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How hydrogen (H2) can support food security: From farm to fork (2024)
Journal Article
Russell, G., Nenov, A., & Hancock, J. T. (2024). How hydrogen (H2) can support food security: From farm to fork. Applied Sciences, 14(7), 2877. https://doi.org/10.3390/app14072877

Molecular hydrogen (H2) is a low-molecular-weight, non-polar and electrochemically neutral substance that acts as an effective antioxidant and cytoprotective agent, with research into the effects of H2 incorporation into the food chain, at various st... Read More about How hydrogen (H2) can support food security: From farm to fork.

An exploration of the direct biological targets of molecular hydrogen (2024)
Book Chapter
Hancock, J., May, J. E., LeBaron, T. W., Punampalam, R., & Russell, G. (2024). An exploration of the direct biological targets of molecular hydrogen. In J. Slezak, & B. Kura (Eds.), Molecular Hydrogen in Health and Disease (21-38). Springer. https://doi.org/10.1007/978-3-031-47375-3

Molecular hydrogen (H2), supplied either as a gas or in a solution, has been gaining popularity as a treatment for a variety of conditions and diseases. For example, it has been suggested to be beneficial for neurodegenerative diseases, to ease the i... Read More about An exploration of the direct biological targets of molecular hydrogen.

An interplay of gases: oxygen and hydrogen in biological systems (2024)
Journal Article
Russell, G., May, J., & Hancock, J. T. (2024). An interplay of gases: oxygen and hydrogen in biological systems. Oxygen, 4(1), 37-52. https://doi.org/10.3390/oxygen4010003

Produced by photosynthesis, oxygen (O2) is a fundamentally important gas in biological systems, playing roles as a terminal electron receptor in respiration and in host defence through the creation of reactive oxygen species (ROS). Hydrogen (H2) play... Read More about An interplay of gases: oxygen and hydrogen in biological systems.

Preharvest application of hydrogen sulfide and nitric oxide improves floral traits and postharvest performance of cut gladiolus inflorescences (2023)
Journal Article
Zulfiqar, F., Moosa, A., Darras, A., Nafees, M., Ashraf, M., Al-Ashkar, I., …Hancock, J. T. (2024). Preharvest application of hydrogen sulfide and nitric oxide improves floral traits and postharvest performance of cut gladiolus inflorescences. Journal of Plant Growth Regulation, 43, 1153–1165. https://doi.org/10.1007/s00344-023-11173-y

Gladiolus is a well-known bulbous plant producing impressive cut spikes. Hydrogen sulfide and nitric oxide are vital signaling molecules for the proper functioning of plant metabolism. Preharvest applications of these molecules to crops have gained a... Read More about Preharvest application of hydrogen sulfide and nitric oxide improves floral traits and postharvest performance of cut gladiolus inflorescences.

H2S priming and plant abiotic stress tolerance (2023)
Book Chapter
Silveira, N. M., Hancock, J., Machado, E. C., & Ribeiro, R. V. (2023). H2S priming and plant abiotic stress tolerance. In Plant Gasotransmiitters and Molecules with Hormonal Activity (245-262). Elsevier Academic Press. https://doi.org/10.1016/B978-0-323-99035-6.00008-7

Hydrogen sulfide (H2S) is an emerging multitasking signaling molecule involved in plant responses to many abiotic stresses, promoting tolerance and growth under limiting conditions. There is experimental evidence of cross talk between H2S and nitric... Read More about H2S priming and plant abiotic stress tolerance.

Reactive oxygen, nitrogen, and sulfur species cellular crosstalk (2023)
Book Chapter
Ziogas, V., Hancock, J. T., & Corpas, F. J. (2024). Reactive oxygen, nitrogen, and sulfur species cellular crosstalk. In Oxygen, nitrogen, and sulfur species in post-harvest physiology of horticultural crops (247-271). Elsevier Academic Press. https://doi.org/10.1016/B978-0-323-91798-8.00001-1

Accumulating data highlight the fact that nitric oxide (NO), hydrogen sulfide (H2S), and reactive oxygen species (ROS) act as intercellular key signaling molecules in plants. These molecules act in a well-orchestrated manner that regulates cells redo... Read More about Reactive oxygen, nitrogen, and sulfur species cellular crosstalk.

Molecular hydrogen as a beneficial postharvest treatment (2023)
Book Chapter
Hancock, J. T., LeBaron, T. W., May, J., Thomas, A., Zulfiqar, F., & Russell, G. (2024). Molecular hydrogen as a beneficial postharvest treatment. In V. Ziogas, & F. J. Corpas (Eds.), Oxygen, Nitrogen and Sulfur Species in Post-Harvest Physiology of Horticultural Crops (303-318). Elsevier. https://doi.org/10.1016/B978-0-323-91798-8.00011-4

Molecular hydrogen (H2) has been shown to have significant effects in plants, especially during stress responses. H2 treatment can be used as a gas or as an H2-enriched solution, often termed hydrogen-rich water (HRW). Cellular effects of H2 are ofte... Read More about Molecular hydrogen as a beneficial postharvest treatment.

The therapeutic potential of oxyhydrogen gas in oncology: A study on Epstein–Barr Virus-immortalised B-lymphoblastoid (TK6) cells (2023)
Journal Article
Russell, G., Thomas, A. D., Nenov, A., Mannings, G., & Hancock, J. T. (2023). The therapeutic potential of oxyhydrogen gas in oncology: A study on Epstein–Barr Virus-immortalised B-lymphoblastoid (TK6) cells. Hydrogen, 4(4), 746-759. https://doi.org/10.3390/hydrogen4040047

Cancer is a leading cause of mortality worldwide. B-cells are a keystone of the adaptive immune response and are essential for the presentation of tumor-associated antigens to various types of T-cells. Approximately 1.5% of global cancer cases, inclu... Read More about The therapeutic potential of oxyhydrogen gas in oncology: A study on Epstein–Barr Virus-immortalised B-lymphoblastoid (TK6) cells.

Nanotechnology improves disease resistance in plants for food security: Applications and challenges (2023)
Journal Article
Munir, N., Gulzar, W., Abideen, Z., Hancock, J. T., El-Keblawy, A., & Radicetti, E. (2023). Nanotechnology improves disease resistance in plants for food security: Applications and challenges. Biocatalysis and Agricultural Biotechnology, 51, Article 102781

Green synthesis of nano-fertilizers is emerging as a potential strategy and could play a crucial role in disease mitigation, diagnosis, or suppression. Different nanoscale devices (nanoparticles, NPs), biosensors, nano-diagnostic kits, nanofabricatio... Read More about Nanotechnology improves disease resistance in plants for food security: Applications and challenges.

Are protein cavities and pockets commonly used by redox active signalling molecules? (2023)
Journal Article
Hancock, J. T. (2023). Are protein cavities and pockets commonly used by redox active signalling molecules?. Plants, 12(14), 2594. https://doi.org/10.3390/plants12142594

It has been well known for a long time that inert gases, such as xenon (Xe), have significant biological effects. As these atoms are extremely unlikely to partake in direct chemical reactions with biomolecules such as proteins, lipids, and nucleic ac... Read More about Are protein cavities and pockets commonly used by redox active signalling molecules?.

