Outputs (124)

Ordinal Logistic Regression as an alternative analysis strategy for the comparison of two independent samples (2021)
Journal Article

The two group between subjects design is pervasive with analyses often performed using the Mann Whitney Rank Sum test or using the Welch variant of the t-test. Using simulation it is shown that a dummy variable ordinal logistic regression (OLR) mode... Read More about Ordinal Logistic Regression as an alternative analysis strategy for the comparison of two independent samples.

Students’ perceptions of enhanced e-assessment feedback addressing common student errors in mathematics (2021)
Journal Article

The Common Student Errors Project (CSE Project) has been running at the University of the West of England (UWE, Bristol) since 2017. The main aim of this project is to introduce a method to detect CSEs and to provide tailored feedback in Engineering... Read More about Students’ perceptions of enhanced e-assessment feedback addressing common student errors in mathematics.

Protocol for a national cohort study to explore the long-term clinical and patient-reported outcomes and cost-effectiveness of implant-based and autologous breast reconstruction after mastectomy for breast cancer: The Brighter Study (2021)
Journal Article

Introduction Breast reconstruction (BR) is offered to improve quality of life for women with breast cancer undergoing mastectomy. As most women will be long-Term breast cancer survivors, high-quality information regarding the long-Term outcomes of di... Read More about Protocol for a national cohort study to explore the long-term clinical and patient-reported outcomes and cost-effectiveness of implant-based and autologous breast reconstruction after mastectomy for breast cancer: The Brighter Study.

Patient reported psychosocial functioning following successful ptosis surgery (2021)
Journal Article

Background: Ptosis may result in increased anxiety, appearance-related distress and social avoidance, and impacts visual function. Previous work demonstrates the benefits of ptosis surgery for health-related quality of life, but there is a paucity of... Read More about Patient reported psychosocial functioning following successful ptosis surgery.

Ambulatory management of secondary spontaneous pneumothorax: A randomised controlled trial (2021)
Journal Article

Secondary spontaneous pneumothorax (SSP) is traditionally managed with an intercostal chest tube attached to an underwater seal. We investigated whether use of a one-way flutter valve shortened patients' length of stay (LoS). This open-label randomis... Read More about Ambulatory management of secondary spontaneous pneumothorax: A randomised controlled trial.

“They were aware of who I was as a person”: Patients’ and health professionals’ experiences of using the PEGASUS intervention to facilitate decision-making around breast reconstruction (2021)
Journal Article

Objective: Many women choose to have breast reconstruction after mastectomy, however, decision-making can be difficult and expectations are often unmet. The PEGASUS intervention (Patient Expectations and Goals: Assisting Shared Understanding of Surge... Read More about “They were aware of who I was as a person”: Patients’ and health professionals’ experiences of using the PEGASUS intervention to facilitate decision-making around breast reconstruction.

Protocol for a mixed-method study to inform the feasibility of undertaking a large-scale multicentre study comparing the clinical and patient-reported outcomes of oncoplastic breast conservation as an alternative to mastectomy with or without immediate breast reconstruction in women unsuitable for standard breast-conserving surgery (the ANTHEM Feasibility Study) (2021)
Journal Article

Introduction: Approximately 40% of the 55,000 women diagnosed with breast cancer each year in the UK undergo mastectomy because they are considered unsuitable for standard breast conserving surgery (BCS) due to tumour size or multiple tumour foci. Ma... Read More about Protocol for a mixed-method study to inform the feasibility of undertaking a large-scale multicentre study comparing the clinical and patient-reported outcomes of oncoplastic breast conservation as an alternative to mastectomy with or without immediate breast reconstruction in women unsuitable for standard breast-conserving surgery (the ANTHEM Feasibility Study).

2008 financial crisis versus 2020 economic fallout: How COVID-19 might influence fertility treatment and live births (2021)
Journal Article

Research question
The economic and reproductive medicine response to the coronavirus disease 2019 (COVID-19) pandemic in the USA has reduced the affordability and accessibility of fertility care. What is the impact of the 2008 financial recession an... Read More about 2008 financial crisis versus 2020 economic fallout: How COVID-19 might influence fertility treatment and live births.

A case study in the e-assessment of statistics for non-specialists (2021)
Journal Article

The need to be able to choose, perform and interpret the results from appropriate statistical tests is ubiquitous in many STEM disciplines and beyond. In this case study, we illustrate a learning and assessment approach that has been used successfull... Read More about A case study in the e-assessment of statistics for non-specialists.

