Outputs (17)

Rapid in-vitro testing for chemotherapy sensitivity in leukaemia patients (2014)
Journal Article
Anderson, E., & Salisbury, V. (2014). Rapid in-vitro testing for chemotherapy sensitivity in leukaemia patients. Advances in Biochemical Engineering Biotechnology, 145, 189-214. https://doi.org/10.1007/978-3-662-43619-6_6

© Springer-Verlag Berlin Heidelberg 2014. Bioluminescent bacterial biosensors can be used in a rapid in vitro assay to predict sensitivity to commonly used chemotherapy drugs in acute myeloid leukemia (AML). The nucleoside analog cytarabine (ara-C) i... Read More about Rapid in-vitro testing for chemotherapy sensitivity in leukaemia patients.

Effects of bone marrow stromal cells on sensitivity of leukaemic cells to chemotherapy (2013)
Journal Article
Page, K., Anderson, E., Smith, A., Reid, C., Salisbury, V., Donaldson, C., & May, J. E. (2014). Effects of bone marrow stromal cells on sensitivity of leukaemic cells to chemotherapy. Mutagenesis, 29(1), 92. https://doi.org/10.1093/mutage/get060

Cytosine arabinoside (ara-C) is a key chemotherapy drug used to treat acute myeloid leukaemia (AML), however, ap- proximately 30% of patients do not respond to this therapy. 92 An evaluative assay to determine resistance/sensitivity to ara- C prior... Read More about Effects of bone marrow stromal cells on sensitivity of leukaemic cells to chemotherapy.

A novel bioluminescent bacterial biosensor for measurement of Ara-CTP and cytarabine potentiation by fludarabine in seven leukaemic cell lines (2013)
Journal Article
Conway, M., Anderson, E., Smith, M. A., Martin, A., Ruddock, M., Lamont, J., …Salisbury, V. (2013). A novel bioluminescent bacterial biosensor for measurement of Ara-CTP and cytarabine potentiation by fludarabine in seven leukaemic cell lines. Leukemia Research, 37(6), 690-696. https://doi.org/10.1016/j.leukres.2013.02.012

This study evaluates an in vitro biosensor assay capable of detecting the intracellular levels of the tri-phosphorylated form of cytarabine (Ara-CTP) within one working day. The biosensor predicted the response of seven leukaemic cell lines with vary... Read More about A novel bioluminescent bacterial biosensor for measurement of Ara-CTP and cytarabine potentiation by fludarabine in seven leukaemic cell lines.

A bioluminescent microbial biosensor for in vitro pretreatment assessment of cytarabine efficacy in leukemia (2010)
Journal Article
Salisbury, V. C., Hill, P. J., Angell, J. E., Ruddock, M. W., Martin, A. D., Alloush, H. M., …Mehta, P. (2010). A bioluminescent microbial biosensor for in vitro pretreatment assessment of cytarabine efficacy in leukemia. Clinical Chemistry, 56(12), 1862-1870. https://doi.org/10.1373/clinchem.2010.145581

BACKGROUND: The nucleoside analog cytarabine (Ara-C [cytosine arabinoside]) is the key agent for treating acute myeloid leukemia (AML); however, up to 30% of patients fail to respond to treatment. Screening of patient blood samples to determine drug... Read More about A bioluminescent microbial biosensor for in vitro pretreatment assessment of cytarabine efficacy in leukemia.

The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1 (2009)
Journal Article
Plant, K. E., Anderson, E., Simecek, N., Brown, R., Forster, S., Spinks, J., …Plant, N. (2009). The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicology and Applied Pharmacology, 235(1), 124-134. https://doi.org/10.1016/j.taap.2008.10.019

The mood stabilizing agents lithium chloride (LiCl) and sodium valproate (VPA) have recently gained interest as potential neuroprotective therapeutics. However, exploitation of these therapeutic applications is hindered by both a lack of molecular un... Read More about The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1.

The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1 (2009)
Journal Article
Plant, K., Anderson, E., Simecek, N., Brown, R., Forster, S., Spinks, J., …Plant, N. (2009). The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicology and Applied Pharmacology, 235(1), 124-134. https://doi.org/10.1016/j.taap.2008.10.019

Evaluation of HER-2/neu immunohistochemical assay sensitivity and scoring on formalin-fixed and paraffin-processed cell lines and breast tumors: A comparative study involving results from laboratories in 21 countries (2002)
Journal Article
Rhodes, A., Jasani, B., Anderson, E., Dodson, A. R., & Balaton, A. J. (2002). Evaluation of HER-2/neu immunohistochemical assay sensitivity and scoring on formalin-fixed and paraffin-processed cell lines and breast tumors: A comparative study involving results from laboratories in 21 countries. American Journal of Clinical Pathology, 118(3), 408-417. https://doi.org/10.1309/97WN-W6UX-XJWT-02H2

Variation in assay sensitivity was studied in more than 90 laboratories that assayed 4formalin-fixed, paraffin-processed breast and ovarian carcinoma cell lines with graded levels of HER-2/neu protein overexpression and known levels of HER-2/neu gene... Read More about Evaluation of HER-2/neu immunohistochemical assay sensitivity and scoring on formalin-fixed and paraffin-processed cell lines and breast tumors: A comparative study involving results from laboratories in 21 countries.