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The design, development and application of electrochemical glutamate biosensors

Hughes, G.; Pemberton, R. M.; Hart, J. P.; Hughes, Gareth; Pemberton, Roy; Hart, John P.; Fielden, P. R.


G. Hughes

R. M. Pemberton

J. P. Hart

Gareth Hughes

P. R. Fielden


The development of biosensors for the determination of glutamate has been of great research interest for the past 25 years due to its importance in biomedical and food studies. This review focusses on the various strategies used to fabricate glutamate biosensors as well as their performance characteristics. A brief comparison of the enzyme immobilisation method employed and the performance characteristics of a range of glutamate biosensors are described in tabular form and then described in detail throughout the review: some selected examples have been included to demonstrate the various applications of these biosensors to real samples.


Hughes, G., Pemberton, R., Fielden, P., & Hart, J. P. (2016). The design, development and application of electrochemical glutamate biosensors. Trends in Analytical Chemistry, 79, 106-113.

Journal Article Type Article
Acceptance Date Oct 6, 2015
Online Publication Date Dec 8, 2015
Publication Date Jan 1, 2016
Journal TrAC Trends in Analytical Chemistry
Print ISSN 0165-9936
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 79
Pages 106-113
Keywords glutamate oxidase, glutamate dehydrogenase, monosodium glutamate, amperometry, carbon nanotubes, reagentless, biosensor, NADH, NAD+, differential pulse voltammetry
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