All Outputs (3)

Ternary nanocomposite potentiates the lysophosphatidic acid effect on human osteoblast (MG63) maturation (2023)
Journal Article
Elkhenany, H., Elkodous, M. A., & Mansell, J. (2023). Ternary nanocomposite potentiates the lysophosphatidic acid effect on human osteoblast (MG63) maturation. Nanomedicine, 18(21), 1459-1475. https://doi.org/10.2217/nnm-2023-0117

Aim: This study aimed to investigate the potential of ternary nanocomposite (TNC) to support MG63 osteoblast maturation to EB1089-(3S)1-fluoro-3-hydroxy-4-(oleoyloxy)butyl-1-phosphonate (FHBP) cotreatment. Materials & methods: Binary (P25/reduced gra... Read More about Ternary nanocomposite potentiates the lysophosphatidic acid effect on human osteoblast (MG63) maturation.

An N-cyanoamide derivative of lithocholic acid co-operates with lysophosphatidic acid to promote human osteoblast (MG63) differentiation (2023)
Journal Article
Mansell, J. P., Tanatani, A., & Kagechika, H. (2023). An N-cyanoamide derivative of lithocholic acid co-operates with lysophosphatidic acid to promote human osteoblast (MG63) differentiation. Biomolecules, 13(7), Article 1113. https://doi.org/10.3390/biom13071113

Less-calcaemic vitamin D receptor (VDR) agonists have the potential to promote osteoblast maturation in a bone regenerative setting. The emergence of lithocholic acid (LCA) as a bona fide VDR agonist holds promise as an adjunct for arthroplasty follo... Read More about An N-cyanoamide derivative of lithocholic acid co-operates with lysophosphatidic acid to promote human osteoblast (MG63) differentiation.

Development of an antimicrobial lipid coating to prevent infections in uncemented joint replacements (2023)
Journal Article
Azizova, L., Morgan, D., Rowlands, J., Brousseau, E., Kulik, T., Palianytsia, B., …Ayre, W. (2023). Development of an antimicrobial lipid coating to prevent infections in uncemented joint replacements. Orthopaedic Proceedings, 105-B(SUPP_9), 80-80. https://doi.org/10.1302/1358-992x.2023.9.080

Preventing infections in joint replacements is a major ongoing challenge, with limited effective clinical technologies currently available for uncemented knee and hip prostheses. This research aims to develop a coating for titanium implants, consisti... Read More about Development of an antimicrobial lipid coating to prevent infections in uncemented joint replacements.