Hydrogen incorporation into solvents can improve the extraction of phenolics, ‎flavonoids, anthocyanins, and antioxidants: A case-study using red beetroot (2023)
Journal Article
Alwazeer, D., Allam Elnasanelkasim, M., Çiğdem, A., ‎Engin, T., Kanmaz, H., Adnan Hayaloglu, A., …Hancock, J. T. (in press). Hydrogen incorporation into solvents can improve the extraction of phenolics, ‎flavonoids, anthocyanins, and antioxidants: A case-study using red beetroot. Industrial Crops and Products,

Different methods are used for extracting phytochemicals from plant produce. Some ‎methods require sophisticated and expensive instruments, while others need multiple steps ‎and specialist equipment, leading to an increase in energy, solvents, cost,... Read More about Hydrogen incorporation into solvents can improve the extraction of phenolics, ‎flavonoids, anthocyanins, and antioxidants: A case-study using red beetroot.

Why Elephants Cry: How Observing Unusual Animal Behaviours Can Predict the Weather (and other Environmental Phenomena) (2023)
Book
Hancock, J. (2023). Why Elephants Cry: How Observing Unusual Animal Behaviours Can Predict the Weather (and other Environmental Phenomena). Taylor & Francis (Routledge)

Why Elephants Cry is a fascinating frolic through the literature and evidence surrounding the use of unusual behavior of animals to measure and predict the environment. The role of animals, from the smallest ant to the biggest elephant, as predictors... Read More about Why Elephants Cry: How Observing Unusual Animal Behaviours Can Predict the Weather (and other Environmental Phenomena).

The on/off history of hydrogen in medicine: Will the interest persist this time around? (2023)
Journal Article
LeBaron, T. W., Ohno, K., & Hancock, J. T. (2023). The on/off history of hydrogen in medicine: Will the interest persist this time around?. Oxygen, 3(1), 143-162. https://doi.org/10.3390/oxygen3010011

Over 2000 publications including more than 100 human studies seem to indicate that humans have only recently benefited from or known about the medical effects of H2 within the past 15 years. However, we have unknowingly benefited from H2 since the da... Read More about The on/off history of hydrogen in medicine: Will the interest persist this time around?.

The early history of hydrogen and other gases in respiration and biological systems: Revisiting Beddoes, Cavallo, and Davy (2023)
Journal Article
Hancock, J. T., & LeBaron, T. W. (2023). The early history of hydrogen and other gases in respiration and biological systems: Revisiting Beddoes, Cavallo, and Davy. Oxygen, 3(1), 102-119. https://doi.org/10.3390/oxygen3010008

In 2007 a paper in Nature Medicine sparked a new wave of interest in the use of molecular hydrogen (H2) for medical treatments. Since then there has been a flurry of papers looking at a range of medical aspects, from neurodegenerative disease to spor... Read More about The early history of hydrogen and other gases in respiration and biological systems: Revisiting Beddoes, Cavallo, and Davy.

The genetic and biochemical mechanisms underlying cereal seed dormancy (2023)
Journal Article
Jing, S., Tian, Y., Zhang, H., T. Hancock, J., Zhu, Y., & Li, P. (2023). The genetic and biochemical mechanisms underlying cereal seed dormancy. Phyton-International Journal of Experimental Botany, 92(4), 1203-1214. https://doi.org/10.32604/phyton.2023.026305

The crop seeds have been a staple food for humans, and seed yield is important for sustaining agriculture development and enhancing human adaptability to food risks. The phenomenon of pre-harvest sprouting (PHS), caused by seed dormancy deficiency, a... Read More about The genetic and biochemical mechanisms underlying cereal seed dormancy.

The role of Salicylic acid signal in plant growth, development and abiotic stress (2022)
Journal Article
Hu, Y., Zhi, L., Li, P., T. Hancock, J. T., & Hu, X. (2022). The role of Salicylic acid signal in plant growth, development and abiotic stress. Phyton-International Journal of Experimental Botany, 91(12), 2591-2605. https://doi.org/10.32604/PHYTON.2022.023733

In nature, plants are constantly affected by adverse conditions. Unlike animals, plants can resist these adverse stresses only by insisting on their original positions. Stress can be divided into biological stress and abiotic stress, abiotic stress d... Read More about The role of Salicylic acid signal in plant growth, development and abiotic stress.

Research progress and application of plant branching (2022)
Journal Article
Yang, Y., Hu, Y., Li, P., T. Hancock, J., & Hu, X. (2022). Research progress and application of plant branching. Phyton-International Journal of Experimental Botany, 92(3), 679-689. https://doi.org/10.32604/phyton.2023.024904

Plant branching development plays an important role in plant morphogenesis (aboveground plant type), the number and angle of branches are important agronomic characters that determine crop plant type. Effective branches determine the number of panicl... Read More about Research progress and application of plant branching.

Understanding Hydrogen: Lessons to be learned from physical interactions between the inert gases and the globin superfamily (2022)
Journal Article
Hancock, J. T., Russell, G., Craig, T. J., May, J., Morse, H. R., & Stamler, J. S. (2022). Understanding Hydrogen: Lessons to be learned from physical interactions between the inert gases and the globin superfamily. Oxygen, 2(4), 578-590. https://doi.org/10.3390/oxygen2040038

Hydrogen gas (molecular hydrogen, H2) has significant effects in a range of organisms, from plants to humans. Many inert gases have been reported to have similar effects, and such responses may be most pronounced when cells are stressed. Xenon (Xe),... Read More about Understanding Hydrogen: Lessons to be learned from physical interactions between the inert gases and the globin superfamily.

Molecular Hydrogen: The postharvest use in fruits, vegetables and the floriculture industry (2022)
Journal Article
Hancock, J. T., Russell, G., & Stratakos, A. (2022). Molecular Hydrogen: The postharvest use in fruits, vegetables and the floriculture industry. Applied Sciences, 12(20), Article 10448. https://doi.org/10.3390/app122010448

Featured Application: It is proposed here that the use of molecular hydrogen should be considered more widely for the treatment of post-harvest fruits, vegetables and flowers. This can be applied as a gas, or in solution, and costs associated with it... Read More about Molecular Hydrogen: The postharvest use in fruits, vegetables and the floriculture industry.

The influence of molecular Hydrogen therapies in managing the symptoms of acute and chronic COVID-19 (2022)
Journal Article
Russell, G., Thomas, A., Nenov, A., & Hancock, J. (2022). The influence of molecular Hydrogen therapies in managing the symptoms of acute and chronic COVID-19. Medical Research Archives, 10(9), https://doi.org/10.18103/mra.v10i9.3036

Coronavirus Infectious Disease 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2) that emerged as a novel pathogen of global concern in the latter stages of 2019. COVID-19 is a highly contagio... Read More about The influence of molecular Hydrogen therapies in managing the symptoms of acute and chronic COVID-19.

The indirect impact of COVID-19 on the life of animals (2022)
Digital Artefact
Rana, M., Rouse, R., Craig, T. J., Macdonald, H., & Hancock, J. T. (2022). The indirect impact of COVID-19 on the life of animals. [website]

The COVID-19 pandemic is an ongoing major health crisis that is the result of the SARS-CoV-2 virus. The virus was first identified in Wuhan, China during December 2019; many patients were initially reported with pneumonia and later the cause was foun... Read More about The indirect impact of COVID-19 on the life of animals.