Advanced molecular characterization using Digital Spatial Profiling Technology on immuno-oncology targets in methylated compared with unmethylated IDH-wildtype glioblastoma (2021)
Journal Article

Introduction. Glioblastoma (GBM) is the most common primary adult brain tumour with a median overall survival (OS) of 12-15 months. Molecular characterization of multiple immunooncology targets in GBM may help target novel immunotherapeutic strategie... Read More about Advanced molecular characterization using Digital Spatial Profiling Technology on immuno-oncology targets in methylated compared with unmethylated IDH-wildtype glioblastoma.

Fixed bearing, all-polyethylene tibia, lateral unicompartmental arthroplasty – A final outcome study with up to 28 year follow-up of a single implant (2021)
Journal Article

Background: Lateral unicompartmental arthroplasty (UKA) constitutes only 5–10% of all unicompartmental replacements performed. Whilst the short and medium term benefits are well documented, there remains concern regarding the higher revision rate whe... Read More about Fixed bearing, all-polyethylene tibia, lateral unicompartmental arthroplasty – A final outcome study with up to 28 year follow-up of a single implant.

A single arm phase II trial of neoadjuvant cabazitaxel and cisplatin chemotherapy for muscle invasive transitional cell carcinoma of the urinary bladder (2021)
Journal Article

Introduction: Neoadjuvant cisplatin-based combination chemotherapy improves survival in muscle-invasive bladder cancer. However, response rates and survival remain suboptimal. We evaluated the efficacy, safety, and tolerability of cisplatin plus caba... Read More about A single arm phase II trial of neoadjuvant cabazitaxel and cisplatin chemotherapy for muscle invasive transitional cell carcinoma of the urinary bladder.

St Georg Sled medial unicompartmental arthroplasty: survivorship analysis and function at 20years follow up (2021)
Journal Article

Purpose: The peri-operative and short-term benefits of unicompartmental knee arthroplasty (UKA) are well supported in the literature. However, there remains concern regarding the higher revision rate when compared with total knee replacement. This ma... Read More about St Georg Sled medial unicompartmental arthroplasty: survivorship analysis and function at 20years follow up.

Differential expression of the BCAT isoforms between breast cancer subtypes (2020)
Journal Article

© 2020, The Author(s). Background: Biological characterisation of breast cancer subtypes is essential as it informs treatment regimens especially as different subtypes have distinct locoregional patterns. This is related to metabolic phenotype, where... Read More about Differential expression of the BCAT isoforms between breast cancer subtypes.

Challenges and reflections from a multi-centre trial of a psycho-oncology intervention to support shared decision-making in breast reconstruction (2020)
Journal Article

‘Everybody’s Different: The Appearance Game’. A randomised controlled trial evaluating an appearance-related board game intervention with children aged 9-11 years (2020)
Journal Article

This study evaluated the effectiveness of an educational board game aimed at increasing knowledge of appearance-related issues, positive body image, media literacy, and acceptance of appearance diversity with British school children. Two hundred and... Read More about ‘Everybody’s Different: The Appearance Game’. A randomised controlled trial evaluating an appearance-related board game intervention with children aged 9-11 years.

A structured approach to evaluating life course hypotheses: Moving beyond analyses of exposed versus unexposed in the omics context (2020)
Journal Article

The structured life course modeling approach (SLCMA) is a theory-driven analytic method that empirically compares multiple prespecified life course hypotheses characterizing time-dependent exposure-outcome relationships to determine which theory best... Read More about A structured approach to evaluating life course hypotheses: Moving beyond analyses of exposed versus unexposed in the omics context.

Exposure to early childhood maltreatment and its effect over time on social cognition (2020)
Journal Article

Social cognitive deficits can have many negative consequences, spanning social withdrawal to psychopathology. Prior work has shown that child maltreatment may associate with poorer social cognitive skills in later life. However, no studies have exami... Read More about Exposure to early childhood maltreatment and its effect over time on social cognition.

Daily medical liaison is associated with reduced length of stay and complications in selected patients admitted to a regional vascular surgery service (2020)
Journal Article

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Older adults undergoing vascular surgery are particularly vulnerable to adverse outcomes by virtue of their vascular risk factors and medical comorbidities. This study aimed to determine the i... Read More about Daily medical liaison is associated with reduced length of stay and complications in selected patients admitted to a regional vascular surgery service.

Exact solutions and equi-dosing regimen regions for multi-dose pharmacokinetics models with transit compartments (2020)
Journal Article

Compartmental models which yield linear ordinary differential equations (ODEs) provide common tools for pharmacokinetics (PK) analysis, with exact solutions for drug levels or concentrations readily obtainable for low-dimensional compartment models.... Read More about Exact solutions and equi-dosing regimen regions for multi-dose pharmacokinetics models with transit compartments.