Outputs (16)

Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial (2019)
Journal Article
Crome, L., Nyirenda, M., Sajjanhar, T., Leighton, S., McLellan, S., Bell, C., …Lyttle, M. D. (2019). Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial. Lancet, 393(10186), 2125-2134. https://doi.org/10.1016/S0140-6736%2819%2930724-X

Background Phenytoin is the recommended second-line intravenous anticonvulsant for treatment of paediatric convulsive status epilepticus in the UK; however, some evidence suggests that levetiracetam could be an effective and safer alternative. This... Read More about Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial.

Enhancing practitioners’ confidence in recruitment and consent in the EcLiPSE trial: A mixed-method evaluation of site training – a Paediatric Emergency Research in the United Kingdom and Ireland (PERUKI) study (2019)
Journal Article
Woolfall, K., Roper, L., Humphreys, A., Lyttle, M. D., Messahel, S., Lee, E., …Appleton, R. (2019). Enhancing practitioners’ confidence in recruitment and consent in the EcLiPSE trial: A mixed-method evaluation of site training – a Paediatric Emergency Research in the United Kingdom and Ireland (PERUKI) study. Trials, 20, Article 181. https://doi.org/10.1186/s13063-019-3273-z

Background: EcLiPSE (Emergency treatment with Levetiracetam or Phenytoin in Status Epilepticus in children) is a randomised controlled trial (RCT) in the United Kingdom. Challenges to success include the need to immediately administer an intervention... Read More about Enhancing practitioners’ confidence in recruitment and consent in the EcLiPSE trial: A mixed-method evaluation of site training – a Paediatric Emergency Research in the United Kingdom and Ireland (PERUKI) study.

Traumatic brain injury in young children with isolated scalp haematoma (2019)
Journal Article
Bressan, S., Kochar, A., Oakley, E., Borland, M., Phillips, N., Dalton, S., …Babl, F. E. (2019). Traumatic brain injury in young children with isolated scalp haematoma. Archives of Disease in Childhood, 104(7), 664-669. https://doi.org/10.1136/archdischild-2018-316066

Objective Despite high-quality paediatric head trauma clinical prediction rules, the management of otherwise asymptomatic young children with scalp haematomas (SH) can be difficult. We determined the risk of intracranial injury when SH is the only pr... Read More about Traumatic brain injury in young children with isolated scalp haematoma.

Incidence of medically attended paediatric burns across the UK (2019)
Journal Article
Davies, K., Johnson, E. L., Hollén, L., Jones, H. M., Lyttle, M. D., Maguire, S., & Kemp, A. M. (2020). Incidence of medically attended paediatric burns across the UK. Injury Prevention, 26(1), 24-30. https://doi.org/10.1136/injuryprev-2018-042881

Objective: Childhood burns represent a burden on health services, yet the full extent of the problem is difficult to quantify. We estimated the annual UK incidence from primary care (PC), emergency attendances (EA), hospital admissions (HA) and death... Read More about Incidence of medically attended paediatric burns across the UK.

Canadian and UK/Ireland practice patterns in lumbar puncture performance in febrile neonates with bronchiolitis (2019)
Journal Article
Simone, L., Lyttle, M. D., Roland, D., Stephens, D., & Schuh, S. (2019). Canadian and UK/Ireland practice patterns in lumbar puncture performance in febrile neonates with bronchiolitis. Emergency Medicine Journal, 36(3), 148-153. https://doi.org/10.1136/emermed-2018-208000

Background Serious bacterial infections in young infants with bronchiolitis are rare. Febrile infants

Delayed presentations to emergency departments of children with head injury: A PREDICT study (2019)
Journal Article
Borland, M. L., Dalziel, S. R., Phillips, N., Lyttle, M. D., Bressan, S., Oakley, E., …Babl, F. E. (2019). Delayed presentations to emergency departments of children with head injury: A PREDICT study. Annals of Emergency Medicine, 74(1), 1-10. https://doi.org/10.1016/j.annemergmed.2018.11.035

© 2018 American College of Emergency Physicians Study objective: Existing clinical decision rules guide management for head-injured children presenting 24 hours or sooner after injury, even though some may present greater than 24 hours afterward. We... Read More about Delayed presentations to emergency departments of children with head injury: A PREDICT study.