All Outputs (89)

Processing people! The purpose and pitfalls of case management supervision provided for psychological wellbeing practitioners, working within Improving Access to Psychological Therapies (IAPT) Services: A thematic analysis (2018)
Thesis
Painter, A. Processing people! The purpose and pitfalls of case management supervision provided for psychological wellbeing practitioners, working within Improving Access to Psychological Therapies (IAPT) Services: A thematic analysis. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/859047

The spread of Improving Access to Psychological Therapies (IAPT) services in the National Health Service (NHS) in the UK required a new role called a Psychological Wellbeing Practitioner (PWP). The PWP role was envisioned as a frontline position requ... Read More about Processing people! The purpose and pitfalls of case management supervision provided for psychological wellbeing practitioners, working within Improving Access to Psychological Therapies (IAPT) Services: A thematic analysis.

An investigation into the function and regulation Of ERG Exon 7b (2018)
Thesis
Jumbe, S. An investigation into the function and regulation Of ERG Exon 7b. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/1494104

The ETS family transcription factor ERG is a key oncoprotein in bone, blood, vascular and most notably prostate cancer where it is activated in at least 50% of cases. Of the several splice isoforms of ERG with variable biological activity those that... Read More about An investigation into the function and regulation Of ERG Exon 7b.

Bacterial processing of fluorescent organic matter in freshwater (2018)
Thesis
Fox, B. Bacterial processing of fluorescent organic matter in freshwater. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/863820

Organic matter (OM) is ubiquitous to all aquatic environments and plays an essential role in global biogeochemical cycles and transportation of organic carbon throughout the hydrological continuum. Excitation-emission matrix (EEM) fluorescence spectr... Read More about Bacterial processing of fluorescent organic matter in freshwater.

The isolation and characterisation of Proteus mirabilis bacteriophages and their effect on the colonisation and blockage of urinary catheters (2018)
Thesis
Thompson, R. The isolation and characterisation of Proteus mirabilis bacteriophages and their effect on the colonisation and blockage of urinary catheters. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/866010

Catheter associated urinary tract infection seriously complicates the care of an already vulnerable patient set and has been estimated to cost the UK National Health Service in excess of one billion pounds per annum. Approximately 50 % of patients ca... Read More about The isolation and characterisation of Proteus mirabilis bacteriophages and their effect on the colonisation and blockage of urinary catheters.

Biodiversity and ecosystem function in the bird's nest fern (2018)
Thesis
Donald, J. D. Biodiversity and ecosystem function in the bird's nest fern. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/866762

Understanding the relationship between the biodiversity and functioning of an ecosystem is a key component of ecological studies. Given the importance of soil as the basis for life on earth, understanding this relationship across the multiple trophic... Read More about Biodiversity and ecosystem function in the bird's nest fern.

The development of molecular assays for the detection and identification of inherited disorders of haemoglobin in a highly heterogeneous population (2018)
Thesis
Turner, A. The development of molecular assays for the detection and identification of inherited disorders of haemoglobin in a highly heterogeneous population. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/876211

Inherited disorders of haemoglobin are the most common monogenic diseases in the world. These conditions arise as a result of deletions or point mutations affecting the globin genes. Gap polymerase chain reaction (Gap-PCR) is commonly used to detect... Read More about The development of molecular assays for the detection and identification of inherited disorders of haemoglobin in a highly heterogeneous population.

Interaction of nitric oxide with auxin and ethylene signalling in Arabidopsis root gravitropism (2017)
Thesis
Vembu, K. Interaction of nitric oxide with auxin and ethylene signalling in Arabidopsis root gravitropism. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/877297

Gravitropism is required for the appropriate alignment of the plant root and shoot. According to the Cholodny-Went hypothesis, gravity induces asymmetric accumulation of auxin in the lower side of the root tissue. More recent studies on root gravitro... Read More about Interaction of nitric oxide with auxin and ethylene signalling in Arabidopsis root gravitropism.

Quantum pathogen evolution by integron-mediated effector capture (2017)
Thesis
Payne, J. D. Quantum pathogen evolution by integron-mediated effector capture. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/877432

Plant pathogenic Pseudomonads are responsible for the loss of millions of pounds in crop revenue each year. They export effector molecules via the type three secretion system into the plants’ cells in order to elicit disease. If the plant has the cor... Read More about Quantum pathogen evolution by integron-mediated effector capture.

Factors affecting engagement with informal science learning in Thailand: A regional perspective (2017)
Thesis
Triyarat, W. Factors affecting engagement with informal science learning in Thailand: A regional perspective. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/877445

Abstract There is currently minimal understanding as to how informal science learning affects young people’s scientific performance, attitudes and experiences at a regional level in Thailand. This thesis is the first to investigate this topic by... Read More about Factors affecting engagement with informal science learning in Thailand: A regional perspective.

Targeting splice factor kinases and their splice factor in chronic myeloid leukaemia (2017)
Thesis
Alabouh, H. Targeting splice factor kinases and their splice factor in chronic myeloid leukaemia. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/879470

Alternative splicing of pre-mRNA is a ubiquitous and versatile mechanism controlling the expression of human genes. In humans, approximately 93% of multi-exonic genes are alternatively spliced, producing functionally distinct proteins. Dysregulation... Read More about Targeting splice factor kinases and their splice factor in chronic myeloid leukaemia.

