Outputs (132)

Frequency-dependent characteristics of nerve-mediated ATP and acetylcholine release from detrusor smooth muscle (2022)
Journal Article

New Findings: What is the central question of this study? Is the frequency dependence of co-transmitter release from postganglionic nerve fibres different for each transmitter? What is the main finding and its importance? Release of co-transmitters f... Read More about Frequency-dependent characteristics of nerve-mediated ATP and acetylcholine release from detrusor smooth muscle.

A novel, scalable social media-based intervention Warna-Warni Waktu to reduce body dissatisfaction among young Indonesian women: Protocol for a parallel randomized controlled trial (2022)
Journal Article

Background: Despite the prevalence of body dissatisfaction among young Indonesian women and its consequential negative impacts, there are currently no evidence-based, culturally appropriate interventions to tackle this issue. Therefore, there is a ne... Read More about A novel, scalable social media-based intervention Warna-Warni Waktu to reduce body dissatisfaction among young Indonesian women: Protocol for a parallel randomized controlled trial.

Insights into the dynamics of ligand-induced dimerisation via mathematical modelling and analysis (2022)
Journal Article

The vascular endothelial growth factor (VEGF) receptor (VEGFR) system plays a role in cancer and many other diseases. It is widely accepted that VEGFR receptors dimerise in response to VEGF binding. However, analysis of these mechanisms and their imp... Read More about Insights into the dynamics of ligand-induced dimerisation via mathematical modelling and analysis.

An acceptance and commitment therapy prototype mobile program for individuals with a visible difference: Mixed methods feasibility study (2022)
Journal Article

Background: Mobile apps may offer a valuable platform for delivering evidence-based psychological interventions for individuals with atypical appearances, or visible differences, who experience psychosocial appearance concerns such as appearance-base... Read More about An acceptance and commitment therapy prototype mobile program for individuals with a visible difference: Mixed methods feasibility study.

‘Dove Confident Me Indonesia: Single Session’: Study protocol for a randomised controlled trial to evaluate a school-based body image intervention among Indonesian adolescents (2021)
Journal Article

Background: Due to the prevalence and associated adverse health consequences of negative body image among adolescents globally, there is a need to develop acceptable, effective, and scalable interventions. School-based body image interventions delive... Read More about ‘Dove Confident Me Indonesia: Single Session’: Study protocol for a randomised controlled trial to evaluate a school-based body image intervention among Indonesian adolescents.

Testing the responsiveness of and defining MID (minimal important difference) values for the CARe Burn Scales: Patient-reported outcome measures (PROMs) to assess quality of life for children and young people affected by burn injuries, and their parents/caregivers (2021)
Journal Article

Background: The CARe Burn Scales are a portfolio of burn-specific PROMs for people affected by burns, including a Child Form (for children < 8 years (Parent-proxy)), a Young Person Form (for young people aged 8 -17 years), an Adult Form, and a Parent... Read More about Testing the responsiveness of and defining MID (minimal important difference) values for the CARe Burn Scales: Patient-reported outcome measures (PROMs) to assess quality of life for children and young people affected by burn injuries, and their parents/caregivers.

Neurocognitive function following out-of-hospital cardiac arrest: A systematic review (2021)
Journal Article

Objectives: The primary aim of this review was to investigate neurocognitive outcomes following out-of-hospital cardiac arrest (OHCA). Specifically, the focus was on identifying the different neurocognitive domains that are assessed, the measures use... Read More about Neurocognitive function following out-of-hospital cardiac arrest: A systematic review.

Estimation of the two-group pilot sample size with a cautionary note on Browne’s formula (2021)
Journal Article

Using data obtained from a pilot study, Browne (1995) proposed a procedure for estimating the sample size needed for a definitive two-arm randomised controlled trial when the minimal important difference is specified. Simulations confirm these findi... Read More about Estimation of the two-group pilot sample size with a cautionary note on Browne’s formula.

Ordinal Logistic Regression as an alternative analysis strategy for the comparison of two independent samples (2021)
Journal Article

The two group between subjects design is pervasive with analyses often performed using the Mann Whitney Rank Sum test or using the Welch variant of the t-test. Using simulation it is shown that a dummy variable ordinal logistic regression (OLR) mode... Read More about Ordinal Logistic Regression as an alternative analysis strategy for the comparison of two independent samples.

Students’ perceptions of enhanced e-assessment feedback addressing common student errors in mathematics (2021)
Journal Article

The Common Student Errors Project (CSE Project) has been running at the University of the West of England (UWE, Bristol) since 2017. The main aim of this project is to introduce a method to detect CSEs and to provide tailored feedback in Engineering... Read More about Students’ perceptions of enhanced e-assessment feedback addressing common student errors in mathematics.

