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Rapid bactericidal effect of cinnamon bark essential oil against Pseudomonas aeruginosa

Elcocks, Ellena; Spencer‐Phillips, Peter; Adukwu, Emmanuel

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Authors

Ellena Elcocks



Abstract

AIMS:
This study aimed to identify the most effective antimicrobial from a selection of essential oils and investigate its bactericidal properties against Ps. aeruginosa.

METHODS AND RESULTS:
The disc diffusion assay and minimal inhibitory/bactericidal concentration tests were used to identify antimicrobial potential. Several oils exhibited antimicrobial effects at concentrations as low as 0·03% (v/v). Significantly, cinnamon (Cinnamomum zeylanicum) bark oil exhibited broad spectrum activity against Gram-negative and Gram-positive bacteria and showed bacteriostatic and bactericidal effects against Ps. aeruginosa PAO1 at 0·125% (v/v) and all other tested organisms, including known multidrug resistant species. Time-kill assays and metabolic activity tests showed cinnamon oil to exhibit rapid killing, with bactericidal activity observed in ≤ 6 min at ≥ 0·5% (v/v). Furthermore, scanning electron microscopy and a membrane permeability assay indicated damage to membrane integrity, loss of turgor and cell collapse.

CONCLUSION:
Cinnamon bark essential oil is a broad-spectrum antimicrobial capable of rapid killing at low concentrations.

SIGNIFICANCE AND IMPACT OF STUDY:
This study provides a sound basis for further investigation of the potential of cinnamon bark essential oil as an alternative to conventional antimicrobial products due to its fast acting bactericidal properties at low concentrations.

Citation

Elcocks, E., Spencer‐Phillips, P., & Adukwu, E. (2020). Rapid bactericidal effect of cinnamon bark essential oil against Pseudomonas aeruginosa. Journal of Applied Microbiology, 128(4), 1025-1037. https://doi.org/10.1111/jam.14538

Journal Article Type Article
Acceptance Date Nov 28, 2019
Online Publication Date Dec 17, 2019
Publication Date Apr 1, 2020
Deposit Date Dec 17, 2019
Publicly Available Date Dec 18, 2020
Journal Journal of Applied Microbiology
Print ISSN 1364-5072
Electronic ISSN 1365-2672
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 128
Issue 4
Pages 1025-1037
DOI https://doi.org/10.1111/jam.14538
Keywords Biotechnology; Applied Microbiology and Biotechnology; General Medicine
Public URL https://uwe-repository.worktribe.com/output/4773669

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Copyright Statement
This is the peer reviewed version of the article, which has been published in final form at https://doi.org/10.1111/jam.14538. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.







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