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Outputs (89)

Development of a three-dimensional in-vitro model of the human bone marrow using commercially available matrices and bone marrow derived mesenchymal stem cells/HS-5 stromal cell line (2016)
Thesis
Kabrah, S. Development of a three-dimensional in-vitro model of the human bone marrow using commercially available matrices and bone marrow derived mesenchymal stem cells/HS-5 stromal cell line. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/10596716

The function of the bone marrow is known to be affected by both haematopoietic malignancies as well as the chemotherapy used to treat them. To appropriately evaluate the role of disease versus treatment, this study aimed to develop a novel three-dime... Read More about Development of a three-dimensional in-vitro model of the human bone marrow using commercially available matrices and bone marrow derived mesenchymal stem cells/HS-5 stromal cell line.

Investigations on potential digenic HAMP(hepcidin) and HFE haemochromatosis gene mutations in the development of iron overload in Irish patients with dilated cardiomyopathy (2016)
Thesis
Jereza, N. Investigations on potential digenic HAMP(hepcidin) and HFE haemochromatosis gene mutations in the development of iron overload in Irish patients with dilated cardiomyopathy. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/911991

Iron overload cardiomyopathy (IOC) has been recently described as a dilated cardiomyopathy, characterized by left ventricular (LV) remodelling with chamber dilatation and reduced LV ejection fraction (LVEF). However, primary haemochromatosis, a genet... Read More about Investigations on potential digenic HAMP(hepcidin) and HFE haemochromatosis gene mutations in the development of iron overload in Irish patients with dilated cardiomyopathy.

Development of generic methods for the analysis and purification of polar compounds by high performance liquid chromatography (2016)
Thesis
Russell, J. J. (in press). Development of generic methods for the analysis and purification of polar compounds by high performance liquid chromatography. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/914251

Generic methods were developed using different columns for analysis and purification of hydrophilic compounds by hydrophilic interaction chromatography (HILIC). Mobile phases were investigated in detail, and across each column chemistry tested (BEH A... Read More about Development of generic methods for the analysis and purification of polar compounds by high performance liquid chromatography.

The molecular epidemiology of ampC-mediated resistance in Escherichia coli: A study of clinical strains isolated from the South West region (2016)
Thesis
Lewis, J. (in press). The molecular epidemiology of ampC-mediated resistance in Escherichia coli: A study of clinical strains isolated from the South West region. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/915314

Escherichia coli is a common human pathogen, capable of causing a wide range of infections. Some strains produce AmpC beta-lactamase, an enzyme able to affect the action of antibiotics. These strains are often resistant to cephalosporin antibiotics,... Read More about The molecular epidemiology of ampC-mediated resistance in Escherichia coli: A study of clinical strains isolated from the South West region.

The development of novel fuel dehydrating icing inhibitors (2015)
Thesis
Repetto, S. L. The development of novel fuel dehydrating icing inhibitors. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/7512199

Dissolved water is a normal component of jet fuel which is vapourised during combustion; however, free water is a contaminant that can starve engines, freeze to form ice crystals capable of blocking fuel feeds, support microbial growth, and contribut... Read More about The development of novel fuel dehydrating icing inhibitors.

The design, development and application of novel, screen-printed amperometric glutamate biosensors (2015)
Thesis
Hughes, G. The design, development and application of novel, screen-printed amperometric glutamate biosensors. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/803754

The aim of the studies presented in this thesis was to develop a screen-printed electrochemical biosensor for the measurement of glutamate and to apply this device to the determination of the analyte in food, serum and toxicity studies. Chapter 1... Read More about The design, development and application of novel, screen-printed amperometric glutamate biosensors.

The expression of alternative splice variants of human epidermal growth factor receptor 2 in invasive breast cancer and cell line models (2015)
Thesis
Nkwam, E. The expression of alternative splice variants of human epidermal growth factor receptor 2 in invasive breast cancer and cell line models. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/835250

The Human Epidermal Growth Factor Receptor 2 (HER2) is an oncogene expressed in 25-30% of invasive breast cancers. The HER2 gene encodes an 185kDa transmembrane protein with tyrosine kinase activity. Gene amplification or protein expression of HER2 i... Read More about The expression of alternative splice variants of human epidermal growth factor receptor 2 in invasive breast cancer and cell line models.

Hormonal and genetic regulation of prostate cancer in Caucasian and Malaysian Chinese ethnic groups (2015)
Thesis
Kuppusamy, S. Hormonal and genetic regulation of prostate cancer in Caucasian and Malaysian Chinese ethnic groups. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/835727

Introduction Prostate Cancer (PC) is the most common cancer in men and the second biggest cause of cancer-related death of men in the Western world. There are significant ethnic differences in the incidence of PC between African Americans, Caucas... Read More about Hormonal and genetic regulation of prostate cancer in Caucasian and Malaysian Chinese ethnic groups.

The development of electrochemical biosensors for cholesterol (2015)
Thesis
Ahmadraji, T. The development of electrochemical biosensors for cholesterol. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/839336

Coronary vascular disease (CVD) is the number one cause of death worldwide. According to a WHO report and global and regional projections of mortality and burden of disease, by 2030, the number of people dying from heart disease and stroke will incre... Read More about The development of electrochemical biosensors for cholesterol.