Outputs (1695)

Fenofibrate toxicity and impact on clinical biomarkers in patients with dyslipidaemia (2020)
Thesis

Introduction and aims: Fenofibrate is the most widely used fibric acid derivative for managing mixed dyslipidaemia, characterised by elevated levels of cholesterol, triglycerides and LDL cholesterol and low levels of HDL cholesterol. Fenofibrate is a... Read More about Fenofibrate toxicity and impact on clinical biomarkers in patients with dyslipidaemia.

Rapid bactericidal effect of cinnamon bark essential oil against Pseudomonas aeruginosa (2019)
Journal Article

AIMS: This study aimed to identify the most effective antimicrobial from a selection of essential oils and investigate its bactericidal properties against Ps. aeruginosa. METHODS AND RESULTS: The disc diffusion assay and minimal inhibitory/bacte... Read More about Rapid bactericidal effect of cinnamon bark essential oil against Pseudomonas aeruginosa.

In vitro antimicrobial activity of Cymbopogon flexuosus against Staphylococcus aureus and Acinetobacter baumannii (2018)
Presentation / Conference Contribution

Staphylococcus aureus (S. aureus) and Acinetobacter baumannii (A. baumannii) are both significant nosocomial pathogens that have become increasingly resistant to conventional antimicrobial therapies. There is a need for alternative therapies to com... Read More about In vitro antimicrobial activity of Cymbopogon flexuosus against Staphylococcus aureus and Acinetobacter baumannii.

Antimicrobial activity of cinnamon essential oil and its effect against P.aeruginosa biofilms (2018)
Presentation / Conference Contribution

Evaluation of antifungal activities and antihaemolytic effects of cinnamon essential oils from leaf and bark on Candida albicans and Candida auris (2019)
Presentation / Conference Contribution

Candida infections can be considered as a significant source of patient morbidity and mortality. Candida albicans is the most common pathogen causing Candida infections. Candida auris is a newly described pathogen that is associated with multi-drug r... Read More about Evaluation of antifungal activities and antihaemolytic effects of cinnamon essential oils from leaf and bark on Candida albicans and Candida auris.

Evaluation of additives on reversed-phase chromatography of monoclonal antibodies using a 1000 Å stationary phase (2019)
Journal Article

© 2019 Elsevier B.V. A wide pore (1000 Å) diphenyl stationary phase was evaluated for the analysis of monoclonal antibodies (mAbs), comparing a conventional mobile phase of acetonitrile-water containing overall 0.1% trifluoracetic acid (TFA) with a s... Read More about Evaluation of additives on reversed-phase chromatography of monoclonal antibodies using a 1000 Å stationary phase.

A systematic approach to understand hydrogeochemical dynamics in large river systems: Development and application to the River Ganges (Ganga) in India (2022)
Journal Article

Large river systems, such as the River Ganges (Ganga), provide crucial water resources for the environment and society, yet often face significant challenges associated with cumulative impacts arising from upstream environmental and anthropogenic inf... Read More about A systematic approach to understand hydrogeochemical dynamics in large river systems: Development and application to the River Ganges (Ganga) in India.

The role of hBCATc in breast cancer progression through IGF-1 and insulin signalling cascades (2020)
Thesis

Introduction and Aims: Breast cancer remains the leading cause of cancer mortality in women globally, despite advances in the development of targeted therapies. Driven by oncogenic signals, cancer cells undergo metabolic reprogramming, upregulatin... Read More about The role of hBCATc in breast cancer progression through IGF-1 and insulin signalling cascades.

Inhibition of corrosion causing Pseudomonas aeruginosa using plasma-activated water (2021)
Journal Article

Aims: The cost of Microbiologically Influenced Corrosion (MIC) significantly affects a wide range of sectors. This study aims to assess the efficiency of a novel technology based on the use of plasma-activated water (PAW) in inhibiting corrosion caus... Read More about Inhibition of corrosion causing Pseudomonas aeruginosa using plasma-activated water.

Novel, rapid, low-cost screen-printed (bio)sensors for the direct analysis of boar taint compounds androstenone and skatole in porcine adipose tissue: Comparison with a high-resolution gas chromatographic method (2019)
Journal Article

© 2019 Elsevier B.V. This is the first report on the fabrication, characterisation and application of an electrochemical (bio)sensor system for the simultaneous measurement of skatole and androstenone. A biosensor for androstenone was fabricated usin... Read More about Novel, rapid, low-cost screen-printed (bio)sensors for the direct analysis of boar taint compounds androstenone and skatole in porcine adipose tissue: Comparison with a high-resolution gas chromatographic method.

