All Outputs (89)

Characterisation of three bacteriophages infecting serovars of salmonella enterica (2013)
Thesis
Turner, D. Characterisation of three bacteriophages infecting serovars of salmonella enterica. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/940605

A collection of three newly isolated Salmonella bacteriophages, vB_SenS-Ent1, vB_SenS-Ent2 and vB_SenS-Ent3 was established. These bacteriophages were characterised by electron microscopy, host range, sensitivity to restriction enzymes and profiles o... Read More about Characterisation of three bacteriophages infecting serovars of salmonella enterica.

Open science and public engagement: Exploring the potential of the open paradigm to support public engagement with science (2012)
Thesis
Grand, A. (in press). Open science and public engagement: Exploring the potential of the open paradigm to support public engagement with science. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/941959

Open science, a practice in which the entirety of a research project is made available, via the Internet, using a variety of tools and techniques, is an emerging approach to the conduct of science. The hypothesis that open science therefore has the p... Read More about Open science and public engagement: Exploring the potential of the open paradigm to support public engagement with science.

Use of lux gene technology to investigate real-time in-situ interactions of bacterial pathogens with a model blood-brain barrier system (2012)
Thesis
Grimshaw, K. L. Use of lux gene technology to investigate real-time in-situ interactions of bacterial pathogens with a model blood-brain barrier system. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/946792

Bacterial bioluminescence has been shown to be an accurate real-time reporter of bacterial internalisation and a valid alternative to viable counts. A self-bioluminescent strain of the bacterial pathogen Neisseria meningitidis was used to develop and... Read More about Use of lux gene technology to investigate real-time in-situ interactions of bacterial pathogens with a model blood-brain barrier system.

Molecular genetics and functional characterization of ciliopathies (2011)
Thesis
Wheway, G. Molecular genetics and functional characterization of ciliopathies. (Thesis). University of Leeds. Retrieved from https://uwe-repository.worktribe.com/output/972312

Primary cilia are microtubule-based organelles projecting from most epithelial cells in vertebrates, with numerous essential roles in chemo- and mechanosensation. A suite of inherited human conditions are caused by defects in the structure or functio... Read More about Molecular genetics and functional characterization of ciliopathies.

The potential role of the hedgehog signalling pathway in the regulation of epithelial-mesenchymal transition in breast cancer
Thesis
Flemban, A. (2019). The potential role of the hedgehog signalling pathway in the regulation of epithelial-mesenchymal transition in breast cancer. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/849034

Breast cancer is a deadly disease that accounts for a third of all female cancer- related deaths globally. Although recent advances in early diagnosis and targeted therapy using prognostic markers have reduced deaths, more than 50% of newly diagnosed... Read More about The potential role of the hedgehog signalling pathway in the regulation of epithelial-mesenchymal transition in breast cancer.

Glycoprotein estimation and analysis of genes associated with inherited platelet disorders and complications of pregnancy
Thesis
Poles, A. (2013). Glycoprotein estimation and analysis of genes associated with inherited platelet disorders and complications of pregnancy. (Thesis). NHSBT. Retrieved from https://uwe-repository.worktribe.com/output/936250

Abstract The archetypical inherited platelet (PLT) disorders are Glanzmann’s Thrombasthenia (GT) and Bernard Soulier Syndrome (BSS) and both are autosomal recessive disorders. GT results from mutations in the ITGB3 and/or ITGA2B genes that encode t... Read More about Glycoprotein estimation and analysis of genes associated with inherited platelet disorders and complications of pregnancy.

The role of developmental/relational trauma in therapists' motivation to pursue a psychotherapeutic career: A grounded theory exploration
Thesis
Davies, J. M. M. (2018). The role of developmental/relational trauma in therapists' motivation to pursue a psychotherapeutic career: A grounded theory exploration. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/869840

Background: Psychotherapy research has consistently established a link between developmental/relational trauma and the motivation to pursue a psychotherapeutic career. Understanding why this relationship exists is important given the recognised adv... Read More about The role of developmental/relational trauma in therapists' motivation to pursue a psychotherapeutic career: A grounded theory exploration.

The role of phosphorylation and redox regulation of the brain specific hBCAT proteins in vitro and in neuronal cells
Thesis
El Hindy, M. (2014). The role of phosphorylation and redox regulation of the brain specific hBCAT proteins in vitro and in neuronal cells. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/821153

Introduction: The hBCAT proteins have a unique redox active CXXC motif which governs its transamination activity. Recent studies have identified that specific neuronal proteins with either redox activity or functions in cell signalling form interac... Read More about The role of phosphorylation and redox regulation of the brain specific hBCAT proteins in vitro and in neuronal cells.

The modulatory effects of commensal neisseriae on upper respiratory tract infections
Thesis
Page, K. (2014). The modulatory effects of commensal neisseriae on upper respiratory tract infections. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/819796

The human nasopharynx is a reservoir of both commensal and pathogenic bacteria that can be easily transmitted from one individual to another. It has long been hypothesised that host commensal flora give protection from carriage of pathogens and invas... Read More about The modulatory effects of commensal neisseriae on upper respiratory tract infections.