A copper oxide/zinc oxide composite nano-surface for use in a biosensor

Cao, Lu; Kiely, Janice; Piano, Martina; Luxton, Richard

doi:10.3390/ma12071126

A copper oxide/zinc oxide composite nano-surface for use in a biosensor

Cao, Lu; Kiely, Janice; Piano, Martina; Luxton, Richard

Authors

Lu Cao

Janice Kiely Janice.Kiely@uwe.ac.uk
Professor in Bio-electronics/Res In CoDi

Martina Piano Martina.Piano@uwe.ac.uk
Research Fellow Biosensor reproducibility testing

Richard Luxton Richard.Luxton@uwe.ac.uk
Research Centre Director-IBST/Professor

Abstract

© 2019 by the authors. In this study, biosensors based on zinc oxide-copper oxide composite nano-surfaces were prepared using a simple and inexpensive distributed colloidal technique. Combinations of mixed dispersions with volume ratios of 1:1, 1:2 and 2:1 ZnO:CuO were compared. The uniform nano-crystalline sensor surfaces on polyethylene terephthalate (PET) were analysed using scanning electron microscopy (SEM), Atomic Force Microscopy (AFM) and Raman Spectroscopy. The ZnO-CuO composite biosensor nano-surfaces showed a significantly increased impedimetric signal compared with pure ZnO nanocrystals, and the maximum output was achieved with a volume ratio of 1:2 ZnO/CuO. The antibody capture of C-reactive protein (CRP) on the nano-surfaces was used to demonstrate the enhanced signal generated with increasing amounts of CuO in the nano-surface.

Journal Article Type	Article
Acceptance Date	Apr 2, 2019
Publication Date	Apr 6, 2019
Deposit Date	May 31, 2019
Publicly Available Date	May 31, 2019
Journal	Materials
Print ISSN	1996-1944
Electronic ISSN	1996-1944
Publisher	MDPI
Peer Reviewed	Peer Reviewed
Volume	12
Issue	7
Pages	1126
DOI	https://doi.org/10.3390/ma12071126
Keywords	biosensor; impedance; ZnO–CuO; CRP
Public URL	https://uwe-repository.worktribe.com/output/849023
Publisher URL	https://doi.org/10.3390/ma12071126
Contract Date	May 31, 2019