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All Outputs (89)

Development of a three-dimensional in-vitro model of the human bone marrow using commercially available matrices and bone marrow derived mesenchymal stem cells/HS-5 stromal cell line (2016)
Thesis
Kabrah, S. Development of a three-dimensional in-vitro model of the human bone marrow using commercially available matrices and bone marrow derived mesenchymal stem cells/HS-5 stromal cell line. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/10596716

The function of the bone marrow is known to be affected by both haematopoietic malignancies as well as the chemotherapy used to treat them. To appropriately evaluate the role of disease versus treatment, this study aimed to develop a novel three-dime... Read More about Development of a three-dimensional in-vitro model of the human bone marrow using commercially available matrices and bone marrow derived mesenchymal stem cells/HS-5 stromal cell line.

Investigations on potential digenic HAMP(hepcidin) and HFE haemochromatosis gene mutations in the development of iron overload in Irish patients with dilated cardiomyopathy (2016)
Thesis
Jereza, N. Investigations on potential digenic HAMP(hepcidin) and HFE haemochromatosis gene mutations in the development of iron overload in Irish patients with dilated cardiomyopathy. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/911991

Iron overload cardiomyopathy (IOC) has been recently described as a dilated cardiomyopathy, characterized by left ventricular (LV) remodelling with chamber dilatation and reduced LV ejection fraction (LVEF). However, primary haemochromatosis, a genet... Read More about Investigations on potential digenic HAMP(hepcidin) and HFE haemochromatosis gene mutations in the development of iron overload in Irish patients with dilated cardiomyopathy.

Development of generic methods for the analysis and purification of polar compounds by high performance liquid chromatography (2016)
Thesis
Russell, J. J. (in press). Development of generic methods for the analysis and purification of polar compounds by high performance liquid chromatography. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/914251

Generic methods were developed using different columns for analysis and purification of hydrophilic compounds by hydrophilic interaction chromatography (HILIC). Mobile phases were investigated in detail, and across each column chemistry tested (BEH A... Read More about Development of generic methods for the analysis and purification of polar compounds by high performance liquid chromatography.

The molecular epidemiology of ampC-mediated resistance in Escherichia coli: A study of clinical strains isolated from the South West region (2016)
Thesis
Lewis, J. (in press). The molecular epidemiology of ampC-mediated resistance in Escherichia coli: A study of clinical strains isolated from the South West region. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/915314

Escherichia coli is a common human pathogen, capable of causing a wide range of infections. Some strains produce AmpC beta-lactamase, an enzyme able to affect the action of antibiotics. These strains are often resistant to cephalosporin antibiotics,... Read More about The molecular epidemiology of ampC-mediated resistance in Escherichia coli: A study of clinical strains isolated from the South West region.

The development of novel fuel dehydrating icing inhibitors (2015)
Thesis
Repetto, S. L. The development of novel fuel dehydrating icing inhibitors. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/7512199

Dissolved water is a normal component of jet fuel which is vapourised during combustion; however, free water is a contaminant that can starve engines, freeze to form ice crystals capable of blocking fuel feeds, support microbial growth, and contribut... Read More about The development of novel fuel dehydrating icing inhibitors.

The design, development and application of novel, screen-printed amperometric glutamate biosensors (2015)
Thesis
Hughes, G. The design, development and application of novel, screen-printed amperometric glutamate biosensors. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/803754

The aim of the studies presented in this thesis was to develop a screen-printed electrochemical biosensor for the measurement of glutamate and to apply this device to the determination of the analyte in food, serum and toxicity studies. Chapter 1... Read More about The design, development and application of novel, screen-printed amperometric glutamate biosensors.

The expression of alternative splice variants of human epidermal growth factor receptor 2 in invasive breast cancer and cell line models (2015)
Thesis
Nkwam, E. The expression of alternative splice variants of human epidermal growth factor receptor 2 in invasive breast cancer and cell line models. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/835250

The Human Epidermal Growth Factor Receptor 2 (HER2) is an oncogene expressed in 25-30% of invasive breast cancers. The HER2 gene encodes an 185kDa transmembrane protein with tyrosine kinase activity. Gene amplification or protein expression of HER2 i... Read More about The expression of alternative splice variants of human epidermal growth factor receptor 2 in invasive breast cancer and cell line models.

Hormonal and genetic regulation of prostate cancer in Caucasian and Malaysian Chinese ethnic groups (2015)
Thesis
Kuppusamy, S. Hormonal and genetic regulation of prostate cancer in Caucasian and Malaysian Chinese ethnic groups. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/835727

Introduction Prostate Cancer (PC) is the most common cancer in men and the second biggest cause of cancer-related death of men in the Western world. There are significant ethnic differences in the incidence of PC between African Americans, Caucas... Read More about Hormonal and genetic regulation of prostate cancer in Caucasian and Malaysian Chinese ethnic groups.

The development of electrochemical biosensors for cholesterol (2015)
Thesis
Ahmadraji, T. The development of electrochemical biosensors for cholesterol. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/839336

Coronary vascular disease (CVD) is the number one cause of death worldwide. According to a WHO report and global and regional projections of mortality and burden of disease, by 2030, the number of people dying from heart disease and stroke will incre... Read More about The development of electrochemical biosensors for cholesterol.