Chemical priming enhances plant tolerance to salt stress (2022)
Journal Article
Zulfiqar, F., Nafees, M., Chen, J., Darras, A., Ferrante, A., Hancock, J. T., …Siddique, K. H. (2022). Chemical priming enhances plant tolerance to salt stress. Frontiers in Plant Science, 13, 946922. https://doi.org/10.3389/fpls.2022.946922

Salt stress severely limits the productivity of crop plants worldwide and its detrimental effects are aggravated by climate change. Due to a significant world population growth, agriculture has expanded to marginal and salinized regions, which usuall... Read More about Chemical priming enhances plant tolerance to salt stress.

Phytochrome B enhances seed germination tolerance to high temperature by reducing S-nitrosylation of HFR1 (2022)
Journal Article
Ying, S., Yang, W., Li, P., Hu, Y., Lu, S., Zhou, Y., …Hu, X. (2022). Phytochrome B enhances seed germination tolerance to high temperature by reducing S-nitrosylation of HFR1. EMBO Reports, Article e54371. https://doi.org/10.15252/embr.202154371

Light and ambient high temperature (HT) have opposite effects on seed germination. Light induces seed germination through activating the photoreceptor phytochrome B (phyB), resulting in the stabilization of the transcription factor HFR1, which in tur... Read More about Phytochrome B enhances seed germination tolerance to high temperature by reducing S-nitrosylation of HFR1.

Editorial for special issue: “Production and role of molecular hydrogen in plants” (2022)
Journal Article
Hancock, J. T. (2022). Editorial for special issue: “Production and role of molecular hydrogen in plants”. Plants, 11(15), e2047. https://doi.org/10.3390/plants11152047

There seems little doubt that hydrogen gas (molecular hydrogen: H2) has significant effects on biological systems, including on plants. H2 can be administered as a gas, but more commonly is applied to plants as a solution which has been bubbled with... Read More about Editorial for special issue: “Production and role of molecular hydrogen in plants”.

Do SNPs in glutathione S-transferase-omega allow predictions of the susceptibility of vertebrates to SARS-CoV-2? (2022)
Journal Article
Hancock, J. T., Veal, D., Craig, T. J., & Rouse, R. C. (2022). Do SNPs in glutathione S-transferase-omega allow predictions of the susceptibility of vertebrates to SARS-CoV-2?. Reactive Oxygen Species, 12, c14–c29. https://doi.org/10.20455/ros.2022.c805

Infection with the SARS-Cov-2 virus causes COVID-19 in humans, and is the cause of the pandemic around the world in 2020 and on. However, some animals have been found to be susceptible to the virus too. This has included the non-human primates, dogs,... Read More about Do SNPs in glutathione S-transferase-omega allow predictions of the susceptibility of vertebrates to SARS-CoV-2?.

Nitric oxide-releasing nanomaterials: From basic research to potential biotechnological applications in agriculture (2022)
Journal Article
Seabra, A. B., Silveira, N. M., Ribeiro, R. V., Pieretti, J. C., Barroso, J. B., Corpas, F. J., …Oliveira, H. C. (2022). Nitric oxide-releasing nanomaterials: From basic research to potential biotechnological applications in agriculture. New Phytologist, 234(4), 1119-1125. https://doi.org/10.1111/nph.18073

Nitric oxide (NO) is a multifunctional gaseous signal that modulates the growth, development and stress tolerance of higher plants. NO donors have been used to boost plant endogenous NO levels and to activate NO-related responses, but this strategy i... Read More about Nitric oxide-releasing nanomaterials: From basic research to potential biotechnological applications in agriculture.

Molecular hydrogen as medicine: An assessment of administration methods (2021)
Journal Article
Russell, G., Nenov, A., Kisher, H., & Hancock, J. T. (2021). Molecular hydrogen as medicine: An assessment of administration methods. Hydrogen, 2(4), 444-460. https://doi.org/10.3390/hydrogen2040025

Since the late 18th century, molecular hydrogen (H2) has been shown to be well tolerated, firstly in animals, and then in humans. However, although research into the beneficial effects of molecular hydrogen in both plant and mammalian physiology is g... Read More about Molecular hydrogen as medicine: An assessment of administration methods.

Molecular hydrogen: Is this a viable new treatment for plants in the UK? (2021)
Journal Article
Hancock, J. T., LeBaron, T. W., May, J., Thomas, A., & Russell, G. (2021). Molecular hydrogen: Is this a viable new treatment for plants in the UK?. Plants, 10(11), Article 2270

Despite being trialed in other regions of the world, the use of molecular hydrogen (H2) for enhanced plant growth and postharvest storage of crops has yet to be widely accepted in the UK. The evidence continues to grow that treatment of plants and pl... Read More about Molecular hydrogen: Is this a viable new treatment for plants in the UK?.

Molecular hydrogen in agriculture (2021)
Journal Article
Zulfiqar, F., Russell, G., & Hancock, J. T. (2021). Molecular hydrogen in agriculture. Planta, 254(3), Article 56. https://doi.org/10.1007/s00425-021-03706-0

Main conclusion: H2 gas, usually in the form of H2-saturated water, could play a useful role in improving many aspects of plant growth and productivity, including resistance to stress tolerance and improved post-harvest durability. Therefore, molecul... Read More about Molecular hydrogen in agriculture.

Oxygen is instrumental for biological signalling: An overview (2021)
Journal Article
Hancock, J. (2021). Oxygen is instrumental for biological signalling: An overview. Oxygen, 1(1), 3-15. https://doi.org/10.3390/oxygen1010002

Control of cellular function is extremely complex, being reliant on a wide range of components. Several of these are small oxygen-based molecules. Although reactive compounds containing oxygen are usually harmful to cells when accumulated to relative... Read More about Oxygen is instrumental for biological signalling: An overview.

Cell Signalling (2021)
Book
Hancock, J. (2021). Cell Signalling. Oxford: Oxford University Press

Molecular hydrogen: Redox reactions and possible biological interactions (2021)
Journal Article
Hancock, J. T., LeBaron, T. W., & Russell, G. (2021). Molecular hydrogen: Redox reactions and possible biological interactions. Reactive Oxygen Species, 11, m17–m25. https://doi.org/10.20455/ros.2021.m.803

Molecular hydrogen (H2), either as a gas or as hydrogen-rich water (HRW), is suggested to be a useful treatment for a range of human diseases and also to improve agricultural output. It is often posited that H2 accomplishes its biological action, in... Read More about Molecular hydrogen: Redox reactions and possible biological interactions.

Oxy-hydrogen gas: The rationale behind its use as a novel and sustainable treatment for COVID-19 and other respiratory diseases (2021)
Journal Article
Russell, G., Nenov, A., & Hancock, J. (2021). Oxy-hydrogen gas: The rationale behind its use as a novel and sustainable treatment for COVID-19 and other respiratory diseases. European Medical Journal, May 2021, https://doi.org/10.33590/emj/21-00027

Oxy-hydrogen gas (HHO) is a gaseous mixture of molecular hydrogen (H2) and molecular oxygen (O2) that is generated by the electrolysis of water and delivered in a 2:1 ratio (66% and 33%, respectively) through the use of non-invasive inhalation device... Read More about Oxy-hydrogen gas: The rationale behind its use as a novel and sustainable treatment for COVID-19 and other respiratory diseases.

