Manometry performed at indwelling pleural catheter insertion to predict unexpandable lung (2020)
Journal Article

Background: The finding of unexpandable lung (UL) at an early timepoint is of increasing importance in guiding treatment decisions in patients with malignant pleural effusion (MPE). Pleural manometry is the most common technique to delineate UL, howe... Read More about Manometry performed at indwelling pleural catheter insertion to predict unexpandable lung.

Parametric and non-parametric tests for the comparison of two samples which both include paired and unpaired observations (2019)
Journal Article

Samples that include both independent and paired observations cause a dilemma for researchers that covers the full breadth of empirical research. Parametric approaches for the comparison of two samples using all available observations are considered,... Read More about Parametric and non-parametric tests for the comparison of two samples which both include paired and unpaired observations.

Methods for comparing the responses from a Likert question, with paired observations and independent observations in each of two samples (2018)
Journal Article

Assesses the robustness of the partially overlapping samples t-tests for ordinal samples. Introduces the Derrick-White Type I error robustness criteria.

Establishing the usefulness of the GO-QOL in a UK hospital-treated population with thyroid eye disease in the CIRTED trial (2018)
Journal Article

© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. Thyroid eye disease (TED) is a potentially sight-threatening and cosmetically disfiguring condition arising in 25–50% of patients with Graves’ hyperthyroidism. CIRTED is the fir... Read More about Establishing the usefulness of the GO-QOL in a UK hospital-treated population with thyroid eye disease in the CIRTED trial.

Results of a randomized, double blind, placebo controlled, crossover trial of melatonin for treatment of Nocturia in adults with multiple sclerosis (MeNiMS) (2018)
Journal Article

© 2018 The Author(s). Background: Nocturia is a common urinary symptom of multiple sclerosis (MS) which can affect quality of life (QoL) adversely. Melatonin is a hormone known to regulate circadian rhythm and reduce smooth muscle activity such as in... Read More about Results of a randomized, double blind, placebo controlled, crossover trial of melatonin for treatment of Nocturia in adults with multiple sclerosis (MeNiMS).

Recurrence rates in primary spontaneous pneumothorax: A systematic review and meta-analysis (2018)
Journal Article

Copyright ©ERS 2018 Primary spontaneous pneumothorax (PSP) recurrence rates vary widely in the published literature, with limited data describing the factors that influence recurrence. The aims of this systematic review were to determine an estimati... Read More about Recurrence rates in primary spontaneous pneumothorax: A systematic review and meta-analysis.

Preschool children’s communication, motor and social development: Parents’ and educators’ concerns (2018)
Journal Article

© 2017, © 2017 The Speech Pathology Association of Australia Limited. Purpose: During early childhood, it is important to identify which children require intervention before they face the increased demands of school. This study aimed to: (1) compare... Read More about Preschool children’s communication, motor and social development: Parents’ and educators’ concerns.

Tests for equality of variances between two samples which contain both paired observations and independent observations (2018)
Journal Article

Tests for equality of variances between two samples which contain both paired observations and independent observations are explored using simulation. New solutions which make use of all of the available data are put forward. These new approaches are... Read More about Tests for equality of variances between two samples which contain both paired observations and independent observations.

Upfront docetaxel with androgen deprivation therapy in the elderly patient with metastatic hormone-naïve prostate cancer: Single institution experience (2018)
Journal Article

Upfront docetaxel with androgen deprivation therapy in the elderly patient with metastatic hormone-naïve prostate cancer: Single institution experience

Predictors of improved biochemical progression free survival for salvage prostate bed radiotherapy after radical prostatectomy (2018)
Journal Article

Predictors of improved biochemical progression free survival for salvage prostate bed radiotherapy after radical prostatectomy

18 F-Fluorodeoxyglucose PET/CT and dynamic contrast-enhanced MRI as imaging biomarkers in malignant pleural mesothelioma (2018)
Journal Article

© 2018 Wolters Kluwer Health, Inc. All rights reserved. Purpose The purpose of this study was to compare the use of fluorine-18-fluorodeoxyglucose (18 F-FDG) PET with computed tomography (CT) and dynamic contrast-enhanced (DCE) MRI to predict prognos... Read More about 18 F-Fluorodeoxyglucose PET/CT and dynamic contrast-enhanced MRI as imaging biomarkers in malignant pleural mesothelioma.

The impact of an extreme observation in a paired samples design (2017)
Journal Article

The effect of systematically altering the value of a single observation within a paired differences design is considered. A paradox is observed for the paired samples t-test, where increasing the value of an observation in the direction of the true m... Read More about The impact of an extreme observation in a paired samples design.

Cluster-randomized controlled trial evaluating the effectiveness of computer-assisted intervention delivered by educators for children with speech sound disorders (2017)
Journal Article

© 2017 American Speech-Language-Hearing Association. Purpose: The aim was to evaluate the effectiveness of computer-assisted input-based intervention for children with speech sound disorders (SSD). Method: The Sound Start Study was a cluster-randomiz... Read More about Cluster-randomized controlled trial evaluating the effectiveness of computer-assisted intervention delivered by educators for children with speech sound disorders.

A comparison of analytical methods for the two group pre- post design (2017)
Presentation / Conference Contribution

Simulation demonstrates that for a two group randomized design ANCOVA is more powerful than the gain score approach For ANCOVA with an interaction term the model with pre scores X as a covariate is more powerful than the model with X + Y as the co... Read More about A comparison of analytical methods for the two group pre- post design.

Protocol for a randomized, double blind, placebo controlled, crossover trial of Melatonin for treatment of Nocturia in adults with Multiple Sclerosis (MeNiMS) (2017)
Journal Article

© 2017 The Author(s). Background: Nocturia (the symptom of needing to wake up to pass urine) is common in progressive Multiple Sclerosis (MS) patients. Moderate-to-severe nocturia affects quality of life, can exacerbate fatigue and may affect capacit... Read More about Protocol for a randomized, double blind, placebo controlled, crossover trial of Melatonin for treatment of Nocturia in adults with Multiple Sclerosis (MeNiMS).

Minimum 20-year survivorship of the St Georg Sled medial unicompartmental knee replacement (2017)
Journal Article

Minimum 20-year survivorship of the St Georg Sled medial unicompartmental knee replacement

The transcription factor PPARα is overexpressed and is associated with a favourable prognosis in IDH-wildtype primary glioblastoma (2016)
Journal Article

© 2016 John Wiley & Sons Ltd Aims: PPARα agonists are in current clinical use as hypolipidaemic agents and show significant antineoplastic effects in human glioblastoma models. To date however, the expression of PPARα in large-scale glioblastoma da... Read More about The transcription factor PPARα is overexpressed and is associated with a favourable prognosis in IDH-wildtype primary glioblastoma.

Test statistics for comparing two proportions with partially overlapping samples (2015)
Journal Article

Standard tests for comparing two sample proportions of a dichotomous dependent variable where there is a combination of paired and unpaired samples are considered. Four new tests are introduced and compared against standard tests and an alternative p... Read More about Test statistics for comparing two proportions with partially overlapping samples.

Cardiopulmonary reserve as determined by cardiopulmonary exercise testing correlates with length of stay and predicts complications after radical cystectomy (2015)
Journal Article

© 2014 The Authors. BJU International © 2014 BJU International. ObjectiveTo investigate whether poor preoperative cardiopulmonary reserve and comorbid state dictate high-risk status and can predict complications in patients undergoing radical cystect... Read More about Cardiopulmonary reserve as determined by cardiopulmonary exercise testing correlates with length of stay and predicts complications after radical cystectomy.

The South West Area Mesothelioma and Pemetrexed trial: A multicentre prospective observational study evaluating novel markers of chemotherapy response and prognostication (2015)
Journal Article

© 2015 Cancer Research UK. All rights reserved. Background: Robust markers that predict prognosis and detect early treatment response in malignant pleural mesothelioma (MPM) would enhance patient care. Methods: Consecutive patients with MPM who were... Read More about The South West Area Mesothelioma and Pemetrexed trial: A multicentre prospective observational study evaluating novel markers of chemotherapy response and prognostication.