All Outputs (32)

Differentiation of SH-SY5Y neuroblastoma cells using retinoic acid and BDNF: A model for neuronal and synaptic differentiation in neurodegeneration (2024)
Journal Article

There has been much interest in the use of cell culture models of neurones, to avoid the animal welfare and cost issues of using primary and human-induced pluripotent stem cell (hiPSC)-derived neurones respectively. The human neuroblastoma cell line,... Read More about Differentiation of SH-SY5Y neuroblastoma cells using retinoic acid and BDNF: A model for neuronal and synaptic differentiation in neurodegeneration.

SGIP1 binding to the α-helical H9 domain of cannabinoid receptor 1 promotes axonal surface expression (2024)
Journal Article

Endocannabinoid signalling mediated by cannabinoid receptor 1 (CB1R, also known as CNR1) is critical for homeostatic neuromodulation of both excitatory and inhibitory synapses. This requires highly polarised axonal surface expression of CB1R, but how... Read More about SGIP1 binding to the α-helical H9 domain of cannabinoid receptor 1 promotes axonal surface expression.

Animal Welfare in a Pandemic: What Does COVID-19 Tell us for the Future? (2024)
Book

Animal Welfare in a Pandemic explores the impact of COVID-19 on a wide array of animals, from those in the wild to companion and captive animals. During the height of the pandemic, a range of animals were infected, and many died, but this was hard to... Read More about Animal Welfare in a Pandemic: What Does COVID-19 Tell us for the Future?.

Understanding Hydrogen: Lessons to be learned from physical interactions between the inert gases and the globin superfamily (2022)
Journal Article

Hydrogen gas (molecular hydrogen, H2) has significant effects in a range of organisms, from plants to humans. Many inert gases have been reported to have similar effects, and such responses may be most pronounced when cells are stressed. Xenon (Xe),... Read More about Understanding Hydrogen: Lessons to be learned from physical interactions between the inert gases and the globin superfamily.

The indirect impact of COVID-19 on the life of animals (2022)
Digital Artefact

The COVID-19 pandemic is an ongoing major health crisis that is the result of the SARS-CoV-2 virus. The virus was first identified in Wuhan, China during December 2019; many patients were initially reported with pneumonia and later the cause was foun... Read More about The indirect impact of COVID-19 on the life of animals.

Do SNPs in glutathione S-transferase-omega allow predictions of the susceptibility of vertebrates to SARS-CoV-2? (2022)
Journal Article

Infection with the SARS-Cov-2 virus causes COVID-19 in humans, and is the cause of the pandemic around the world in 2020 and on. However, some animals have been found to be susceptible to the virus too. This has included the non-human primates, dogs,... Read More about Do SNPs in glutathione S-transferase-omega allow predictions of the susceptibility of vertebrates to SARS-CoV-2?.

WT1 activates transcription of the splice factor kinase SRPK1 gene in PC3 and K562 cancer cells in the absence of corepressor BASP1 (2020)
Journal Article

Dysregulated alternative splicing plays a prominent role in all hallmarks of cancer. The splice factor kinase SRPK1 drives the activity of oncogenic splice factors such as SRSF1. SRSF1 in turn promotes the expression of splice isoforms that favour tu... Read More about WT1 activates transcription of the splice factor kinase SRPK1 gene in PC3 and K562 cancer cells in the absence of corepressor BASP1.

Phosphorylation of Syntaxin‐1a by casein kinase 2α (CK2α) regulates presynaptic vesicle exocytosis from the reserve pool (2020)
Journal Article

The t-soluble NSF-attachment protein receptor protein Syntaxin-1a (Stx-1a) is abundantly expressed at pre-synaptic terminals where it plays a critical role in the exocytosis of neurotransmitter-containing synaptic vesicles. Stx-1a is phosphorylated... Read More about Phosphorylation of Syntaxin‐1a by casein kinase 2α (CK2α) regulates presynaptic vesicle exocytosis from the reserve pool.

Polydopamine-lysophosphatidate-functionalised titanium: A novel hybrid surface finish for bone regenerative applications (2020)
Journal Article

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Aseptic loo... Read More about Polydopamine-lysophosphatidate-functionalised titanium: A novel hybrid surface finish for bone regenerative applications.

