patterns and has not been applied to fungal colonies previously. For any branched structure, various topologies are possible, and these lie between two extremes, a herringbone pattern (main axis w... Read More about Topology: A novel method to describe branching patterns in Peronospora viciae colonies.

Screen-printed electrochemical sensors for monitoring metal pollutants (2003)
Journal Article
Honeychurch, K. C., & Hart, J. P. (2003). Screen-printed electrochemical sensors for monitoring metal pollutants. Trends in Analytical Chemistry, 22(7), 456-469. https://doi.org/10.1016/S0165-9936%2803%2900703-9

This review describes current developments in the design and fabrication of disposable screen-printed sensors for the electrochemical determination of trace metals in biological, environmental and industrial samples. Specific emphasis is placed on se... Read More about Screen-printed electrochemical sensors for monitoring metal pollutants.

Rapid and direct determination of tryptophan in water using synchronous fluorescence spectroscopy (2003)
Journal Article
Reynolds, D. M. (2003). Rapid and direct determination of tryptophan in water using synchronous fluorescence spectroscopy. Water Research, 37(13), 3055-3060. https://doi.org/10.1016/S0043-1354%2803%2900153-2

Water samples from lakes situated in and around the area of Tsukuba Science City, Ibaraki Prefecture, Japan, were analysed using synchronous fluorescence spectroscopy and HPLC. The spectra revealed a major emission peak (λemm) at 340nm corresponding... Read More about Rapid and direct determination of tryptophan in water using synchronous fluorescence spectroscopy.

Bile metabolites of polycyclic aromatic hydrocarbons (PAHs) in European eels Anguilla anguilla from United Kingdom estuaries (2003)
Journal Article
Ruddock, P. J., Bird, D. J., McEvoy, J., & Peters, L. D. (2003). Bile metabolites of polycyclic aromatic hydrocarbons (PAHs) in European eels Anguilla anguilla from United Kingdom estuaries. Science of the Total Environment, 301(1-3), 105-117. https://doi.org/10.1016/S0048-9697%2802%2900292-9

A total of 94 European eels (Anguilla anguilla) were collected from five estuaries in the UK. The deconjugated metabolites of polycyclic aromatic hydrocarbons (PAHs) in the bile of the eels were separated using HPLC. Six PAH metabolites were identifi... Read More about Bile metabolites of polycyclic aromatic hydrocarbons (PAHs) in European eels Anguilla anguilla from United Kingdom estuaries.

Sensors/biosensors, based on screen-printing technology for biomedical applications (2003)
Journal Article
Ryan, S. L., Hart, J. P., Abass, A., Honeychurch, K. C., Pemberton, R., & Wedge, R. (2003). Sensors/biosensors, based on screen-printing technology for biomedical applications. Indian Journal of Chemistry.section A.inorganic, Physical, Theoretical && Analytical, 42A(4), 709-718

This article describes three recent developments from our laboratory, in which screen-printed carbon electrodes have been modified in order to develop sensors/biosensors for analytes of biomedical importance. The analytical applications described are... Read More about Sensors/biosensors, based on screen-printing technology for biomedical applications.