Promoting access to haemostasis testing in resource-scarce and emergency settings using paper-based lateral flow diagnostic screening assays for coagulation disorders (2023)
Thesis
Saidykhan, J. Promoting access to haemostasis testing in resource-scarce and emergency settings using paper-based lateral flow diagnostic screening assays for coagulation disorders. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/10774108

Haemostatic disorders cause excessive bleeding and clotting and result in high morbidity and mortality worldwide, but especially in low-income areas which often lack suitable facilities and expertise for affordable diagnosis and treatment. Simple and... Read More about Promoting access to haemostasis testing in resource-scarce and emergency settings using paper-based lateral flow diagnostic screening assays for coagulation disorders.

Metabolic reprogramming and the role of the BCAT protein - implications for type 2 diabetes and Alzheimer's disease (2023)
Thesis
Usmari Moraes, M. Metabolic reprogramming and the role of the BCAT protein - implications for type 2 diabetes and Alzheimer's disease. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/10013675

Introduction: Oxidative stress and impaired homeostasis are key features of type 2 diabetes mellitus, which is comorbid with Alzheimer’s disease. Dysregulation of the branched-chain aminotransferase protein, which is overexpressed in AD, is suggested... Read More about Metabolic reprogramming and the role of the BCAT protein - implications for type 2 diabetes and Alzheimer's disease.

Investigating the disease-promoting abilities of gut bacteria in colorectal tumour cells (2021)
Thesis
Robson, J. Investigating the disease-promoting abilities of gut bacteria in colorectal tumour cells. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/7434617

Colorectal cancer (CRC) is the third most common malignancy worldwide and the second leading cause of cancer-related death. The global burden of CRC is rising, particularly in younger populations. This increase has been attributed to lifestyle factor... Read More about Investigating the disease-promoting abilities of gut bacteria in colorectal tumour cells.

Targeting the splice factor kinases SRPK1 and CLK1 in leukaemia (2021)
Thesis
Wodi, C. Targeting the splice factor kinases SRPK1 and CLK1 in leukaemia. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/1490771

This study was aimed at investigating the effect of inhibiting SRPK1 in leukaemic cells. It was also aimed at exploring the potential utility of combining conventional leukaemia chemotherapy (such as imatinib) with compounds that inhibit SRPK1. SR... Read More about Targeting the splice factor kinases SRPK1 and CLK1 in leukaemia.

Marker development for the traceability of certified sustainably produced cacao (Theobroma cacao) in the chocolate industry (2021)
Thesis
Lafargue, P. Marker development for the traceability of certified sustainably produced cacao (Theobroma cacao) in the chocolate industry. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/6642792

Theobroma cacao (cocoa) is one of the most studied commodities around the world and the source of one of the world’s most consumed and familiar products, chocolate. The multibillion-pound industry has changed to a higher demand for sustainably certif... Read More about Marker development for the traceability of certified sustainably produced cacao (Theobroma cacao) in the chocolate industry.

Exploration of the possible role of microRNA(s) and small extracellular vesicles in chemotherapy-induced bystander effects (2021)
Thesis
Ude, A. Exploration of the possible role of microRNA(s) and small extracellular vesicles in chemotherapy-induced bystander effects. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/6971684

Advances in modern chemotherapeutic regimens have led to an increase in the overall survival of leukaemia patients in recent years. However, haematopoietic stem cell transplantation (HSCT) remains the curative option for these patients. In HSCT, high... Read More about Exploration of the possible role of microRNA(s) and small extracellular vesicles in chemotherapy-induced bystander effects.

The role of hBCATc in breast cancer progression through IGF-1 and insulin signalling cascades (2020)
Thesis
Shafei, M. The role of hBCATc in breast cancer progression through IGF-1 and insulin signalling cascades. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/3429539

Introduction and Aims: Breast cancer remains the leading cause of cancer mortality in women globally, despite advances in the development of targeted therapies. Driven by oncogenic signals, cancer cells undergo metabolic reprogramming, upregulatin... Read More about The role of hBCATc in breast cancer progression through IGF-1 and insulin signalling cascades.

Alcohol and micronutrient-induced regulation of Aβ load and Tau hyperphosphorylation through modulation of mitochondrial fusion/fission pathways (2020)
Thesis
Okoro, G. U. Alcohol and micronutrient-induced regulation of Aβ load and Tau hyperphosphorylation through modulation of mitochondrial fusion/fission pathways. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/1491050

Introduction and aims: Alzheimer’s disease (AD) has for decades been associated with increased accumulation of brain amyloid β peptides (Aβ) and phosphorylated tau. Unfortunately, targeted therapy to Aβ in particular has not been successful resulting... Read More about Alcohol and micronutrient-induced regulation of Aβ load and Tau hyperphosphorylation through modulation of mitochondrial fusion/fission pathways.

Fenofibrate toxicity and impact on clinical biomarkers in patients with dyslipidaemia (2020)
Thesis
Fombon, I. Fenofibrate toxicity and impact on clinical biomarkers in patients with dyslipidaemia. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/3829730

Introduction and aims: Fenofibrate is the most widely used fibric acid derivative for managing mixed dyslipidaemia, characterised by elevated levels of cholesterol, triglycerides and LDL cholesterol and low levels of HDL cholesterol. Fenofibrate is a... Read More about Fenofibrate toxicity and impact on clinical biomarkers in patients with dyslipidaemia.

