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New insights into the role of the branched-chain aminotransferase proteins in the human brain (2015)
Journal Article
Hull, J., Patel, V. B., Hutson, S. M., & Conway, M. E. (2015). New insights into the role of the branched-chain aminotransferase proteins in the human brain. Journal of Neuroscience Research, 93(7), 987-998. https://doi.org/10.1002/jnr.23558

The human cytosolic branched-chain aminotransferase (hBCATc) enzyme is strategically located in glutamatergic neurons, where it is thought to provide approximately 30% of de novo nitrogen for brain glutamate synthesis. In health, glutamate plays a do... Read More about New insights into the role of the branched-chain aminotransferase proteins in the human brain.

Regional increase in the expression of the BCAT proteins in Alzheimer's disease brain: Implications in glutamate toxicity (2015)
Journal Article
Hull, J., Patel, V., El Hindy, M., Lee, C., Odeleye, E., Hezwani, M., …Conway, M. E. (2015). Regional increase in the expression of the BCAT proteins in Alzheimer's disease brain: Implications in glutamate toxicity. Journal of Alzheimer's Disease, 45(3), 891-905. https://doi.org/10.3233/JAD-142970

BACKGROUND The human branched chain aminotransferases (hBCATm, mitochondrial and hBCATc, cytosolic) are major contributors to brain glutamate production. This excitatory neurotransmitter is thought to contribute to neurotoxicity in neurodegenerati... Read More about Regional increase in the expression of the BCAT proteins in Alzheimer's disease brain: Implications in glutamate toxicity.