Protocol for a national cohort study to explore the long-term clinical and patient-reported outcomes and cost-effectiveness of implant-based and autologous breast reconstruction after mastectomy for breast cancer: The Brighter Study (2021)
Journal Article

Introduction Breast reconstruction (BR) is offered to improve quality of life for women with breast cancer undergoing mastectomy. As most women will be long-Term breast cancer survivors, high-quality information regarding the long-Term outcomes of di... Read More about Protocol for a national cohort study to explore the long-term clinical and patient-reported outcomes and cost-effectiveness of implant-based and autologous breast reconstruction after mastectomy for breast cancer: The Brighter Study.

Patient reported psychosocial functioning following successful ptosis surgery (2021)
Journal Article

Background: Ptosis may result in increased anxiety, appearance-related distress and social avoidance, and impacts visual function. Previous work demonstrates the benefits of ptosis surgery for health-related quality of life, but there is a paucity of... Read More about Patient reported psychosocial functioning following successful ptosis surgery.

Ambulatory management of secondary spontaneous pneumothorax: A randomised controlled trial (2021)
Journal Article

Secondary spontaneous pneumothorax (SSP) is traditionally managed with an intercostal chest tube attached to an underwater seal. We investigated whether use of a one-way flutter valve shortened patients' length of stay (LoS). This open-label randomis... Read More about Ambulatory management of secondary spontaneous pneumothorax: A randomised controlled trial.

“They were aware of who I was as a person”: Patients’ and health professionals’ experiences of using the PEGASUS intervention to facilitate decision-making around breast reconstruction (2021)
Journal Article

Objective: Many women choose to have breast reconstruction after mastectomy, however, decision-making can be difficult and expectations are often unmet. The PEGASUS intervention (Patient Expectations and Goals: Assisting Shared Understanding of Surge... Read More about “They were aware of who I was as a person”: Patients’ and health professionals’ experiences of using the PEGASUS intervention to facilitate decision-making around breast reconstruction.

Protocol for a mixed-method study to inform the feasibility of undertaking a large-scale multicentre study comparing the clinical and patient-reported outcomes of oncoplastic breast conservation as an alternative to mastectomy with or without immediate breast reconstruction in women unsuitable for standard breast-conserving surgery (the ANTHEM Feasibility Study) (2021)
Journal Article

Introduction: Approximately 40% of the 55,000 women diagnosed with breast cancer each year in the UK undergo mastectomy because they are considered unsuitable for standard breast conserving surgery (BCS) due to tumour size or multiple tumour foci. Ma... Read More about Protocol for a mixed-method study to inform the feasibility of undertaking a large-scale multicentre study comparing the clinical and patient-reported outcomes of oncoplastic breast conservation as an alternative to mastectomy with or without immediate breast reconstruction in women unsuitable for standard breast-conserving surgery (the ANTHEM Feasibility Study).

2008 financial crisis versus 2020 economic fallout: How COVID-19 might influence fertility treatment and live births (2021)
Journal Article

Research question
The economic and reproductive medicine response to the coronavirus disease 2019 (COVID-19) pandemic in the USA has reduced the affordability and accessibility of fertility care. What is the impact of the 2008 financial recession an... Read More about 2008 financial crisis versus 2020 economic fallout: How COVID-19 might influence fertility treatment and live births.

A case study in the e-assessment of statistics for non-specialists (2021)
Journal Article

The need to be able to choose, perform and interpret the results from appropriate statistical tests is ubiquitous in many STEM disciplines and beyond. In this case study, we illustrate a learning and assessment approach that has been used successfull... Read More about A case study in the e-assessment of statistics for non-specialists.

Advanced molecular characterization using Digital Spatial Profiling Technology on immuno-oncology targets in methylated compared with unmethylated IDH-wildtype glioblastoma (2021)
Journal Article

Introduction. Glioblastoma (GBM) is the most common primary adult brain tumour with a median overall survival (OS) of 12-15 months. Molecular characterization of multiple immunooncology targets in GBM may help target novel immunotherapeutic strategie... Read More about Advanced molecular characterization using Digital Spatial Profiling Technology on immuno-oncology targets in methylated compared with unmethylated IDH-wildtype glioblastoma.

Fixed bearing, all-polyethylene tibia, lateral unicompartmental arthroplasty – A final outcome study with up to 28 year follow-up of a single implant (2021)
Journal Article

Background: Lateral unicompartmental arthroplasty (UKA) constitutes only 5–10% of all unicompartmental replacements performed. Whilst the short and medium term benefits are well documented, there remains concern regarding the higher revision rate whe... Read More about Fixed bearing, all-polyethylene tibia, lateral unicompartmental arthroplasty – A final outcome study with up to 28 year follow-up of a single implant.

A single arm phase II trial of neoadjuvant cabazitaxel and cisplatin chemotherapy for muscle invasive transitional cell carcinoma of the urinary bladder (2021)
Journal Article

Introduction: Neoadjuvant cisplatin-based combination chemotherapy improves survival in muscle-invasive bladder cancer. However, response rates and survival remain suboptimal. We evaluated the efficacy, safety, and tolerability of cisplatin plus caba... Read More about A single arm phase II trial of neoadjuvant cabazitaxel and cisplatin chemotherapy for muscle invasive transitional cell carcinoma of the urinary bladder.