All Outputs (3)

Cytochrome c release from isolated rat liver mitochondria can occur independently of outer-membrane rupture: possible role of contact sites (2000)
Journal Article
Doran (nee Udovikova), O., & Halestrap, A. (2000). Cytochrome c release from isolated rat liver mitochondria can occur independently of outer-membrane rupture: possible role of contact sites. Biochemical Journal, 348(2), 343-350

Percoll-purified rat liver mitochondria were shown to contain BAX dimer and rapidly (

Mitochondria and cell death: a pore way to die? (2000)
Journal Article
Halestrap, A., Gillespie, J., O'Toole, A., & Doran (nee Udovikova), O. (2000). Mitochondria and cell death: a pore way to die?. Symposia- Society for Experimental Biology, 52, 65-80

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain (2000)
Journal Article
Owen, M., Doran (nee Udovikova), O., & Halestrap, A. (2000). Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochemical Journal, 348(3), 607-614

Although metformin is widely used for the treatment of non-insulin-dependent diabetes, its mode of action remains unclear. Here we provide evidence that its primary site of action is through a direct inhibition of complex 1 of the respiratory chain.... Read More about Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain.