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Outputs (161)

Inter-rater reliability of stress signatures in exfoliated primary dentition - Improving scientific rigor and reproducibility in histological data collection (2025)
Journal Article

Accentuated Lines (ALs) in tooth enamel can reflect metabolic disruptions from physiological or psychological stresses during development. They can therefore serve as a retrospective biomarker of generalized stress exposure in archaeological and clin... Read More about Inter-rater reliability of stress signatures in exfoliated primary dentition - Improving scientific rigor and reproducibility in histological data collection.

Defining the recommended gray zone in MGMT promoter methylation pyrosequencing reporting: A robust translatable method to implement new EANO guidelines (2025)
Journal Article

Abstract

Background: The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) may cause resistance of tumour cells to alkylating agents, and is a predictive biomarker in high-grade gliomas treated with temozolomide. Recent EANO guideli... Read More about Defining the recommended gray zone in MGMT promoter methylation pyrosequencing reporting: A robust translatable method to implement new EANO guidelines.

Sensitive periods for exposure to indoor air pollutants and psychosocial factors in association with symptoms of psychopathology at school-age in a South African birth cohort (2025)
Journal Article

Exposure to environmental toxicants and psychosocial stressors during gestation and early life are particularly harmful and may impact brain development. Specifically, exposure to indoor air pollutants (IAP) and psychosocial factors (PF) during these... Read More about Sensitive periods for exposure to indoor air pollutants and psychosocial factors in association with symptoms of psychopathology at school-age in a South African birth cohort.

Patient-reported outcomes 3 and 18 months after mastectomy and immediate prepectoral implant-based breast reconstruction in the UK Pre-BRA prospective multicentre cohort study (2025)
Journal Article

Introduction Prepectoral techniques are becoming standard of care for implant-based breast reconstruction due to reduced impact on chest wall function and improved patient satisfaction. Evidence to support these benefits, however, is lacking. Here, p... Read More about Patient-reported outcomes 3 and 18 months after mastectomy and immediate prepectoral implant-based breast reconstruction in the UK Pre-BRA prospective multicentre cohort study.

"My body is amazing from the bottom to the top" - An RCT study testing two positive body image media micro-interventions for young children aged 4-6 years (2025)
Journal Article

This study presents a fully powered RCT testing the effectiveness and acceptability of two positive body image online media-based micro-interventions designed for young children. A total of 439 children aged 4-6 years were randomised into one of four... Read More about "My body is amazing from the bottom to the top" - An RCT study testing two positive body image media micro-interventions for young children aged 4-6 years.

Exploring the ethical challenges of large language models in emergency medicine: A comparative international review (2025)
Presentation / Conference Contribution

Large Language Models (LLMs) hold promise for advancing Emergency Medicine by enhancing operational efficiency and supporting decision-making. This scoping review explores the ethical, legal, and global considerations influencing LLM deployment in em... Read More about Exploring the ethical challenges of large language models in emergency medicine: A comparative international review.

Clinical and patient-reported outcomes in women offered oncoplastic breast conserving surgery as an alternative to mastectomy in the ANTHEM multicentre, prospective cohort study (2024)
Journal Article

ABSTRACT

Background: Oncoplastic breast conserving surgery (OPBCS) may be a better option than mastectomy, but high-quality comparative evidence is lacking. The ANTHEM study (ISRCTN18238549) aimed to explore clinical and patient-reported outcomes... Read More about Clinical and patient-reported outcomes in women offered oncoplastic breast conserving surgery as an alternative to mastectomy in the ANTHEM multicentre, prospective cohort study.

Does intermittent nutrition enterally normalise hormonal and metabolic responses to feeding in critically ill adults? A protocol for the dine-normal proof-of-concept randomised parallel group study (2024)
Journal Article

Introduction
Over half of patients who spend >48 hours in the intensive care unit (ICU) are fed via a nasogastric (NG) tube. Current guidance recommends continuous delivery of feed throughout the day and night. Emerging evidence from healthy human s... Read More about Does intermittent nutrition enterally normalise hormonal and metabolic responses to feeding in critically ill adults? A protocol for the dine-normal proof-of-concept randomised parallel group study.

Understanding women’s decision making for and against oncoplastic breast conserving surgery as an alternative to mastectomy in early breast cancer: UK ANTHEM qualitative study (2024)
Journal Article

ABSTRACT

Background: Oncoplastic breast conserving surgery (OPBCS) may allow women with early breast cancer to avoid mastectomy, but many women choose more extensive surgery even when breast conserving options are offered. Reasons for this are un... Read More about Understanding women’s decision making for and against oncoplastic breast conserving surgery as an alternative to mastectomy in early breast cancer: UK ANTHEM qualitative study.

Depressive symptoms in adolescence and adult educational and employment outcomes: A structured life course analysis (2024)
Journal Article

Background. Depression is a common mental health disorder that often starts during adolescence, with potentially important future consequences including ‘Not in Education, Employment or Training’ (NEET) status. Methods. We took a structured life cour... Read More about Depressive symptoms in adolescence and adult educational and employment outcomes: A structured life course analysis.

Developing emotional preparedness and mental resilience through high-fidelity simulation: A ‘bridge too far’ for institutions teaching major trauma management and mass-casualty medicine? (2024)
Journal Article

Background: Clinical acumen represents only part of being adequately equipped to attend a major incident. The emotive sights, sounds and smells of these dynamic environments are all-encompassing experiences, and responders must also be armed with the... Read More about Developing emotional preparedness and mental resilience through high-fidelity simulation: A ‘bridge too far’ for institutions teaching major trauma management and mass-casualty medicine?.