David O Hall
18 F-Fluorodeoxyglucose PET/CT and dynamic contrast-enhanced MRI as imaging biomarkers in malignant pleural mesothelioma
Hall, David O; Hooper, Clare E; Searle, Julie; Darby, Michael; White, Paul; Harvey, John E; Braybrooke, Jeremy P; Maskell, Nick A; Masani, Vidan; Lyburn, Iain D
Authors
Clare E Hooper
Julie Searle
Michael Darby
Paul White Paul.White@uwe.ac.uk
Professor in Applied Statistics
John E Harvey
Jeremy P Braybrooke
Nick A Maskell
Vidan Masani
Iain D Lyburn
Abstract
© 2018 Wolters Kluwer Health, Inc. All rights reserved. Purpose The purpose of this study was to compare the use of fluorine-18-fluorodeoxyglucose (18 F-FDG) PET with computed tomography (CT) and dynamic contrast-enhanced (DCE) MRI to predict prognosis and monitor treatment in malignant pleural mesothelioma. Patients and methods 18 F-FDG PET/CT and DCE-MRI studies carried out as part of the South West Area Mesothelioma Pemetrexed trial were used. 18 F-FDG PET/CT and DCE-MRI studies were carried out before treatment, and after two cycles of chemotherapy, on patients treated with pemetrexed and cisplatin. A total of 73 patients were recruited, of whom 65 had PET/CT and DCE-MRI scans. Baseline measurements from 18 F-FDG PET/CT (maximum standardized uptake value, metabolic tumour volume and total lesion glycolysis) and DCE-MRI (integrated area under the first 90s of the curve and washout slope) were compared with overall survival (OS) using Kaplan-Meier and Cox regression analyses, and changes in imaging measurements were compared with disease progression. Results PET/CT and DCE-MRI measurements were not correlated with each other. Maximum standardized uptake value, metabolic tumour volume and total lesion glycolysis were significantly related to OS with Cox regression analysis and Kaplan-Meir analysis, and DCE-MRI washout curve shape was significantly related to OS. DCE-MRI curve shape can be combined with 18 F-FDG PET/CT to give additional prognostic information. Changes in measurements were not related to progression-free survival. Conclusions 18 F-FDG PET/CT and DCE-MRI give prognostic information in malignant pleural mesothelioma. Neither PET/CT nor DCE-MRI is useful for monitoring disease progression.
Journal Article Type | Article |
---|---|
Acceptance Date | Nov 27, 2017 |
Publication Date | Jan 1, 2018 |
Deposit Date | Jan 19, 2018 |
Publicly Available Date | Jan 24, 2018 |
Journal | Nuclear Medicine Communications |
Print ISSN | 0143-3636 |
Electronic ISSN | 1473-5628 |
Publisher | Lippincott, Williams & Wilkins |
Peer Reviewed | Peer Reviewed |
Volume | 39 |
Issue | 2 |
Pages | 161-170 |
DOI | https://doi.org/10.1097/MNM.0000000000000789 |
Keywords | 18F-Fluorodeoxyglucose, PET/CT, dynamic, contrast-enhanced, MRI, imaging biomarkers, malignant, pleural mesothelioma |
Public URL | https://uwe-repository.worktribe.com/output/874224 |
Publisher URL | https://journals.lww.com/nuclearmedicinecomm/Citation/2018/02000/18F_Fluorodeoxyglucose_PET_CT_and_dynamic.10.aspx |
Additional Information | Additional Information : This is the author's accepted manuscript. The final, published version is available at https://journals.lww.com/nuclearmedicinecomm/Citation/2018/02000/18F_Fluorodeoxyglucose_PET_CT_and_dynamic.10.aspx |
Contract Date | Jan 24, 2018 |
Files
D Hall NMC-SWAMP_accepted.pdf
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