Influence of Bone Marrow Stromal and Leukemic Cells on Cytarabine Chemo-Toxicity in Acute Myeloid Leukemia (AML). (2019)
Presentation / Conference Contribution

Mesenchymal stromal cells (MSC) are known to protect leukemic cells from drug-induced toxicity within the bone marrow (BM) niche, however, less is known about leukemic impact on supportive MSC. The nucleoside-analogue, cytarabine (Ara-C), is a front-... Read More about Influence of Bone Marrow Stromal and Leukemic Cells on Cytarabine Chemo-Toxicity in Acute Myeloid Leukemia (AML)..

Leukaemic and bone marrow stromal cells alter cytarabine genotoxicity and cytotoxicity in favour of disease (2019)
Presentation / Conference Contribution

Resistance to therapy remains one of the greatest challenges in the management of the blood and bone marrow (BM) disorder, acute myeloid leukaemia (AML). This study aimed to investigate how leukaemic and BM stromal cells contribute to altered chemo-s... Read More about Leukaemic and bone marrow stromal cells alter cytarabine genotoxicity and cytotoxicity in favour of disease.

Cytotoxicity and genotoxicity of electrochemically activated solutions (ECAS) (2017)
Presentation / Conference Contribution

Electrochemically activated solutions (ECAS) are of interest as potential disinfectants due to high biocidal activity against many microorganisms. They are widely used clinically in some countries (decontamination of surgical instruments and wounds),... Read More about Cytotoxicity and genotoxicity of electrochemically activated solutions (ECAS).

Development of a 2D leukaemia-stroma model for analyses of chemo-toxicity protection using a novel bacterial bioluminescent biosensor (2017)
Presentation / Conference Contribution

This study aimed to develop a 2D leukaemia-stroma model of the bone marrow for analysis of stromal-mediated chemo-protection; known to contribute to chemotherapy resistance. The model must facilitate integration of a bioluminescent biosensor HA1 for... Read More about Development of a 2D leukaemia-stroma model for analyses of chemo-toxicity protection using a novel bacterial bioluminescent biosensor.

Rapid in vitro testing and characterization of resistance to chemotherapeutic agents daunorubicin and cytarabine in acute myeloid leukaemia (2017)
Presentation / Conference Contribution

Treatment success in leukaemia is impacted by patient resistance to chemotherapy including cytarabine (ara-C) and the anthracycline daunorubicin (DNR) requiring rapid pre-screening testing. DNR is converted to daunorubicinol (DNRol) by carbonyl reduc... Read More about Rapid in vitro testing and characterization of resistance to chemotherapeutic agents daunorubicin and cytarabine in acute myeloid leukaemia.

ICI-RS 2019 nocturia think tank: How can experimental science guide us in understanding the pathophysiology of nocturia? (2020)
Journal Article

Introduction: The following is a report on the proceedings of the 2019 International Consultation on Incontinence-Research Society nocturia think tank (NTT). Objectives: The objectives of the 2019 NTT were as follows: (a) to evaluate the role of urot... Read More about ICI-RS 2019 nocturia think tank: How can experimental science guide us in understanding the pathophysiology of nocturia?.

The use of storm fragments and biodegradable replanting methods allows for a low-impact habitat restoration method of seagrass meadows, in the eastern Aegean Sea (2020)
Journal Article

Seagrasses are important marine ecosystems but are vulnerable to physical damage from anthropogenic activities such as anchoring and trawling. Replanting damaged areas can represent a viable restoration strategy, yet current methods rely on the remov... Read More about The use of storm fragments and biodegradable replanting methods allows for a low-impact habitat restoration method of seagrass meadows, in the eastern Aegean Sea.

Advantages and limitations of naturalistic study designs and their implementation in alcohol hangover research (2019)
Journal Article

In alcohol hangover research, both naturalistic designs and randomized controlled trials (RCTs) are successfully employed to study the causes, consequences, and treatments of hangovers. Although increasingly applied in both social sciences and medica... Read More about Advantages and limitations of naturalistic study designs and their implementation in alcohol hangover research.

Relationship between alcohol hangover and physical endurance performance: Walking the Samaria Gorge (2019)
Journal Article

Alcohol hangover is a potentially debilitating state. Several studies have demonstrated that it does not seem to impair strength or short-term endurance, but its effects on continuous exercise performance/long-term endurance have never been investiga... Read More about Relationship between alcohol hangover and physical endurance performance: Walking the Samaria Gorge.

Sensitivity to experiencing alcohol hangovers: Reconsideration of the 0.11% blood alcohol concentration (BAC) threshold for having a hangover (2020)
Journal Article

The 2010 Alcohol Hangover Research Group consensus paper defined a cutoff blood alcohol concentration (BAC) of 0.11% as a toxicological threshold indicating that sufficient alcohol had been consumed to develop a hangover. The cutoff was based on prev... Read More about Sensitivity to experiencing alcohol hangovers: Reconsideration of the 0.11% blood alcohol concentration (BAC) threshold for having a hangover.