Chemotherapy induces a genotoxic bystander effect in cell lines from the human bone marrow; evaluation of the role of the redox microenvironment (2020)
Thesis
Okeke, K. Chemotherapy induces a genotoxic bystander effect in cell lines from the human bone marrow; evaluation of the role of the redox microenvironment. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/2812709

Modern chemotherapeutic regimens for adult and childhood leukaemia rely on the use of a combination of various cytotoxic agents. Unfortunately, haematopoietic stem cell transplant, a last resort treatment for haematologic malignancies requires high d... Read More about Chemotherapy induces a genotoxic bystander effect in cell lines from the human bone marrow; evaluation of the role of the redox microenvironment.

In vitro modelling of tongue derived microbial biofilms and their reponse to treatment (2020)
Thesis
Hewett, K. E. In vitro modelling of tongue derived microbial biofilms and their reponse to treatment. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/1491292

This work concerns the development of a flat plate perfusion model to study biofilms derived from human tongue biota. The model has been derived from a previous sorbarod model, via a flat plate model (used to study wound organisms), to the model desc... Read More about In vitro modelling of tongue derived microbial biofilms and their reponse to treatment.

Targeting the splice factor kinase CLK1 in prostate cancer cells (2020)
Thesis
Uzor, S. O. Targeting the splice factor kinase CLK1 in prostate cancer cells. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/1490733

Prostate cancer is the most rampant diagnosed cancer and the second leading cause of cancer related death in men between middle age and old age. There is a need to identify the molecular genetic processes that underpin prostate cancer and to search f... Read More about Targeting the splice factor kinase CLK1 in prostate cancer cells.

Antimicrobial activity of essential oils as liquid and vapour applications (2020)
Thesis
Elcocks, E. R. (2020). Antimicrobial activity of essential oils as liquid and vapour applications. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/1490727

Essential oils produced by plants have been used as antimicrobial agents historically, however, many essential oils remain under-exploited as alternatives to antimicrobials. Therefore, the aim of this thesis was to evaluate the antibacterial efficacy... Read More about Antimicrobial activity of essential oils as liquid and vapour applications.

The development of point-of-use treatment technologies for the production of drinking water (2019)
Thesis
Clayton, G. The development of point-of-use treatment technologies for the production of drinking water. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/1490721

An estimated 884 million people worldwide lack access to drinking water from improved water sources. With the global population expected to reach eleven billion by the end of the 21st Century, stress on water and energy resources will be exacerbated.... Read More about The development of point-of-use treatment technologies for the production of drinking water.

New approaches to the detection of echinocandin resistance in Candida glabrata in clinical diagnostic laboratories (2019)
Thesis
Fraser, M. A. New approaches to the detection of echinocandin resistance in Candida glabrata in clinical diagnostic laboratories. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/1490747

Candidaemia is widely reported as the fourth most common form of bloodstream infection worldwide. Reports of cases of candidaemia whilst patients are in receipt of antifungal therapy are increasing, and this is especially relevant as prescribing prac... Read More about New approaches to the detection of echinocandin resistance in Candida glabrata in clinical diagnostic laboratories.

Developmental, morphological and physiological effects of chronic low doses of ionising radiation on plants on earth and in space (2019)
Thesis
Caplin, N. M. Developmental, morphological and physiological effects of chronic low doses of ionising radiation on plants on earth and in space. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/1491172

Conclusions in the current literature are essentially unanimous regarding what is known about the effects of ionising radiation on plants. It is agreed that acute high-dose effects (primarily from laboratory tests) are well-documented and understood... Read More about Developmental, morphological and physiological effects of chronic low doses of ionising radiation on plants on earth and in space.

An investigation into the regulation of transcription of the splice factor kinase gene SRPK1 in prostate and leukaemia cancer cell lines (2019)
Thesis
Belali, T. An investigation into the regulation of transcription of the splice factor kinase gene SRPK1 in prostate and leukaemia cancer cell lines. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/1490649

The SRPK1 gene encodes a protein kinase that phosphorylates a class of splice factors called serine/arginine-rich proteins (SR proteins) modifying their ability to regulate alternative pre-mRNA splicing. Studies have linked high SRPK1 levels to tumou... Read More about An investigation into the regulation of transcription of the splice factor kinase gene SRPK1 in prostate and leukaemia cancer cell lines.

The role of ABA in regulating the movemement of chlamydomonas reinhardtii in response to stress (2019)
Thesis
Alhijab, L. The role of ABA in regulating the movemement of chlamydomonas reinhardtii in response to stress. (Thesis). The West England University. Retrieved from https://uwe-repository.worktribe.com/output/1492927

Plant hormones such as auxin, gibberellin, cytokinin, ethylene, and abscisic acid play key roles in growth and developmental processes in higher plants such as Arabidopsis thaliana. However, the effect of these hormones on algal physiology is still u... Read More about The role of ABA in regulating the movemement of chlamydomonas reinhardtii in response to stress.

Bird's nest ferns as model systems and conservation tools (2019)
Thesis
Phillips, J. Bird's nest ferns as model systems and conservation tools. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/846445

We are in a race against time to understand the response of natural systems to climate change and anthropogenic disturbances, such as large scale land conversion for oil palm expansion. However, it is incredibly difficult to quantify multi-trophic bi... Read More about Bird's nest ferns as model systems and conservation tools.

Investigations into novel electrochemical technology for boar taint detection and vitamin analysis (2019)
Thesis
Westmacott, K. Investigations into novel electrochemical technology for boar taint detection and vitamin analysis. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/853351

This thesis presents the evaluation of the novel electrochemical sensor and biosensor technology developed for the direct analysis of boar taint compounds in adipose tissue (European Patent 2966441). Gas chromatographic methods and extraction procedu... Read More about Investigations into novel electrochemical technology for boar taint detection and vitamin analysis.