Outputs (14)

The influence of molecular Hydrogen therapies in managing the symptoms of acute and chronic COVID-19 (2022)
Journal Article
Russell, G., Thomas, A., Nenov, A., & Hancock, J. (2022). The influence of molecular Hydrogen therapies in managing the symptoms of acute and chronic COVID-19. Medical Research Archives, 10(9), https://doi.org/10.18103/mra.v10i9.3036

Coronavirus Infectious Disease 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2) that emerged as a novel pathogen of global concern in the latter stages of 2019. COVID-19 is a highly contagio... Read More about The influence of molecular Hydrogen therapies in managing the symptoms of acute and chronic COVID-19.

MicroRNAs and the DNA damage response: How is cell fate determined? (2021)
Journal Article
Visser, H., & Thomas, A. D. (2021). MicroRNAs and the DNA damage response: How is cell fate determined?. DNA Repair, 108, Article 103245. https://doi.org/10.1016/j.dnarep.2021.103245

It is becoming clear that the DNA damage response orchestrates an appropriate response to a given level of DNA damage, whether that is cell cycle arrest and repair, senescence or apoptosis. It is plausible that the alternative regulation of the DNA d... Read More about MicroRNAs and the DNA damage response: How is cell fate determined?.

Molecular hydrogen: Is this a viable new treatment for plants in the UK? (2021)
Journal Article
Hancock, J. T., LeBaron, T. W., May, J., Thomas, A., & Russell, G. (2021). Molecular hydrogen: Is this a viable new treatment for plants in the UK?. Plants, 10(11), Article 2270

Despite being trialed in other regions of the world, the use of molecular hydrogen (H2) for enhanced plant growth and postharvest storage of crops has yet to be widely accepted in the UK. The evidence continues to grow that treatment of plants and pl... Read More about Molecular hydrogen: Is this a viable new treatment for plants in the UK?.

MicroRNAs, damage levels, and DNA damage response control (2021)
Journal Article
Visser, H., & Thomas, A. D. (2021). MicroRNAs, damage levels, and DNA damage response control. Trends in Genetics, 37(11), 963-965. https://doi.org/10.1016/j.tig.2021.06.018

DNA damage–inducible miRNAs are likely to be functional in the DNA damage response. This response can elicit damage resolution and cell survival or apoptosis. The current, albeit incomplete, picture suggests that miRNAs can affect cell fate via modul... Read More about MicroRNAs, damage levels, and DNA damage response control.

Estragole: DNA adduct formation in primary rat hepatocytes and genotoxic potential in HepG2-CYP1A2 cells (2020)
Journal Article
Schulte-Hubbert, R., Küpper, J. H., Thomas, A. D., & Schrenk, D. (2020). Estragole: DNA adduct formation in primary rat hepatocytes and genotoxic potential in HepG2-CYP1A2 cells. Toxicology, 444, Article 152566. https://doi.org/10.1016/j.tox.2020.152566

Estragole is a natural constituent in herbs and spices and in products thereof such as essential oils or herbal teas. After cytochrome P450-catalyzed hydroxylation and subsequent sulfation, estragole acts as a genotoxic hepatocarcinogen forming DNA a... Read More about Estragole: DNA adduct formation in primary rat hepatocytes and genotoxic potential in HepG2-CYP1A2 cells.

Immunological and mass spectrometry-based approaches to determine thresholds of the mutagenic DNA adduct O 6 -methylguanine in vivo (2018)
Journal Article
Kraus, A., McKeague, M., Seiwert, N., Nagel, G., Geisen, S. M., Ziegler, N., …Fahrer, J. (2019). Immunological and mass spectrometry-based approaches to determine thresholds of the mutagenic DNA adduct O 6 -methylguanine in vivo. Archives of Toxicology, 93(2), 559-572. https://doi.org/10.1007/s00204-018-2355-0

© 2018, Springer-Verlag GmbH Germany, part of Springer Nature. N-nitroso compounds are alkylating agents, which are widespread in our diet and the environment. They induce DNA alkylation adducts such as O 6 -methylguanine (O 6 -MeG), which is repair... Read More about Immunological and mass spectrometry-based approaches to determine thresholds of the mutagenic DNA adduct O 6 -methylguanine in vivo.

Genetic toxicity assessment of engineered nanoparticles using a 3D in vitro skin model (EpiDerm ™ ) (2016)
Journal Article
Wills, J. W., Hondow, N., Thomas, A. D., Chapman, K. E., Fish, D., Maffeis, T. G., …Doak, S. H. (2016). Genetic toxicity assessment of engineered nanoparticles using a 3D in vitro skin model (EpiDerm ™ ). Particle and Fibre Toxicology, 13, Article 50. https://doi.org/10.1186/s12989-016-0161-5

© 2016 The Author(s). Background: The rapid production and incorporation of engineered nanomaterials into consumer products alongside research suggesting nanomaterials can cause cell death and DNA damage (genotoxicity) makes in vitro assays desirabl... Read More about Genetic toxicity assessment of engineered nanoparticles using a 3D in vitro skin model (EpiDerm ™ ).

DNA damage and the balance between survival and death in cancer biology (2016)
Journal Article
Roos, W. P., Thomas, A. D., & Kaina, B. (2016). DNA damage and the balance between survival and death in cancer biology. Nature Reviews Cancer, 16(1), 20-33. https://doi.org/10.1038/nrc.2015.2

© 2016 Macmillan Publishers Limited. DNA is vulnerable to damage resulting from endogenous metabolites, environmental and dietary carcinogens, some anti-inflammatory drugs, and genotoxic cancer therapeutics. Cells respond to DNA damage by activating... Read More about DNA damage and the balance between survival and death in cancer biology.

DNA repair by MGMT, but not AAG, causes a threshold in alkylation-induced colorectal carcinogenesis (2015)
Journal Article
Fahrer, J., Frisch, J., Nagel, G., Kraus, A., Dörsam, B., Thomas, A. D., …Kaina, B. (2015). DNA repair by MGMT, but not AAG, causes a threshold in alkylation-induced colorectal carcinogenesis. Carcinogenesis, 36(10), 1235-1244. https://doi.org/10.1093/carcin/bgv114

© The Author 2015. Published by Oxford University Press. All rights reserved. Epidemiological studies indicate that N-nitroso compounds (NOC) are causally linked to colorectal cancer (CRC). NOC induce DNA alkylations, including O6-methylguanine (O6-M... Read More about DNA repair by MGMT, but not AAG, causes a threshold in alkylation-induced colorectal carcinogenesis.

Theoretical considerations for thresholds in chemical carcinogenesis (2015)
Journal Article
Thomas, A. D., Fahrer, J., Johnson, G., & Kaina, B. (2015). Theoretical considerations for thresholds in chemical carcinogenesis. Mutation Research - Reviews, 765, 56-67. https://doi.org/10.1016/j.mrrev.2015.05.001

© 2015 Elsevier B.V. There is increasing evidence for non-linear relationships for gene mutations, chromosomal aberrations and even tumor incidences in response to low doses of genotoxic carcinogens. To attain the biological relevance of such non-lin... Read More about Theoretical considerations for thresholds in chemical carcinogenesis.