All Outputs (9)

MicroRNAs, damage levels, and DNA damage response control (2021)
Journal Article
Visser, H., & Thomas, A. D. (2021). MicroRNAs, damage levels, and DNA damage response control. Trends in Genetics, 37(11), 963-965. https://doi.org/10.1016/j.tig.2021.06.018

DNA damage–inducible miRNAs are likely to be functional in the DNA damage response. This response can elicit damage resolution and cell survival or apoptosis. The current, albeit incomplete, picture suggests that miRNAs can affect cell fate via modul... Read More about MicroRNAs, damage levels, and DNA damage response control.

Estragole: DNA adduct formation in primary rat hepatocytes and genotoxic potential in HepG2-CYP1A2 cells (2020)
Journal Article
Schulte-Hubbert, R., Küpper, J. H., Thomas, A. D., & Schrenk, D. (2020). Estragole: DNA adduct formation in primary rat hepatocytes and genotoxic potential in HepG2-CYP1A2 cells. Toxicology, 444, Article 152566. https://doi.org/10.1016/j.tox.2020.152566

Estragole is a natural constituent in herbs and spices and in products thereof such as essential oils or herbal teas. After cytochrome P450-catalyzed hydroxylation and subsequent sulfation, estragole acts as a genotoxic hepatocarcinogen forming DNA a... Read More about Estragole: DNA adduct formation in primary rat hepatocytes and genotoxic potential in HepG2-CYP1A2 cells.

Immunological and mass spectrometry-based approaches to determine thresholds of the mutagenic DNA adduct O 6 -methylguanine in vivo (2018)
Journal Article
Kraus, A., McKeague, M., Seiwert, N., Nagel, G., Geisen, S. M., Ziegler, N., …Fahrer, J. (2019). Immunological and mass spectrometry-based approaches to determine thresholds of the mutagenic DNA adduct O 6 -methylguanine in vivo. Archives of Toxicology, 93(2), 559-572. https://doi.org/10.1007/s00204-018-2355-0

© 2018, Springer-Verlag GmbH Germany, part of Springer Nature. N-nitroso compounds are alkylating agents, which are widespread in our diet and the environment. They induce DNA alkylation adducts such as O 6 -methylguanine (O 6 -MeG), which is repair... Read More about Immunological and mass spectrometry-based approaches to determine thresholds of the mutagenic DNA adduct O 6 -methylguanine in vivo.

Genetic toxicity assessment of engineered nanoparticles using a 3D in vitro skin model (EpiDerm ™ ) (2016)
Journal Article
Wills, J. W., Hondow, N., Thomas, A. D., Chapman, K. E., Fish, D., Maffeis, T. G., …Doak, S. H. (2016). Genetic toxicity assessment of engineered nanoparticles using a 3D in vitro skin model (EpiDerm ™ ). Particle and Fibre Toxicology, 13, Article 50. https://doi.org/10.1186/s12989-016-0161-5

© 2016 The Author(s). Background: The rapid production and incorporation of engineered nanomaterials into consumer products alongside research suggesting nanomaterials can cause cell death and DNA damage (genotoxicity) makes in vitro assays desirabl... Read More about Genetic toxicity assessment of engineered nanoparticles using a 3D in vitro skin model (EpiDerm ™ ).

DNA repair by MGMT, but not AAG, causes a threshold in alkylation-induced colorectal carcinogenesis (2015)
Journal Article
Fahrer, J., Frisch, J., Nagel, G., Kraus, A., Dörsam, B., Thomas, A. D., …Kaina, B. (2015). DNA repair by MGMT, but not AAG, causes a threshold in alkylation-induced colorectal carcinogenesis. Carcinogenesis, 36(10), 1235-1244. https://doi.org/10.1093/carcin/bgv114

© The Author 2015. Published by Oxford University Press. All rights reserved. Epidemiological studies indicate that N-nitroso compounds (NOC) are causally linked to colorectal cancer (CRC). NOC induce DNA alkylations, including O6-methylguanine (O6-M... Read More about DNA repair by MGMT, but not AAG, causes a threshold in alkylation-induced colorectal carcinogenesis.

Automation and validation of micronucleus detection in the 3D EpiDerm™ human reconstructed skin assay and correl (2014)
Journal Article
Chapman, K., Thomas, A. D., Wills, J., Pfuhler, S., Doak, S. H., & Jenkins, G. J. (2014). Automation and validation of micronucleus detection in the 3D EpiDerm™ human reconstructed skin assay and correl. Mutagenesis, 29(3), 165-175. https://doi.org/10.1093/mutage/geu011

Recent restrictions on the testing of cosmetic ingredients in animals have resulted in the need to test the genotoxic potential of chemicals exclusively in vitro prior to licensing. However, as current in vitro tests produce some misleading positive... Read More about Automation and validation of micronucleus detection in the 3D EpiDerm™ human reconstructed skin assay and correl.

Does increase in DNA repair allow "Tolerance-to-Insult" in chemical carcinogenesis? Skin tumor experiments with MGMT-overexpressing mice (2013)
Journal Article
Becker, K., Thomas, A. D., & Kaina, B. (2014). Does increase in DNA repair allow "Tolerance-to-Insult" in chemical carcinogenesis? Skin tumor experiments with MGMT-overexpressing mice. Environmental and Molecular Mutagenesis, 55(2), 145-150. https://doi.org/10.1002/em.21834

Several genotoxicity endpoints have been evaluated to define nonlinear dose-responses for S N 1 and S N 2 alkylating genotoxicants. Dose-response studies acknowledging the process of multistage tumorigenesis are important; however, data pertaining no... Read More about Does increase in DNA repair allow "Tolerance-to-Insult" in chemical carcinogenesis? Skin tumor experiments with MGMT-overexpressing mice.

Influence of dna repair on nonlinear dose-responses for mutation (2013)
Journal Article
Johnson, G. E., Doak, S. H., Lewis, P. D., Bodger, O. G., Thomas, A. D., Jenkins, G. J., …Johnson, G. (2013). Influence of dna repair on nonlinear dose-responses for mutation. Toxicological Sciences, 132(1), 87-95. https://doi.org/10.1093/toxsci/kfs341

Recent evidence has challenged the default assumption that all DNA-reactive alkylating agents exhibit a linear dose-response. Emerging evidence suggests that the model alkylating agents methyl- and ethylmethanesulfonate and methylnitrosourea (MNU) an... Read More about Influence of dna repair on nonlinear dose-responses for mutation.

Vinblastine and diethylstilboestrol tested in the in vitro mammalian cell micronucleus test (MNvit) at Swansea University UK in support of OECD draft Test Guideline 487 (2010)
Journal Article
Doak, S. H., Thomas, A. D., Johnson, G. E., Jenkins, G. J., & Thomas, A. D. (2010). Vinblastine and diethylstilboestrol tested in the in vitro mammalian cell micronucleus test (MNvit) at Swansea University UK in support of OECD draft Test Guideline 487. Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 702(2), 189-192. https://doi.org/10.1016/j.mrgentox.2009.07.014

The known aneugens vinblastine and diethylstilboestrol (DES) were tested in the in vitro micronucleus assay, with and without cytokinesis block in Chinese hamster CHO cells, at the laboratories of Swansea University, Swansea, UK. These experiments we... Read More about Vinblastine and diethylstilboestrol tested in the in vitro mammalian cell micronucleus test (MNvit) at Swansea University UK in support of OECD draft Test Guideline 487.