Interacting proteins, polymorphisms and the susceptibility of animals to SARS-CoV-2 (2021)
Journal Article
Hancock, J., Rouse, R., Stone, E., & Greenhough, A. (2021). Interacting proteins, polymorphisms and the susceptibility of animals to SARS-CoV-2. Animals, 11(3), Article 797. https://doi.org/10.3390/ani11030797

Abstract: COVID-19, caused by SARS-CoV-2, is a world-wide problem for the human population. It is known that some animal species, such as mink, can become infected and transmit the virus. However, the susceptibility of most animals is not known. Here... Read More about Interacting proteins, polymorphisms and the susceptibility of animals to SARS-CoV-2.

Leaf arginine spraying improves leaf gas exchange under water deficit and root antioxidant responses during the recovery period (2021)
Journal Article
Silveira, N. M., Ribeiro, R. V., de Morais, S. F. N., de Souza, S. C. R., da Silva, S. F., Seabra, A. B., …Machado, E. C. (2021). Leaf arginine spraying improves leaf gas exchange under water deficit and root antioxidant responses during the recovery period. Plant Physiology and Biochemistry, 162, 315-326. https://doi.org/10.1016/j.plaphy.2021.02.036

© 2021 Elsevier Masson SAS Arginine (Arg) metabolism is associated with many cellular and developmental processes in plants and proline, nitric oxide (NO) and polyamines (PAs) have a wide range of physiological functions in plants, including increase... Read More about Leaf arginine spraying improves leaf gas exchange under water deficit and root antioxidant responses during the recovery period.

Downstream signalling from molecular hydrogen (2021)
Journal Article
Hancock, J., & Russell, G. (2021). Downstream signalling from molecular hydrogen. Plants, 10(2), Article 367. https://doi.org/10.3390/plants10020367

Molecular hydrogen (H2) is now considered to be a part of the suite of small molecules which can control cellular activity. As such it has been suggested to be used in the therapy of diseases in humans but also to be used in plant science, to enhance... Read More about Downstream signalling from molecular hydrogen.

The effects of seed priming with sodium hydrosulphide on drought tolerance of sunflower (Helianthus annuus L.) in germination and early growth (2020)
Journal Article
Ocvirk, D., Špoljarević, M., Kristić, M., Hancock, J. T., Teklić, T., & Lisjak, M. (2021). The effects of seed priming with sodium hydrosulphide on drought tolerance of sunflower (Helianthus annuus L.) in germination and early growth. Annals of Applied Biology, 178(2), 400-413. https://doi.org/10.1111/aab.12658

© 2020 Association of Applied Biologists Sunflower seeds (hybrid Luka) were primed with water (hydropriming) or sodium hydrosulphide (NaHS) solutions (0.1, 0.5, 1.0 and 1.5 mM NaHS) and subsequently dried to initial moisture content. Unprimed (contro... Read More about The effects of seed priming with sodium hydrosulphide on drought tolerance of sunflower (Helianthus annuus L.) in germination and early growth.

Hydrogenases and the role of molecular hydrogen in plants (2020)
Journal Article
Russell, G., Zulfiqar, F., & Hancock, J. T. (2020). Hydrogenases and the role of molecular hydrogen in plants. Plants, 9(9), 1-15. https://doi.org/10.3390/plants9091136

Molecular hydrogen (H2) has been suggested to be a beneficial treatment for a range of species, from humans to plants. Hydrogenases catalyze the reversible oxidation of H2, and are found in many organisms, including plants. One of the cellular effect... Read More about Hydrogenases and the role of molecular hydrogen in plants.

Hydrogen sulfide in horticulture: Emerging roles in the era of climate change (2020)
Journal Article
Zulfiqar, F., & Hancock, J. T. (2020). Hydrogen sulfide in horticulture: Emerging roles in the era of climate change. Plant Physiology and Biochemistry, 155, 667-675. https://doi.org/10.1016/j.plaphy.2020.08.010

Future climate change will present many plants with environmental challenges, including extreme temperatures and drought. Hydrogen sulfide (H2S) has emerged as an important signal transmitting molecule in plants, especially important in many stress r... Read More about Hydrogen sulfide in horticulture: Emerging roles in the era of climate change.

Nitric oxide, other reactive signalling compounds, redox, and reductive stress (2020)
Journal Article
Hancock, J., & Veal, D. (2021). Nitric oxide, other reactive signalling compounds, redox, and reductive stress. Journal of Experimental Botany, 72(3), 819-829. https://doi.org/10.1093/jxb/eraa331

Nitric oxide (NO) and other reactive nitrogen species (RNS) are key signalling molecules in plants, but they do not work in isolation. NO is produced in cells, often increased in response to stress conditions, but many other reactive compounds used i... Read More about Nitric oxide, other reactive signalling compounds, redox, and reductive stress.

An overview of SARS-CoV-2 (COVID-19) infection and the importance of molecular hydrogen as an adjunctive therapy (2020)
Journal Article
Russell, G., Rehman, M., LeBaron, T. W., Veal, D., Adukwu, E., & Hancock, J. (2020). An overview of SARS-CoV-2 (COVID-19) infection and the importance of molecular hydrogen as an adjunctive therapy. Reactive Oxygen Species, 10(28), 150–165

SARS-CoV-2 is an emerging β-coronavirus that causes COVID-19 disease that manifests primarily as a pulmonary infection that can rapidly progress into severe and acute respiratory distress in susceptible patients. Initial reports of severe pulmonary i... Read More about An overview of SARS-CoV-2 (COVID-19) infection and the importance of molecular hydrogen as an adjunctive therapy.

Regulating the regulator: nitric oxide control of post-translational modifications (2020)
Journal Article
Gupta, K. J., Kolbert, Z., Durner, J., Lindermayr, C., Corpas, F. J., Brouquisse, R., …Loake, G. J. (2020). Regulating the regulator: nitric oxide control of post-translational modifications. New Phytologist, 227(5), 1319-1325. https://doi.org/10.1111/nph.16622

Nitric oxide (NO) is perfectly suited for the role of a redox signalling molecule. A key route for NO bioactivity occurs via protein S-nitrosation, and involves the addition of a NO moiety to a protein cysteine (Cys) thiol (–SH) to form an S-nitrosot... Read More about Regulating the regulator: nitric oxide control of post-translational modifications.

Is glyceraldehyde-3-phosphate dehydrogenase a central redox mediator? (2020)
Journal Article
Russell, G., Veal, D., & Hancock, J. T. (2020). Is glyceraldehyde-3-phosphate dehydrogenase a central redox mediator?. Reactive Oxygen Species, 9(26), 48-69

D-Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an immensely important enzyme carrying out a vital step in glycolysis and is found in all living organisms. Although there are several isoforms identified in many species, it is now recognized tha... Read More about Is glyceraldehyde-3-phosphate dehydrogenase a central redox mediator?.

