A high-throughput genome-wide siRNA screen for ciliogenesis identifies new ciliary functional components and ciliopathy genes
(2015)
Journal Article
Nguyen, T. M., Wheway, G., Szymanska, K., Wheway, G., Doherty, D., Schmidts, M., …Johnson, C. (2015). A high-throughput genome-wide siRNA screen for ciliogenesis identifies new ciliary functional components and ciliopathy genes. Cilia, 4(SUPPLEMENT 1), O12. https://doi.org/10.1186/2046-2530-4-S1-O12
Defects in primary cilium biogenesis underlie the ciliopathies, a growing group of genetic disorders. We describe the first whole genome siRNA-based reverse genetics screen for defects in biogenesis and/or maintenance of the primary cilium, obtaining... Read More about A high-throughput genome-wide siRNA screen for ciliogenesis identifies new ciliary functional components and ciliopathy genes.