In vitro studies comparing activities of antimicrobial photodynamic therapy and electrochemically activated solutions (2014)
Thesis
Kamil, Z. In vitro studies comparing activities of antimicrobial photodynamic therapy and electrochemically activated solutions. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/806200

Abstract There is a need for alternative “treatments” for killing microbes in wound and other body surfaces. Antimicrobial Photodynamic Therapy (APDT) and Electrochemically Activated Solutions (ECAS) are two recent developments in the field of bioci... Read More about In vitro studies comparing activities of antimicrobial photodynamic therapy and electrochemically activated solutions.

Exploring peripheral blood mononuclear cells as the source of interleukin-6 in polymyalgia rheumatica (2014)
Thesis
Bazzard, H. L. Exploring peripheral blood mononuclear cells as the source of interleukin-6 in polymyalgia rheumatica. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/806917

Polymyalgia rheumatica (PMR) is a chronic inflammatory condition which affects the elderly, causing aching and stiffness of the neck, shoulders and pelvis, as well as more systemic manifestations such as fever, malaise and fatigue. PMR shares symptom... Read More about Exploring peripheral blood mononuclear cells as the source of interleukin-6 in polymyalgia rheumatica.

The role of LPCAT in regulating cellular inflammatory responses to toll-like receptor ligands (2014)
Thesis
Hughes, J. A. The role of LPCAT in regulating cellular inflammatory responses to toll-like receptor ligands. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/817633

A novel lipid modifying enzyme, lysophosphatidylcholine acyltransferase (LPCAT), has been shown to regulate pro-inflammatory cytokine responses to lipopolysaccharide (LPS), a key molecule in initiating sepsis. Current research has shown that phosphol... Read More about The role of LPCAT in regulating cellular inflammatory responses to toll-like receptor ligands.

The use of transposon libraries to investigate the evolution of bacterial pathogenesis (2014)
Thesis
Manoharan, B. The use of transposon libraries to investigate the evolution of bacterial pathogenesis. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/819375

Pseudomonas syringae pathovar phaseolicola (Pph) is the seed borne causative agent of halo blight disease in the common bean, Phaseolus vulgaris. Gene-for-gene interactions are widespread and a very important aspect of plant disease resistance. Pph r... Read More about The use of transposon libraries to investigate the evolution of bacterial pathogenesis.

Lipotoxicity and the role of translationally controlled tumour protein (TCTP) in pancreatic β-cell survival (2014)
Thesis
Hayward, K. L. Lipotoxicity and the role of translationally controlled tumour protein (TCTP) in pancreatic β-cell survival. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/821546

Introduction: Diabetes affects more than 346 million individuals worldwide. Some 90% of diabetics have type 2 diabetes mellitus, which is frequently associated with obesity and hyperlipidemia as well as hyperglycaemia. There is ample evidence that... Read More about Lipotoxicity and the role of translationally controlled tumour protein (TCTP) in pancreatic β-cell survival.

An investigation in to the role of fatty acid binding protein-7, insulin like growth factor binding protein-2 and phosphatase and tensin homolog in triple negative breast cancer; in vitro and in vivo (2014)
Thesis
Dean, S. J. An investigation in to the role of fatty acid binding protein-7, insulin like growth factor binding protein-2 and phosphatase and tensin homolog in triple negative breast cancer; in vitro and in vivo. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/823941

Introduction Triple negative breast cancers are defined by their lack of expression of HER, oestrogen receptors and progesterone receptors. They account for around 10-24% of cases. To define a cancer by the biomarkers it does not express is unsati... Read More about An investigation in to the role of fatty acid binding protein-7, insulin like growth factor binding protein-2 and phosphatase and tensin homolog in triple negative breast cancer; in vitro and in vivo.

Exploring the implications of changing patterns of rubella immunity in antenatal women in a South Wales valley community (2013)
Thesis
Matthews, L. A. Exploring the implications of changing patterns of rubella immunity in antenatal women in a South Wales valley community. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/926313

Abstract Background/Aims: Rubella can be devastating to a foetus if maternally acquired in early pregnancy. A single rubella vaccine (SRV), given to prepubertal girls was replaced by the MMR immunisation in infancy for both sexes in 1988. Women born... Read More about Exploring the implications of changing patterns of rubella immunity in antenatal women in a South Wales valley community.

ZAP-70 Phosphorylation and other prognostic factors in adult B-chronic lymphocytic leukaemia patients (2013)
Thesis
Maramba, A. ZAP-70 Phosphorylation and other prognostic factors in adult B-chronic lymphocytic leukaemia patients. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/931681

Abstract B chronic lymphocytic leukaemia (B-CLL) is a disease with an enormously heterogeneous prognosis. Due to lack of effective treatments and the heterogeneity in its course, B-CLL has remained largely incurable. In the last two decades a number... Read More about ZAP-70 Phosphorylation and other prognostic factors in adult B-chronic lymphocytic leukaemia patients.

Identification of volatile compounds as indicators of spoilage insects and mites in grain and flour (2013)
Thesis
Abuelnnor, N. Identification of volatile compounds as indicators of spoilage insects and mites in grain and flour. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/933539

Solid-phase micro-extraction (SPME) fibres and automated thermal desorption (ATD) tubes were used with gas chromatography-mass spectrometry (GC-MS), to investigate volatile secretions from the headspace gas of adults and larvae of confused flour bee... Read More about Identification of volatile compounds as indicators of spoilage insects and mites in grain and flour.