Nitric Oxide-Induced Tolerance in Plants under Adverse Environmental Conditions (2019)
Book Chapter
NM, S., B, S., EC, M., JT, H., & RV, R. (2019). Nitric Oxide-Induced Tolerance in Plants under Adverse Environmental Conditions. In T. Islam, H. Oku, M. Fujita, K. Nahar, & M. Hasanuzzaman (Eds.), Approaches for Enhancing Abiotic Stress Tolerance in Plants. , (371-385). Bangladesh: Taylor & Francis

A forty year journey: The generation and roles of NO in plants (2019)
Journal Article
Kolbert, Z., Barroso, J. B., Brouquisse, R., Corpas, F. J., Gupta, K. J., Lindermayr, C., …Hancock, J. (2019). A forty year journey: The generation and roles of NO in plants. Nitric Oxide: Biology and Chemistry, 93, 53-70. https://doi.org/10.1016/j.niox.2019.09.006

In this year there is the 40th anniversary of the first publication of plant nitric oxide (NO) emission by Lowell Klepper. In the decades since then numerous milestone discoveries have revealed that NO is a multifunctional molecule in plant cells reg... Read More about A forty year journey: The generation and roles of NO in plants.

Recommendations on terminology and experimental best practice associated with plant nitric oxide research (2019)
Journal Article
Gupta, K. J., Hancock, J. T., Petrivalsky, M., Kolbert, Z. S., Lindermayr, C., Durner, J., …John Loake, G. (2020). Recommendations on terminology and experimental best practice associated with plant nitric oxide research. New Phytologist, 225(5), 1828-1834. https://doi.org/10.1111/nph.16157

© 2019 The Authors. New Phytologist © 2019 New Phytologist Trust Nitric oxide (NO) emerged as a key signal molecule in plants. During the last two decades impressive progress has been made in plant NO research. This small, redox-active molecule is no... Read More about Recommendations on terminology and experimental best practice associated with plant nitric oxide research.

Network theory and the resilience of redox signaling (2019)
Journal Article
Hancock, J. T., Veal, D., & Hancock, A. L. (2019). Network theory and the resilience of redox signaling. Reactive Oxygen Species, 8(23), 245-257

The redox status inside and around cells is critically important to control, being used to maintain reduced compounds in the correct state and for cell signaling mechanisms. A myriad of compounds and proteins are involved in a vast network system to... Read More about Network theory and the resilience of redox signaling.

Equations to support redox experimentation (2019)
Book Chapter
Hancock, J. T., & Whiteman, M. Equations to support redox experimentation. In J. T. Hancock, & M. E. Conway (Eds.), Redox-Mediated Signal Transduction (183-195). Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9463-2_15

© Springer Science+Business Media, LLC, part of Springer Nature 2019. Working with redox compounds needs to take into account the oxidation and reduction state of the compound under study. This redox state can be influenced by the media in which the... Read More about Equations to support redox experimentation.

Methods for the addition of redox compounds (2019)
Book Chapter
Hancock, J. T. Methods for the addition of redox compounds. In J. T. Hancock, & M. E. Conway (Eds.), Redox-Mediated Signal Transduction (13-25). Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9463-2_2

© Springer Science+Business Media, LLC, part of Springer Nature 2019. Often in redox biology experiments there is a need to add compounds which impinge on the redox of the cellular environment cell. Such compounds may include reactive oxygen species... Read More about Methods for the addition of redox compounds.

Investigating ROS, RNS, and H2S-sensitive signaling proteins (2019)
Book Chapter
Williams, E., Whiteman, M., Wood, M. E., Wilson, I. D., Ladomery, M. R., Allainguillaume, J., …Hancock, J. T. (2019). Investigating ROS, RNS, and H2S-sensitive signaling proteins. In J. T. Hancock, & M. E. Conway (Eds.), Redox-Mediated Signal Transduction (27-42). Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9463-2_3

© Springer Science+Business Media, LLC, part of Springer Nature 2019. The modification of proteins is a key way to alter their activity and function. Often thiols, cysteine residues, on proteins are attractive targets for such modification. Assuming... Read More about Investigating ROS, RNS, and H2S-sensitive signaling proteins.

Predicting the effects of low dose-rate ionizing radiation on redox potential in plant cells (2019)
Book Chapter
Caplin, N., & Willey, N. (2019). Predicting the effects of low dose-rate ionizing radiation on redox potential in plant cells. In J. T. Hancock, & M. E. Conway (Eds.), Redox-Mediated Signal Transduction, (135-142). New York, USA: Humana. https://doi.org/10.1007/978-1-4939-9463-2_11

During exposure of cells to acute high dose-rate ionizing radiation (IR), oxidants from the radiolysis of water can overwhelm antioxidant systems. Protecting flora from the effects of IR released from a nuclear industry of increasing global significa... Read More about Predicting the effects of low dose-rate ionizing radiation on redox potential in plant cells.

Considerations of the importance of redox state for reactive nitrogen species action (2019)
Journal Article
Hancock, J. T. (2019). Considerations of the importance of redox state for reactive nitrogen species action. Journal of Experimental Botany, 70(17), 4323-4331. https://doi.org/10.1093/jxb/erz067

Nitric oxide (NO) and other reactive nitrogen species (RNS) are immensely important signalling molecules in plants, being involved in a range of physiological responses. However, the exact way in which NO fits into signal transduction pathways is not... Read More about Considerations of the importance of redox state for reactive nitrogen species action.

Nitric oxide: Its generation and interactions with other reactive signaling compounds (2019)
Journal Article
Hancock, J. T., & Neill, S. J. (2019). Nitric oxide: Its generation and interactions with other reactive signaling compounds. Plants, 8(2), 41. https://doi.org/10.3390/plants8020041

Nitric oxide (NO) is an immensely important signaling molecule in animals and plants. It is involved in plant reproduction, development, key physiological responses such as stomatal closure, and cell death. One of the controversies of NO metabolism i... Read More about Nitric oxide: Its generation and interactions with other reactive signaling compounds.

The role of redox in signal transduction (2019)
Book Chapter
Hancock, J. T. (2019). The role of redox in signal transduction. In J. T. Hancock, & M. E. Conway (Eds.), Redox-Mediated Signal Transduction (1-11). Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9463-2_1

© Springer Science+Business Media, LLC, part of Springer Nature 2019. It is the functioning of efficient cell signaling which is vital for the survival of cells, whether it is a simple prokaryote or a complex eukaryote, including both animals and pla... Read More about The role of redox in signal transduction.

Hydrogen gas, ROS metabolism and cell signaling: Are hydrogen spin states important? (2018)
Journal Article
Hancock, J. T., & Hancock, T. H. (2018). Hydrogen gas, ROS metabolism and cell signaling: Are hydrogen spin states important?. Reactive Oxygen Species, 6(18),

It is becoming accepted that treatment with hydrogen gas (H2) has profound and often beneficial effects on cells from both animals and plants. Future uses which have been suggested include for cancer treatment, for alleviating symptoms of Parkinson’s... Read More about Hydrogen gas, ROS metabolism and cell signaling: Are hydrogen spin states important?.

Hydrogen sulfide and environmental stresses (2018)
Journal Article
Hancock, J. T. (2019). Hydrogen sulfide and environmental stresses. Environmental and Experimental Botany, 161, 50-56. https://doi.org/10.1016/j.envexpbot.2018.08.034

© 2018 Elsevier B.V. Hydrogen sulfide (H 2 S) is part of a suite of small reactive molecules which are known to be involved in cell signaling events in plants. It is produced by cells, can move around, including through membranes, and can be removed... Read More about Hydrogen sulfide and environmental stresses.

