A copper oxide/zinc oxide composite nano-surface for use in a biosensor

Cao, Lu; Kiely, Janice; Piano, Martina; Luxton, Richard

Abstract

© 2019 by the authors. In this study, biosensors based on zinc oxide-copper oxide composite nano-surfaces were prepared using a simple and inexpensive distributed colloidal technique. Combinations of mixed dispersions with volume ratios of 1:1, 1:2 and 2:1 ZnO:CuO were compared. The uniform nano-crystalline sensor surfaces on polyethylene terephthalate (PET) were analysed using scanning electron microscopy (SEM), Atomic Force Microscopy (AFM) and Raman Spectroscopy. The ZnO-CuO composite biosensor nano-surfaces showed a significantly increased impedimetric signal compared with pure ZnO nanocrystals, and the maximum output was achieved with a volume ratio of 1:2 ZnO/CuO. The antibody capture of C-reactive protein (CRP) on the nano-surfaces was used to demonstrate the enhanced signal generated with increasing amounts of CuO in the nano-surface.

• Journal Article Type: Article
• Acceptance Date: Apr 2, 2019
• Publication Date: Apr 6, 2019
• Deposit Date: May 31, 2019
• Publicly Available Date: May 31, 2019
• Journal: Materials
• Print ISSN: 1996-1944
• Electronic ISSN: 1996-1944
• Publisher: MDPI
• Peer Reviewed: Peer Reviewed
• Volume: 12
• Issue: 7
• Pages: 1126
• DOI: https://doi.org/10.3390/ma12071126
• Keywords: biosensor; impedance; ZnO–CuO; CRP
• Public URL: https://uwe-repository.worktribe.com/output/849023
• Publisher URL: https://doi.org/10.3390/ma12071126
• Contract Date: May 31, 2019