Outputs (13)

RiHN Fina Report PDF 2023 (2023)
Report

Over a period of two years, the EPSRC funded RiHN brought together a multi-disciplinary network of academics stakeholder organisations, clinical groups and industry to provide a forum to define the challenges of realising Redistributed Manufacturing... Read More about RiHN Fina Report PDF 2023.

Innovation in healthcare: Developing the business case for redistributed manufacturing in deployed medical operations (2022)
Presentation / Conference Contribution

This paper explores the business case for ‘redistributed manufacturing’ (RDM) in deployed medical care. Employing an established approach, value stream mapping (VSM), we examine a manufacturing case from four priority areas: additive layer
manufactu... Read More about Innovation in healthcare: Developing the business case for redistributed manufacturing in deployed medical operations.

Humanitarian innovation: Defining the operational requirements for deployed healthcare (2022)
Presentation / Conference Contribution

This paper explores the role of Redistributed Manufacturing (RDM) in the delivery of humanitarian aid in response to disasters, conflict or emergencies. Humanitarian agencies must respond rapidly and with limited resources to address crises and deliv... Read More about Humanitarian innovation: Defining the operational requirements for deployed healthcare.

Innovation in deployed medical care: Building resilient healthcare supply chains (2022)
Presentation / Conference Contribution

For deployed medical operations, the delivery of critical healthcare products and services 'far forward' is a priority, calling for a radical shift away from existing modes of production and supply towards a more resilient, distributed approach terme... Read More about Innovation in deployed medical care: Building resilient healthcare supply chains.

The methylated N-terminal tail of RCC1 is required for stabilisation of its interaction with chromatin by Ran in live cells (2021)
Journal Article

μ-Opioid receptor desensitization: Homologous or heterologous? (2012)
Journal Article

There is considerable controversy over whether μ-opioid receptor (MOPr) desensitization is homologous or heterologous and over the mechanisms underlying such desensitization. In different cell types MOPr desensitization has been reported to involve r... Read More about μ-Opioid receptor desensitization: Homologous or heterologous?.

Phosphorylation of Mcl-1 by CDK1–cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest (2010)
Journal Article

The balance between cell cycle progression and apoptosis is important for both surveillance against genomic defects and responses to drugs that arrest the cell cycle. In this report, we show that the level of the human anti-apoptotic protein Mcl-1 is... Read More about Phosphorylation of Mcl-1 by CDK1–cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest.

Generation of cell-free extracts of Xenopus eggs and demembranated sperm chromatin for the assembly and isolation of in vitro-formed nuclei for Western blotting and scanning electron microscopy (SEM) (2007)
Journal Article

This protocol details methods for the generation of cell-free extracts and DNA templates from the eggs and sperm chromatin, respectively, of the clawed toad Xenopus laevis. We have used this system with scanning electron microscopy (SEM), as detailed... Read More about Generation of cell-free extracts of Xenopus eggs and demembranated sperm chromatin for the assembly and isolation of in vitro-formed nuclei for Western blotting and scanning electron microscopy (SEM).

A protocol for isolating Xenopus oocyte nuclear envelope for visualization and characterization by scanning electron microscopy (SEM) or transmission electron microscopy (TEM) (2007)
Journal Article

This protocol details methods for the isolation of oocyte nuclear envelopes (NEs) from the African clawed toad Xenopus laevis, immunogold labeling of component proteins and subsequent visualization by field-emission scanning electron microscopy (FESE... Read More about A protocol for isolating Xenopus oocyte nuclear envelope for visualization and characterization by scanning electron microscopy (SEM) or transmission electron microscopy (TEM).

A mitotic role for BRCA1/BARD1 in tumor suppression? (2006)
Journal Article

The tumor-suppressor protein BRCA1 is thought to act by preserving genomic integrity. In this issue of Cell, Joukov et al. (2006) demonstrate that the BRCA1/BARD1 heterodimer participates in mitotic spindle assembly, a process conducted by the GTPase... Read More about A mitotic role for BRCA1/BARD1 in tumor suppression?.

Cell biology: Ran, mitosis and the cancer connection (2006)
Journal Article

The small GTPase Ran has been shown to regulate HURP, a protein that interacts with several mitotic spindle assembly factors. This discovery sheds new light on the role of Ran in the fidelity of mitosis and in cancer. © 2006 Elsevier Ltd. All rights... Read More about Cell biology: Ran, mitosis and the cancer connection.

Nup214-Nup88 nucleoporin subcomplex is required for CRM1-mediated 60 S preribosomal nuclear export (2006)
Journal Article

The nuclear pore complex (NPC) conducts macromolecular transport to and from the nucleus and provides a kinetic/hydrophobic barrier composed of phenylalanine-glycine (FG) repeats. Nuclear transport is achieved through permeation of this barrier by tr... Read More about Nup214-Nup88 nucleoporin subcomplex is required for CRM1-mediated 60 S preribosomal nuclear export.

High resolution analysis of mammalian nuclear structure throughout the cell cycle: Implications for nuclear pore complex assembly during interphase and mitosis (2006)
Journal Article

Nuclear pore complexes (NPCs) are the gateways for both active and passive bidirectional molecular transport between the nucleoplasm and cytoplasm. These mega-dalton assemblies are composed of multiple copies of approximately 30 distinct proteins ter... Read More about High resolution analysis of mammalian nuclear structure throughout the cell cycle: Implications for nuclear pore complex assembly during interphase and mitosis.