Reactive oxygen species, nitric oxide and hydrogen sulfide in plant cell regulation (2018)
Journal Article
Hancock, J., & Whiteman, M. (2018). Reactive oxygen species, nitric oxide and hydrogen sulfide in plant cell regulation. Free Radical Biology and Medicine, 120(S1), s9. https://doi.org/10.1016/j.freeradbiomed.2018.04.040

Growth and maintenance of cells is partly controlled by the production and perception of a range of small relatively reactive molecules, including reactive oxygen species, nitric oxide and hydrogen sulfide: what may be dubbed reactive signaling molec... Read More about Reactive oxygen species, nitric oxide and hydrogen sulfide in plant cell regulation.

Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells (2018)
Journal Article
Bowler, E., Porazinski, S., Uzor, S., Thibault, P., Durand, M., Lapointe, E., …Ladomery, M. (2018). Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells. BMC Cancer, 18(1), 355. https://doi.org/10.1186/s12885-018-4227-7

© 2018 The Author(s). Background: Mounting evidence suggests that one of the ways that cells adapt to hypoxia is through alternative splicing. The aim of this study was firstly to examine the effect of hypoxia on the alternative splicing of cancer as... Read More about Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells.

Signaling through the primary cilium (2018)
Journal Article
Wheway, G., Nazlamova, L., & Hancock, J. T. (2018). Signaling through the primary cilium. Frontiers in Cell and Developmental Biology, 6(FEB), https://doi.org/10.3389/fcell.2018.00008

© 2018 Wheway, Nazlamova and Hancock. The presence of single, non-motile "primary" cilia on the surface of epithelial cells has been well described since the 1960s. However, for decades these organelles were believed to be vestigial, with no remainin... Read More about Signaling through the primary cilium.

Cellular redox environment and its influence on redox signalling molecules (2018)
Journal Article
Hancock, J. T., & Whiteman, M. (2018). Cellular redox environment and its influence on redox signalling molecules. Reactive Oxygen Species, 5(14),

The redox potential of a cell’s internal environment is well recognised as important for controlling cellular activities. Both animal and plant cells generate and are exposed to a range of reactive molecules involved in cell signalling, including rea... Read More about Cellular redox environment and its influence on redox signalling molecules.

Hydrogen gas and its role in cell signaling (2017)
Journal Article
Wilson, H. R., Veal, D., Whiteman, M., & Hancock, J. T. (2017). Hydrogen gas and its role in cell signaling. CABI Reviews, 12, 2-3

Hydrogen gas (H2) was once thought to be inert in biological systems but it has now become apparent that exposure of a wide range of organisms, including animals and plants, to H2 or hydrogen-rich water (HRW) has beneficial effects. It is involved in... Read More about Hydrogen gas and its role in cell signaling.

Identification and functional annotation of genes differentially expressed in the reproductive tissues of the olive tree (Olea europaea L.) through the generation of subtractive libraries (2017)
Journal Article
Zafra, A., Carmona, R., Traverso, J. A., Hancock, J. T., Goldman, M. H., Claros, M. G., …Alche, J. D. (2017). Identification and functional annotation of genes differentially expressed in the reproductive tissues of the olive tree (Olea europaea L.) through the generation of subtractive libraries. Frontiers in Plant Science, 8, Article 1576. https://doi.org/10.3389/fpls.2017.01576

© 2017 Zafra, Carmona, Traverso, Hancock, Goldman, Claros, Hiscock and Alche. The olive tree is a crop of high socio-economical importance in the Mediterranean area. Sexual reproduction in this plant is an essential process, which determines the yiel... Read More about Identification and functional annotation of genes differentially expressed in the reproductive tissues of the olive tree (Olea europaea L.) through the generation of subtractive libraries.

Residual ground-water levels of the neonicotinoid thiacloprid perturb chemosensing of Caenorhabditis elegans (2017)
Journal Article
Floyd, K. G., Hopewell, H., Burnell, D., Hancock, J. T., Allainguillaume, J., Ladomery, M., & Wilson, I. D. (2017). Residual ground-water levels of the neonicotinoid thiacloprid perturb chemosensing of Caenorhabditis elegans. Ecotoxicology, 26(7), 981-990. https://doi.org/10.1007/s10646-017-1826-z

© 2017, The Author(s). This study investigated the neurological effects of residual ground-water levels of thiaclopridon the non-target organism Caenorhabditis elegans. Nematodes treated with thiacloprid showed a dose-dependent and significantly incr... Read More about Residual ground-water levels of the neonicotinoid thiacloprid perturb chemosensing of Caenorhabditis elegans.

Hydrogen sulfide causes excision of a genomic island in Pseudomonas syringae pv. phaseolicola (2017)
Journal Article
Neale, H., Deshappriya, N., Arnold, D. L., Wood, M. E., Whiteman, M., & Hancock, J. T. (2017). Hydrogen sulfide causes excision of a genomic island in Pseudomonas syringae pv. phaseolicola. European Journal of Plant Pathology, 149(4), 911-921. https://doi.org/10.1007/s10658-017-1240-7

© 2017, The Author(s). Hydrogen sulfide (H2S) is known to be an important signalling molecule in both animals and plants, despite its toxic nature. In plants it has been seen to control stomatal apertures, so altering the ability of bacteria to invad... Read More about Hydrogen sulfide causes excision of a genomic island in Pseudomonas syringae pv. phaseolicola.

S-nitrosoglutathione spraying improves stomatal conductance, Rubisco activity and antioxidant defense in both leaves and roots of sugarcane plants under water deficit (2017)
Journal Article
Silveira, N. M., Marcos, F. C., Frungillo, L., Moura, B. B., Seabra, A. B., Salgado, I., …Ribeiro, R. V. (2017). S-nitrosoglutathione spraying improves stomatal conductance, Rubisco activity and antioxidant defense in both leaves and roots of sugarcane plants under water deficit. Physiologia Plantarum, 160(4), 383-395. https://doi.org/10.1111/ppl.12575

© 2017 Scandinavian Plant Physiology Society Water deficit is a major environmental constraint on crop productivity and performance and nitric oxide (NO) is an important signaling molecule associated with many biochemical and physiological processes... Read More about S-nitrosoglutathione spraying improves stomatal conductance, Rubisco activity and antioxidant defense in both leaves and roots of sugarcane plants under water deficit.

Evidence towards the involvement of nitric oxide in drought tolerance of sugarcane (2017)
Journal Article
Ribeiro, R. V., Silveira, N. M., Hancock, J. T., Frungillo, L., Siasou, E., Marcos, F. C., …Machado, E. C. (2017). Evidence towards the involvement of nitric oxide in drought tolerance of sugarcane. Plant Physiology and Biochemistry, 115, 354-359. https://doi.org/10.1016/j.plaphy.2017.04.011

© 2017 Elsevier Masson SAS Exogenous supply of nitric oxide (NO) increases drought tolerance in sugarcane plants. However, little is known about the role of NO produced by plants under water deficit. The aim of this study was to test the hypothesis t... Read More about Evidence towards the involvement of nitric oxide in drought tolerance of sugarcane.