The effect of hypoxia on alternative splicing in prostate cancer cell lines (2017)
Thesis
Bowler, E. The effect of hypoxia on alternative splicing in prostate cancer cell lines. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/879763

Hypoxia is defined as the state in which the availability or delivery of oxygen is insufficient to meet tissue demand. It occurs particularly in aggressive, fast-growing tumours in which the rate of new blood vessel formation (angiogenesis) cannot ma... Read More about The effect of hypoxia on alternative splicing in prostate cancer cell lines.

Body image in midlife: Developing a psychosocial intervention for women who have received treatment for breast cancer (2017)
Thesis
Lewis-Smith, H. Body image in midlife: Developing a psychosocial intervention for women who have received treatment for breast cancer. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/886181

Survival rates for breast cancer have improved over the recent decades, and increasing numbers of women in midlife are coming to terms with the consequences of the disease and its treatment. Among the various side-effects associated with treatment ar... Read More about Body image in midlife: Developing a psychosocial intervention for women who have received treatment for breast cancer.

Genotoxicity and functionality assessment of a bone marrow stromal cell line following chemotherapy exposure in an in vitro model of multiple myeloma (2017)
Thesis
Andrews, S. W. Genotoxicity and functionality assessment of a bone marrow stromal cell line following chemotherapy exposure in an in vitro model of multiple myeloma. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/887562

Multiple myeloma (MM) is a haematological malignancy characterized by terminally differentiated plasma cells and their accumulation in the bone marrow (BM). Despite significant advances in therapeutic strategies it currently remains incurable. The in... Read More about Genotoxicity and functionality assessment of a bone marrow stromal cell line following chemotherapy exposure in an in vitro model of multiple myeloma.

Redox binding partners of the hBCAT proteins and their distribution and expression in control and disease human brains: Implications in protein folding in neurodegeneration (2017)
Thesis
Lee, C. Redox binding partners of the hBCAT proteins and their distribution and expression in control and disease human brains: Implications in protein folding in neurodegeneration. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/888429

INTRODUCTION: Novel binding partners of the branched chain aminotransferase proteins (hBCAT) proteins have been identified and indicate that these metabolic proteins may have alternative functions to their housekeeping role. In particular, the molecu... Read More about Redox binding partners of the hBCAT proteins and their distribution and expression in control and disease human brains: Implications in protein folding in neurodegeneration.

The role of dysregulated autophagy in Alzheimer's disease (2017)
Thesis
Harris, M. N. The role of dysregulated autophagy in Alzheimer's disease. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/897691

Introduction: The accumulation of misfolded Aβ and phospho-tau are characteristic features of Alzheimer’s disease (AD) pathology. One of the cellular mechanisms responsible for the removal of these aggregates is autophagy, where proteins and organel... Read More about The role of dysregulated autophagy in Alzheimer's disease.

The impact of Joint Hypermobility Syndrome in adults: A quantitative exploration of neuromuscular impairments, activity limitations and participation restrictions (2017)
Thesis
Alsiri, N. The impact of Joint Hypermobility Syndrome in adults: A quantitative exploration of neuromuscular impairments, activity limitations and participation restrictions. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/897612

Abstract: Introduction: Joint hypermobility syndrome (JHS) is a heritable connective tissue disorder associated with multiple joint laxity and pain. JHS is severe and disabling condition with a prevalence reaching 55% of patients attended physiother... Read More about The impact of Joint Hypermobility Syndrome in adults: A quantitative exploration of neuromuscular impairments, activity limitations and participation restrictions.

Therapists’ and non-therapists’ constructions of heterosex: A story completion study (2017)
Thesis
A story completion study. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/899220

This thesis explores the discourses underpinning therapists’ and non-therapists’ constructions of sexual experimentation and masturbation in heterosexual relationships. A constructionist thematic analysis of 200 story completions written by 58 therap... Read More about Therapists’ and non-therapists’ constructions of heterosex: A story completion study.

The role of beta-cell glutamate receptors in pancreatic endocrine function and in the pathogenesis of type 1 diabetes mellitus (2017)
Thesis
Dwomoh, L. The role of beta-cell glutamate receptors in pancreatic endocrine function and in the pathogenesis of type 1 diabetes mellitus. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/900722

Background: Kainate receptors (KARs) are one of the three classes of ionotropic glutamate receptors (iGluRs) expressed primarily in the central nervous system (CNS) where they mediate information transfer and neurotransmitter release. Very little is... Read More about The role of beta-cell glutamate receptors in pancreatic endocrine function and in the pathogenesis of type 1 diabetes mellitus.

New Labour in power in the English countryside 1997 - 2010: A social democratic moment forgone? (2017)
Thesis
Drew, D. New Labour in power in the English countryside 1997 - 2010: A social democratic moment forgone?. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/900716

An unprecedented number of Labour MPs was elected in rural areas in England in 1997. This study examines critically examines the making of rural policy and the implications for rural politics over the life-time of New Labour in power between 1997 and... Read More about New Labour in power in the English countryside 1997 - 2010: A social democratic moment forgone?.

The development of a point of care device for measuring blood ammonia (2017)
Thesis
Brannelly, N. The development of a point of care device for measuring blood ammonia. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/900674

Ammonia is produced in the body during the metabolism of amino acids. In the liver, it is converted to urea via the urea cycle and excreted by the kidneys as urine. Normal levels are between 11 to 50 µM, whereas a blood ammonia level of approximately... Read More about The development of a point of care device for measuring blood ammonia.