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Outputs (157)

Patient-reported outcomes 3 and 18 months after mastectomy and immediate prepectoral implant-based breast reconstruction in the UK Pre-BRA prospective multicentre cohort study (2025)
Journal Article

Introduction Prepectoral techniques are becoming standard of care for implant-based breast reconstruction due to reduced impact on chest wall function and improved patient satisfaction. Evidence to support these benefits, however, is lacking. Here, p... Read More about Patient-reported outcomes 3 and 18 months after mastectomy and immediate prepectoral implant-based breast reconstruction in the UK Pre-BRA prospective multicentre cohort study.

Exploring the ethical challenges of large language models in emergency medicine: A comparative international review (2025)
Presentation / Conference Contribution

Large Language Models (LLMs) hold promise for advancing Emergency Medicine by enhancing operational efficiency and supporting decision-making. This scoping review explores the ethical, legal, and global considerations influencing LLM deployment in em... Read More about Exploring the ethical challenges of large language models in emergency medicine: A comparative international review.

Clinical and patient-reported outcomes in women offered oncoplastic breast conserving surgery as an alternative to mastectomy in the ANTHEM multicentre, prospective cohort study (2024)
Journal Article

ABSTRACT

Background: Oncoplastic breast conserving surgery (OPBCS) may be a better option than mastectomy, but high-quality comparative evidence is lacking. The ANTHEM study (ISRCTN18238549) aimed to explore clinical and patient-reported outcomes... Read More about Clinical and patient-reported outcomes in women offered oncoplastic breast conserving surgery as an alternative to mastectomy in the ANTHEM multicentre, prospective cohort study.

Does intermittent nutrition enterally normalise hormonal and metabolic responses to feeding in critically ill adults? A protocol for the dine-normal proof-of-concept randomised parallel group study (2024)
Journal Article

Introduction
Over half of patients who spend >48 hours in the intensive care unit (ICU) are fed via a nasogastric (NG) tube. Current guidance recommends continuous delivery of feed throughout the day and night. Emerging evidence from healthy human s... Read More about Does intermittent nutrition enterally normalise hormonal and metabolic responses to feeding in critically ill adults? A protocol for the dine-normal proof-of-concept randomised parallel group study.

Understanding women’s decision making for and against oncoplastic breast conserving surgery as an alternative to mastectomy in early breast cancer: UK ANTHEM qualitative study (2024)
Journal Article

ABSTRACT

Background: Oncoplastic breast conserving surgery (OPBCS) may allow women with early breast cancer to avoid mastectomy, but many women choose more extensive surgery even when breast conserving options are offered. Reasons for this are un... Read More about Understanding women’s decision making for and against oncoplastic breast conserving surgery as an alternative to mastectomy in early breast cancer: UK ANTHEM qualitative study.

Depressive symptoms in adolescence and adult educational and employment outcomes: A structured life course analysis (2024)
Journal Article

Background. Depression is a common mental health disorder that often starts during adolescence, with potentially important future consequences including ‘Not in Education, Employment or Training’ (NEET) status. Methods. We took a structured life cour... Read More about Depressive symptoms in adolescence and adult educational and employment outcomes: A structured life course analysis.

Developing emotional preparedness and mental resilience through high-fidelity simulation: A ‘bridge too far’ for institutions teaching major trauma management and mass-casualty medicine? (2024)
Journal Article

Background: Clinical acumen represents only part of being adequately equipped to attend a major incident. The emotive sights, sounds and smells of these dynamic environments are all-encompassing experiences, and responders must also be armed with the... Read More about Developing emotional preparedness and mental resilience through high-fidelity simulation: A ‘bridge too far’ for institutions teaching major trauma management and mass-casualty medicine?.

How well do parents identify their child's baby teeth? Engagement and accuracy of parent-reported information on a tooth checklist survey (2024)
Journal Article

Objectives: Naturally exfoliated primary teeth are being increasingly collected in child development studies. Most of these odontological collections and tooth biobanks use parent-reported information from questionnaires or tooth checklists to collec... Read More about How well do parents identify their child's baby teeth? Engagement and accuracy of parent-reported information on a tooth checklist survey.

The relationship between type, timing and duration of exposure to adverse childhood experiences and adolescent self-harm and depression: Findings from three UK prospective population-based cohorts (2024)
Journal Article

Background: Adverse childhood experiences (ACEs) are well-established risk factors for self-harm and depression. However, despite their high comorbidity, there has been little focus on the impact of developmental timing and the duration of exposure t... Read More about The relationship between type, timing and duration of exposure to adverse childhood experiences and adolescent self-harm and depression: Findings from three UK prospective population-based cohorts.

Computational modelling of dynamic cAMP responses to GPCR agonists for exploration of GLP-1R ligand effects in pancreatic β-cells and neurons (2024)
Journal Article

The glucagon-like peptide-1 receptor (GLP-1R) is a class B G protein-coupled receptor (GPCR) which plays important physiological roles in insulin release and promoting fullness. GLP-1R agonists initiate cellular responses by cyclic AMP (cAMP) pathway... Read More about Computational modelling of dynamic cAMP responses to GPCR agonists for exploration of GLP-1R ligand effects in pancreatic β-cells and neurons.