Outputs (162)

The effect of isocaloric, energy-restrictive, KETOgenic diet on metabolism, inflammation, nutrition deficiencies and oxidative stress in women with overweight and obesity (KETO-MINOX): Study protocol (2023)
Journal Article

Obesity is considered one of the biggest health problems of the 21st century, becoming a worldwide epidemic, leading to the development of many diseases and increasing the risk of premature death. The first step in reducing body weight is a calorie-r... Read More about The effect of isocaloric, energy-restrictive, KETOgenic diet on metabolism, inflammation, nutrition deficiencies and oxidative stress in women with overweight and obesity (KETO-MINOX): Study protocol.

The randomised thoracoscopic talc poudrage+indwelling pleural catheters versus thoracoscopic talc poudrage only in malignant pleural effusion trial (TACTIC): Study protocol for a randomised controlled trial (2023)
Journal Article

INTRODUCTION: Malignant pleural effusion (MPE) is common, with 50 000 new cases per year in the UK. MPE causes disabling breathlessness and indicates advanced disease with a poor prognosis. Treatment approaches focus on symptom relief and optimising... Read More about The randomised thoracoscopic talc poudrage+indwelling pleural catheters versus thoracoscopic talc poudrage only in malignant pleural effusion trial (TACTIC): Study protocol for a randomised controlled trial.

NanoBiT‐ and NanoBiT/BRET‐based assays allow the analysis of binding kinetics of Wnt‐3a to endogenous Frizzled 7 in a colorectal cancer model (2023)
Journal Article

Background and Purpose: Wnt binding to Frizzleds (FZD) is a crucial step that leads to the initiation of signalling cascades governing multiple processes during embryonic development, stem cell regulation and adult tissue homeostasis. Recent efforts... Read More about NanoBiT‐ and NanoBiT/BRET‐based assays allow the analysis of binding kinetics of Wnt‐3a to endogenous Frizzled 7 in a colorectal cancer model.

Impact of procedure type on revisional surgery and secondary reconstruction after immediate breast reconstruction in a population-based cohort (2023)
Journal Article

Background: Women considering immediate breast reconstruction require high-quality information about the likely need for secondary reconstruction and the long-term risk of revisional surgery to make fully informed decisions about different reconstruc... Read More about Impact of procedure type on revisional surgery and secondary reconstruction after immediate breast reconstruction in a population-based cohort.

Use of illness severity scores to predict mortality in interstitial lung disease patients hospitalised with acute respiratory deterioration (2023)
Journal Article

Introduction: Hospitalisations relating to acute respiratory deteriorations (ARD) in Interstitial Lung Disease (ILD) have poor outcomes. Factors predicting adverse outcomes are not fully understood and data addressing the use of illness severity scor... Read More about Use of illness severity scores to predict mortality in interstitial lung disease patients hospitalised with acute respiratory deterioration.

Sensitive periods for the effect of child maltreatment on psychopathology symptoms in adolescence (2023)
Journal Article

Introduction: Child maltreatment is among the strongest risk factors for mental disorders. However, little is known about whether there are ages when children may be especially vulnerable to its effects. We sought to identify potential sensitive peri... Read More about Sensitive periods for the effect of child maltreatment on psychopathology symptoms in adolescence.

Correct for the wrong reason: Why we should know more about mathematical common student errors in e-assessment questions (2023)
Journal Article

Students may arrive at an incorrect answer when answering a mathematical question due to several reasons, such as random errors, calculation errors or misreading the question. Such errors are sometimes referred to as Common Student Errors (CSEs). Thi... Read More about Correct for the wrong reason: Why we should know more about mathematical common student errors in e-assessment questions.

Predictive models in emergency medicine and their missing data strategies: a systematic review (2023)
Journal Article

In the field of emergency medicine (EM), the use of decision support tools based on artificial intelligence has increased markedly in recent years. In some cases, data are omitted deliberately and thus constitute “data not purposely collected” (DNPC)... Read More about Predictive models in emergency medicine and their missing data strategies: a systematic review.

Real world prospective evaluation of clinical outcomes in patients with non-metastatic castrate resistant prostate cancer treated with darolutamide (2023)
Presentation / Conference Contribution

Background: The RECORD Study is a real world data, prospective evaluation of clinical outcomes in patients with nmCRPC treated with Darolutamide. This study will increase the understanding of treatment response and management and in particular inform... Read More about Real world prospective evaluation of clinical outcomes in patients with non-metastatic castrate resistant prostate cancer treated with darolutamide.

