Preliminary evidence of anxiolytic effects of the CRF1 receptor antagonist R317573 in the 7.5% CO2 proof-of-concept experimental model of human anxiety
(2011)
Journal Article
Bailey, J. E., Papadopoulos, A., Diaper, A., Phillips, S., Schmidt, M. E., Van Der Ark, P., …Nutt, D. J. (2011). Preliminary evidence of anxiolytic effects of the CRF1 receptor antagonist R317573 in the 7.5% CO2 proof-of-concept experimental model of human anxiety. Journal of Psychopharmacology, 25(9), 1199-1206. https://doi.org/10.1177/0269881111400650
We have validated the use of prolonged inhalation of 7.5% carbon dioxide (CO2) as a human model of anxiety and have shown that drugs from two prototypical classes of anxiolytics, benzodiazepines and a serotonin reuptake inhibitor, attenuate CO2-induc... Read More about Preliminary evidence of anxiolytic effects of the CRF1 receptor antagonist R317573 in the 7.5% CO2 proof-of-concept experimental model of human anxiety.