Harnessing evolutionary toxins for signaling: Reactive oxygen species, nitric oxide and hydrogen sulfide in plant cell regulation (2017)
Journal Article
Hancock, J. T. (2017). Harnessing evolutionary toxins for signaling: Reactive oxygen species, nitric oxide and hydrogen sulfide in plant cell regulation. Frontiers in Plant Science, 8, 189. https://doi.org/10.3389/fpls.2017.00189

© 2017 Hancock. During the early periods of evolution, as well as in niche environments today, organisms have had to learn to tolerate the presence of many reactive compounds, such as reactive oxygen species, nitric oxide, and hydrogen sulfide. It is... Read More about Harnessing evolutionary toxins for signaling: Reactive oxygen species, nitric oxide and hydrogen sulfide in plant cell regulation.

Nitric oxide signalling in plants (2017)
Book Chapter
Hancock, J. T., Wilson, H. R., & Neill, S. (2017). Nitric oxide signalling in plants. In eLS. Chichester: Wiley. https://doi.org/10.1002/9780470015902.a0020109.pub2

Nitric oxide (NO) is a small simple molecule but one which is instrumental in cell signalling in a range of organisms including plants. It is a gas, often found in the form of a radical. It is produced in cells in an orchestrated manner, usually by d... Read More about Nitric oxide signalling in plants.

Competition of reactive signals and thiol modifications of proteins (2017)
Journal Article
Hancock, J. T., Craig, T. J., & Whiteman, M. (2017). Competition of reactive signals and thiol modifications of proteins. https://doi.org/10.4172/2576-1471.1000170

It is clear that cells are constantly bombarded by multiple signals, often initiating similar, or even conflicting, responses. Important players in this suite of signals are the reactive oxygen species (ROS), such as hydrogen peroxide (H2O2), the rea... Read More about Competition of reactive signals and thiol modifications of proteins.

Cell Signalling (2016)
Book
Hancock, J. T. (2016). Cell Signalling. Oxford: Oxford University Press

4th Edition of Cell Signalling published by OUP

Hydrogen sulfide signaling: Interactions with nitric oxide and reactive oxygen species (2016)
Journal Article
Hancock, J. T., & Whiteman, M. (2016). Hydrogen sulfide signaling: Interactions with nitric oxide and reactive oxygen species. Annals of the New York Academy of Sciences, 1365(1), 5-14. https://doi.org/10.1111/nyas.12733

© 2016 The New York Academy of Sciences. Signaling in cells involving reactive compounds is well established. Reactive oxygen species (ROS) and nitric oxide (NO) are known to be extremely influential in the control of a range of physiological respons... Read More about Hydrogen sulfide signaling: Interactions with nitric oxide and reactive oxygen species.

Alone NO Longer: Interactions of Nitric Oxide with Reactive Oxygen Species and Hydrogen Sulfide (2016)
Journal Article
Whiteman, M., Hancock, J. T., & Whiteman, M. (2016). Alone NO Longer: Interactions of Nitric Oxide with Reactive Oxygen Species and Hydrogen Sulfide. Advances in Botanical Research, 77, 1-14. https://doi.org/10.1016/bs.abr.2015.10.012

Nitric oxide (NO) is a hugely important signaling molecule in both animals and plants. In plants, it has been implicated in the control of a host of cellular and physiological events, from roots to leaves, from germination to senescence. It is known... Read More about Alone NO Longer: Interactions of Nitric Oxide with Reactive Oxygen Species and Hydrogen Sulfide.

Oxidative stress and redox signalling in plants (2016)
Book Chapter
Hancock, J. T. (2016). Oxidative stress and redox signalling in plants. In eLS. Wiley. https://doi.org/10.1002/9780470015902.a0026508

Cell signalling is a critically important aspect of biology, being the mechanism by which organisms, tissues and cells coordinate their activity, and survive environmental change and stress. Numerous bio-molecules are involved but small reactive comp... Read More about Oxidative stress and redox signalling in plants.

Hydrogen sulfide and reactive friends: The interplay with reactive oxygen species and nitric oxide signalling pathways (2015)
Book Chapter
Hancock, J. T., & Whiteman, M. (2015). Hydrogen sulfide and reactive friends: The interplay with reactive oxygen species and nitric oxide signalling pathways. In L. de Kok, M. Hawkesford, H. Rennenberg, & K. Saito (Eds.), Molecular Physiology and Ecophysiology of Sulfur (153-168). Springer. https://doi.org/10.1007/978-3-319-20137-5_16

Hydrogen sulfide (H2S) is now considered to be a signalling molecule in a range of organisms. In animals and plants there are characterised mechanisms for its generation and removal suggesting that it can be made and have an effect when required. In... Read More about Hydrogen sulfide and reactive friends: The interplay with reactive oxygen species and nitric oxide signalling pathways.

The identification of genes important in pseudomonas syringae pv. phaseolicola plant colonisation using in vitro screening of transposon libraries (2015)
Journal Article
Manoharan, B., Neale, H. C., Hancock, J. T., Jackson, R. W., & Arnold, D. L. (2015). The identification of genes important in pseudomonas syringae pv. phaseolicola plant colonisation using in vitro screening of transposon libraries. PLoS ONE, 10(9), Article e0137355. https://doi.org/10.1371/journal.pone.0137355

© 2015 Manoharan et al. The bacterial plant pathogen Pseudomonas syringae pv. phaseolicola (Pph) colonises the surface of common bean plants before moving into the interior of plant tissue, via wounds and stomata. In the intercellular spaces the path... Read More about The identification of genes important in pseudomonas syringae pv. phaseolicola plant colonisation using in vitro screening of transposon libraries.

H2S and NO signalling in plants (2015)
Presentation / Conference
Lisjak, M., Spoljarevic, M., Wood, M. E., Whiteman, M., Wilson, I. D., Hancock, J. T., & Teklic, T. (2015, June). H2S and NO signalling in plants. Presented at 2nd International Conference on Plant Biology, Petnica, Serbia, Russia

Besides already well known actions in animal organisms and described effects on stomata closing in plants, nitric oxide (NO) has an influence on seed dormancy, flower development, root gravitropism, gene expression, plant defence reactions in pathoge... Read More about H2S and NO signalling in plants.

Detection of thiol modifications by hydrogen sulfide (2015)
Book Chapter
Williams, E., Pead, S., Whiteman, M., Wood, M. E., Wilson, I. D., Ladomery, M., …Hancock, J. T. (2015). Detection of thiol modifications by hydrogen sulfide. In E. Cadenas, & L. Packer (Eds.), Hydrogen Sulfide in Redox Biology Part B (233-251). UK: Academic Press

The evolutionarily conserved multifunctional glycine-rich RNA-binding proteins play key roles in development and stress adaptation (2015)
Journal Article
Wilson, I., Ciuzan, O., Hancock, J. T., Pamfil, D., Wilson, I. D., & Ladomery, M. (2015). The evolutionarily conserved multifunctional glycine-rich RNA-binding proteins play key roles in development and stress adaptation. Physiologia Plantarum, 153(1), 1-11. https://doi.org/10.1111/ppl.12286

© 2014 Scandinavian Plant Physiology Society. The class IV glycine-rich RNA-binding proteins are a distinct subgroup within the heterogenous superfamily of glycine-rich proteins (GRPs). They are distinguished by the presence of an RNA-binding domain... Read More about The evolutionarily conserved multifunctional glycine-rich RNA-binding proteins play key roles in development and stress adaptation.