The Bristol Bladder Trial: Five year outcomes in patients treated with neoadjuvant cabazitaxel and cisplatin chemotherapy for muscle invasive transitional cell carcinoma of the urinary bladder (2023)
Presentation / Conference Contribution

Background: Neoadjuvant cisplatin-based combination chemotherapy (NAC) improves survival in muscle invasive bladder cancer (MIBC). However, response rates and survival remain suboptimal. We sought to evaluate the efficacy of cabazitaxel with cisplati... Read More about The Bristol Bladder Trial: Five year outcomes in patients treated with neoadjuvant cabazitaxel and cisplatin chemotherapy for muscle invasive transitional cell carcinoma of the urinary bladder.

Applications of machine learning methods to assist the diagnosis of autism spectrum disorder (2023)
Book Chapter

Autism spectrum disorder (ASD) is a lifelong neuro-developmental disorder that is generally marked by a set of communication and social impairments. The early diagnosis of autism is genuinely beneficial for the welfare of children and parents as well... Read More about Applications of machine learning methods to assist the diagnosis of autism spectrum disorder.

Learning embeddings from free-text triage notes using pretrained transformer models (2022)
Presentation / Conference Contribution

The advent of transformer models has allowed for tremendous progress in the Natural Language Processing (NLP) domain. Pretrained transformers could successfully deliver the state-of-the-art performance in a myriad of NLP tasks. This study presents an... Read More about Learning embeddings from free-text triage notes using pretrained transformer models.

Eye-tracking dataset to support the research on autism spectrum disorder (2022)
Presentation / Conference Contribution

The availability of data is a key enabler for researchers across different disciplines. However, domains, such as healthcare, are still fundamentally challenged by the paucity and imbalance of datasets. Health data could be inaccessible due to a vari... Read More about Eye-tracking dataset to support the research on autism spectrum disorder.

Review of the partially overlapping samples framework: Paired observations and independent observations in two samples (2022)
Journal Article

A frequently asked question in quantitative research is how to compare two samples that include some combination of paired observations and unpaired observations. In our publications and R package, we refer to the scenario as ‘partially overlapping... Read More about Review of the partially overlapping samples framework: Paired observations and independent observations in two samples.

Vision-based approach for autism diagnosis using transfer learning and eye-tracking (2022)
Presentation / Conference Contribution

The potentials of Transfer Learning (TL) have been well-researched in areas such as Computer Vision and Natural Language Processing. This study aims to explore a novel application of TL to detect Autism Spectrum Disorder. We seek to develop an approa... Read More about Vision-based approach for autism diagnosis using transfer learning and eye-tracking.

Experimental validation of computerised models of clustering of platelet glycoprotein receptors that signal via tandem SH2 domain proteins (2022)
Journal Article

The clustering of platelet glycoprotein receptors with cytosolic YxxL and YxxM motifs, including GPVI, CLEC-2 and PEAR1, triggers activation via phosphorylation of the conserved tyrosine residues and recruitment of the tandem SH2 (Src homology 2) dom... Read More about Experimental validation of computerised models of clustering of platelet glycoprotein receptors that signal via tandem SH2 domain proteins.

BRIVEST: A ‘real-world’ observational, single-centre study investigating the efficacy, safety and tolerability of Brivaracetam (2022)
Journal Article

Objective: Via measures of efficacy, tolerability, and safety, this open-label, single-center study assessed the overall effectiveness of Brivaracetam (BRV) for the treatment of epilepsy in the context of ‘real-world’ clinical practice. Methods: Unse... Read More about BRIVEST: A ‘real-world’ observational, single-centre study investigating the efficacy, safety and tolerability of Brivaracetam.

Risk of disclosure when reporting commonly used univariate statistics (2022)
Presentation / Conference Contribution

When basic or descriptive summary statistics are reported, it may be possible that the entire sample of observations is inadvertently disclosed, or that members within a sample will be able to work out responses of others. Three sets of univariate su... Read More about Risk of disclosure when reporting commonly used univariate statistics.

Testing lifecourse theories characterising associations between maternal depression and offspring depression in emerging adulthood: The Avon Longitudinal Study of Parents and Children (2022)
Journal Article

Background: Maternal depression is a major determinant of offspring mental health. Yet, little is understood about how the duration and timing of maternal depression shapes youth risk for depressive symptoms, which if understood could inform when bes... Read More about Testing lifecourse theories characterising associations between maternal depression and offspring depression in emerging adulthood: The Avon Longitudinal Study of Parents and Children.

A collaboratively-derived research agenda for e-assessment in undergraduate mathematics (2022)
Journal Article

This paper describes the collaborative development of an agenda for research on e-assessment in undergraduate mathematics. We built on an established approach to develop the agenda from the contributions of 22 mathematics education researchers, unive... Read More about A collaboratively-derived research agenda for e-assessment in undergraduate mathematics.