Insulin-dependent GLUT4 trafficking is not regulated by protein SUMOylation in L6 myocytes (2019)
Journal Article

Type-II Diabetes Mellitus (T2DM) is one of the fastest growing public health issues today, consuming 12% of worldwide health budgets and affecting an estimated 400 million people. One of the key pathological traits of this disease is insulin resistan... Read More about Insulin-dependent GLUT4 trafficking is not regulated by protein SUMOylation in L6 myocytes.

Protein SUMOylation regulates insulin secretion at multiple stages (2019)
Journal Article

Type-II Diabetes Mellitus (T2DM) is one of the fastest growing public health issues of modern times, consuming 12% of worldwide health budgets and affecting an estimated 400 million people. A key pathological trait associated with this disease is the... Read More about Protein SUMOylation regulates insulin secretion at multiple stages.

MEF2A regulates mGluR-dependent AMPA receptor trafficking independently of Arc/Arg3.1 (2018)
Journal Article

© 2018 The Author(s). Differential trafficking of AMPA receptors (AMPARs) to and from the postsynaptic membrane is a key determinant of the strength of excitatory neurotransmission, and is thought to underlie learning and memory. The transcription fa... Read More about MEF2A regulates mGluR-dependent AMPA receptor trafficking independently of Arc/Arg3.1.

Commentary: Analysis of SUMO1-conjugation at synapses (2017)
Journal Article

Competition of reactive signals and thiol modifications of proteins (2017)
Journal Article

It is clear that cells are constantly bombarded by multiple signals, often initiating similar, or even conflicting, responses. Important players in this suite of signals are the reactive oxygen species (ROS), such as hydrogen peroxide (H2O2), the rea... Read More about Competition of reactive signals and thiol modifications of proteins.

SUMOylation of Syntaxin1A regulates presynaptic endocytosis (2015)
Journal Article

Neurotransmitter release from the presynaptic terminal is under very precise spatial and temporal control. Following neurotransmitter release, synaptic vesicles are recycled by endocytosis and refilled with neurotransmitter. During the exocytosis eve... Read More about SUMOylation of Syntaxin1A regulates presynaptic endocytosis.

SUMOylation of synapsin Ia maintains synaptic vesicle availability and is reduced in an autism mutation (2015)
Journal Article

© 2015 Macmillan Publishers Limited. All rights reserved. Synapsins are key components of the presynaptic neurotransmitter release machinery. Their main role is to cluster synaptic vesicles (SVs) to each other and anchor them to the actin cytoskeleto... Read More about SUMOylation of synapsin Ia maintains synaptic vesicle availability and is reduced in an autism mutation.

Fighting polyglutamine disease by wrestling with SUMO (2015)
Journal Article

Spinobulbar muscular atrophy (SBMA) is an X-linked disease characterized by degeneration of motor neurons, muscle atrophy, and progressive weakness. It is caused by a polyglutamine (polyQ) expansion in the androgen receptor (AR), a transcription fact... Read More about Fighting polyglutamine disease by wrestling with SUMO.

Neuronal SUMOylation: Mechanisms, Physiology, and Roles in Neuronal Dysfunction (2014)
Journal Article

Protein SUMOylation is a critically important posttranslational protein modification that participates in nearly all aspects of cellular physiology. In the nearly 20 years since its discovery, SUMOylation has emerged as a major regulator of nuclear f... Read More about Neuronal SUMOylation: Mechanisms, Physiology, and Roles in Neuronal Dysfunction.

RIM1α SUMOylation is required for fast synaptic vesicle exocytosis (2013)
Journal Article

The rapid, activity-dependent quantal presynaptic release of neurotransmitter is vital for brain function. The complex process of vesicle priming, fusion, and retrieval is very precisely controlled and requires thespatiotemporal coordination of multi... Read More about RIM1α SUMOylation is required for fast synaptic vesicle exocytosis.

SUMOylation is required for glycine-induced increases in AMPA receptor surface expression (ChemLTP) in hippocampal neurons (2013)
Journal Article

Multiple pathways participate in the AMPA receptor trafficking that underlies long-term potentiation (LTP) of synaptic transmission. Here we demonstrate that protein SUMOylation is required for insertion of the GluA1 AMPAR subunit following transient... Read More about SUMOylation is required for glycine-induced increases in AMPA receptor surface expression (ChemLTP) in hippocampal neurons.