Interaction of nitric oxide with auxin and ethylene signalling in Arabidopsis root gravitropism (2017)
Thesis
Vembu, K. Interaction of nitric oxide with auxin and ethylene signalling in Arabidopsis root gravitropism. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/877297

Gravitropism is required for the appropriate alignment of the plant root and shoot. According to the Cholodny-Went hypothesis, gravity induces asymmetric accumulation of auxin in the lower side of the root tissue. More recent studies on root gravitro... Read More about Interaction of nitric oxide with auxin and ethylene signalling in Arabidopsis root gravitropism.

Quantum pathogen evolution by integron-mediated effector capture (2017)
Thesis
Payne, J. D. Quantum pathogen evolution by integron-mediated effector capture. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/877432

Plant pathogenic Pseudomonads are responsible for the loss of millions of pounds in crop revenue each year. They export effector molecules via the type three secretion system into the plants’ cells in order to elicit disease. If the plant has the cor... Read More about Quantum pathogen evolution by integron-mediated effector capture.

Targeting splice factor kinases and their splice factor in chronic myeloid leukaemia (2017)
Thesis
Alabouh, H. Targeting splice factor kinases and their splice factor in chronic myeloid leukaemia. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/879470

Alternative splicing of pre-mRNA is a ubiquitous and versatile mechanism controlling the expression of human genes. In humans, approximately 93% of multi-exonic genes are alternatively spliced, producing functionally distinct proteins. Dysregulation... Read More about Targeting splice factor kinases and their splice factor in chronic myeloid leukaemia.

The effect of hypoxia on alternative splicing in prostate cancer cell lines (2017)
Thesis
Bowler, E. The effect of hypoxia on alternative splicing in prostate cancer cell lines. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/879763

Hypoxia is defined as the state in which the availability or delivery of oxygen is insufficient to meet tissue demand. It occurs particularly in aggressive, fast-growing tumours in which the rate of new blood vessel formation (angiogenesis) cannot ma... Read More about The effect of hypoxia on alternative splicing in prostate cancer cell lines.

Genotoxicity and functionality assessment of a bone marrow stromal cell line following chemotherapy exposure in an in vitro model of multiple myeloma (2017)
Thesis
Andrews, S. W. Genotoxicity and functionality assessment of a bone marrow stromal cell line following chemotherapy exposure in an in vitro model of multiple myeloma. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/887562

Multiple myeloma (MM) is a haematological malignancy characterized by terminally differentiated plasma cells and their accumulation in the bone marrow (BM). Despite significant advances in therapeutic strategies it currently remains incurable. The in... Read More about Genotoxicity and functionality assessment of a bone marrow stromal cell line following chemotherapy exposure in an in vitro model of multiple myeloma.

Redox binding partners of the hBCAT proteins and their distribution and expression in control and disease human brains: Implications in protein folding in neurodegeneration (2017)
Thesis
Lee, C. Redox binding partners of the hBCAT proteins and their distribution and expression in control and disease human brains: Implications in protein folding in neurodegeneration. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/888429

INTRODUCTION: Novel binding partners of the branched chain aminotransferase proteins (hBCAT) proteins have been identified and indicate that these metabolic proteins may have alternative functions to their housekeeping role. In particular, the molecu... Read More about Redox binding partners of the hBCAT proteins and their distribution and expression in control and disease human brains: Implications in protein folding in neurodegeneration.

The role of increased hBCATm in the endothelial cells of patients with Alzheimer’s disease (2017)
Thesis
The role of increased hBCATm in the endothelial cells of patients with Alzheimer’s disease. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/897571

Introduction and aims: The branched-chain aminotransferase (BCAT) enzymes are important in the regulation of brain L-glutamate. A unique function of these aminotransferases is their regulation by the redox environment, where our group have shown thei... Read More about The role of increased hBCATm in the endothelial cells of patients with Alzheimer’s disease.

The role of dysregulated autophagy in Alzheimer's disease (2017)
Thesis
Harris, M. N. The role of dysregulated autophagy in Alzheimer's disease. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/897691

Introduction: The accumulation of misfolded Aβ and phospho-tau are characteristic features of Alzheimer’s disease (AD) pathology. One of the cellular mechanisms responsible for the removal of these aggregates is autophagy, where proteins and organel... Read More about The role of dysregulated autophagy in Alzheimer's disease.

The development of a point of care device for measuring blood ammonia (2017)
Thesis
Brannelly, N. The development of a point of care device for measuring blood ammonia. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/900674

Ammonia is produced in the body during the metabolism of amino acids. In the liver, it is converted to urea via the urea cycle and excreted by the kidneys as urine. Normal levels are between 11 to 50 µM, whereas a blood ammonia level of approximately... Read More about The development of a point of care device for measuring blood ammonia.

The role of beta-cell glutamate receptors in pancreatic endocrine function and in the pathogenesis of type 1 diabetes mellitus (2017)
Thesis
Dwomoh, L. The role of beta-cell glutamate receptors in pancreatic endocrine function and in the pathogenesis of type 1 diabetes mellitus. (Thesis). University of the West of England. Retrieved from https://uwe-repository.worktribe.com/output/900722

Background: Kainate receptors (KARs) are one of the three classes of ionotropic glutamate receptors (iGluRs) expressed primarily in the central nervous system (CNS) where they mediate information transfer and neurotransmitter release. Very little is... Read More about The role of beta-cell glutamate receptors in pancreatic endocrine function and in the pathogenesis of type 1 diabetes mellitus.