Hydrogen sulfide and cell signaling: Team player or referee? (2014)
Journal Article
Hancock, J. T., Hancock, J. T., & Whiteman, M. (2014). Hydrogen sulfide and cell signaling: Team player or referee?. Plant Physiology and Biochemistry, 78, 37-42. https://doi.org/10.1016/j.plaphy.2014.02.012

Hydrogen sulfide (H2S) has been postulated to be the third gasotransmitter, and along with other reactive compounds such as reactive oxygen species (ROS) and nitric oxide (NO) it is thought to be a key signalling molecule. Enzymes which generate H2S,... Read More about Hydrogen sulfide and cell signaling: Team player or referee?.

Electrochemical detection of extracellular hydrogen peroxide in Arabidopsis thaliana: A real-time marker of oxidative stress (2013)
Journal Article
Killard, A. J., Hancock, J., Valero, E., Pérez-Prior, M. T., González-Macia, L., González-Sánchez, M. I., …Killard, A. (2013). Electrochemical detection of extracellular hydrogen peroxide in Arabidopsis thaliana: A real-time marker of oxidative stress. Plant, Cell and Environment, 36(4), 869-878. https://doi.org/10.1111/pce.12023

An electrochemical approach to directly measure the dynamic process of H2O2 release from cultures of Arabidopsis thaliana cells is reported. This approach is based on H2O2 oxidation on a Pt electrode in conjunction with continuous measurement of samp... Read More about Electrochemical detection of extracellular hydrogen peroxide in Arabidopsis thaliana: A real-time marker of oxidative stress.

Hydrogen sulfide: Environmental factor or signalling molecule? (2013)
Journal Article
Lisjak, M., Lisjak, M., Teklic, T., Wilson, I. D., Whiteman, M., & Hancock, J. T. (2013). Hydrogen sulfide: Environmental factor or signalling molecule?. Plant, Cell and Environment, 36(9), 1607-1616. https://doi.org/10.1111/pce.12073

Hydrogen sulfide (H2S) has traditionally been thought of as a phytotoxin, having deleterious effects on the plant growth and survival. It is now recognized that plants have enzymes which generate H2S, cysteine desulfhydrase, and remove it, O-acetylse... Read More about Hydrogen sulfide: Environmental factor or signalling molecule?.

Low dose ionizing radiation produces too few reactive oxygen species to directly affect antioxidant concentrations in cells (2012)
Journal Article
Smith, J. T., Willey, N., & Hancock, J. T. (2012). Low dose ionizing radiation produces too few reactive oxygen species to directly affect antioxidant concentrations in cells. Biology Letters, 8(4), 594-597. https://doi.org/10.1098/rsbl.2012.0150

It has been hypothesized that radiation-induced oxidative stress is the mechanism for a wide range of negative impacts on biota living in radioactively contaminated areas around Chernobyl. The present study tests this hypothesis mechanistically, for... Read More about Low dose ionizing radiation produces too few reactive oxygen species to directly affect antioxidant concentrations in cells.

Differential redox potential between the human cytosolic and mitochondrial branched-chain aminotransferase (2012)
Journal Article
Coles, S. J., Hancock, J. T., & Conway, M. E. (2012). Differential redox potential between the human cytosolic and mitochondrial branched-chain aminotransferase. Acta Biochimica et Biophysica Sinica, 44(2), 172-176. https://doi.org/10.1093/abbs/gmr103

The human branched-chain aminotransferase (hBCAT) isoenzymes are CXXC motif redox sensitive homodimers central to glutamate metabolism in the central nervous system. These proteins respond differently to oxidation by H 2O 2, NO, and S-glutathionylati... Read More about Differential redox potential between the human cytosolic and mitochondrial branched-chain aminotransferase.

In planta conditions induce genomic changes in Pseudomonas syringae pv. phaseolicola (2011)
Journal Article
Godfrey, S. A., Lovell, H. C., Jackson, R. W., Mansfield, J. W., Hancock, J. T., Desikan, R., & Arnold, D. L. (2011). In planta conditions induce genomic changes in Pseudomonas syringae pv. phaseolicola. Molecular Plant Pathology, 12(2), 167-176. https://doi.org/10.1111/j.1364-3703.2010.00658.x

The co-evolution of bacterial plant pathogens and their hosts is a complex and dynamic process. Plant resistance can impose stress on invading pathogens that can lead to, and select for, beneficial changes in the bacterial genome. The Pseudomonas syr... Read More about In planta conditions induce genomic changes in Pseudomonas syringae pv. phaseolicola.

The relationship of proline content and metabolism on the productivity of maize plants (2011)
Journal Article
Teklić, T., Agić, D., Špoljarević, M., Lisjak, M., Gumze, A., Wilson, I. D., & Hancock, J. T. (2011). The relationship of proline content and metabolism on the productivity of maize plants. Plant Signaling and Behavior, 6(2), 251-257. https://doi.org/10.4161/psb.6.2.14336

The free proline content in maize ear-leaves, silk and pollen were analyzed in field grown plants which had matured to the pollination stage. Using maize hybrids PR34F02, PR35P12 and PR36B08 field trials were set up at two locations in eastern croati... Read More about The relationship of proline content and metabolism on the productivity of maize plants.

Translationally controlled tumour protein (TCTP) is a novel glucose-regulated protein that is important for survival of pancreatic beta cells (2011)
Journal Article
Avent, N. D., Bommer, U. A., Diraison, F., Hayward, K., Sanders, K. L., Brozzi, F., …Varadi, A. (2011). Translationally controlled tumour protein (TCTP) is a novel glucose-regulated protein that is important for survival of pancreatic beta cells. Diabetologia, 54(2), 368-379. https://doi.org/10.1007/s00125-010-1958-7

Aims/hypothesis: This study used proteomics and biochemical approaches to identify novel glucose-regulated proteins and to unveil their role in pancreatic beta cell function. Translationally controlled tumour protein (TCTP) was identified to be one s... Read More about Translationally controlled tumour protein (TCTP) is a novel glucose-regulated protein that is important for survival of pancreatic beta cells.

Nitric oxide and ABA in the control of plant function (2011)
Journal Article
Hancock, J. T., Neill, S., & Wilson, I. D. (2011). Nitric oxide and ABA in the control of plant function. Plant Science, 181(5), 555-559. https://doi.org/10.1016/j.plantsci.2011.03.017

Abscisic acid (ABA) and nitric oxide (NO) are both extremely important signalling molecules employed by plants to control many aspects of physiology. ABA has been extensively studied in the mechanisms which control stomatal movement as well as in see... Read More about Nitric oxide and ABA in the control of plant function.

Hydrogen sulfide effects on stomatal apertures (2011)
Journal Article
Lisjak, M., Teklic, T., Wilson, I. D., Wood, M., Whiteman, M., & Hancock, J. T. (2011). Hydrogen sulfide effects on stomatal apertures. Plant Signaling and Behavior, 6(10), 1444-1446

A novel hydrogen sulfide donor causes stomatal opening and reduces nitric oxide accumulation (2010)
Journal Article
Lisjak, M., Srivastava, N., Teklic, T., Civale, L., Lewandowski, K., Wilson, I. D., …Hancock, J. T. (2010). A novel hydrogen sulfide donor causes stomatal opening and reduces nitric oxide accumulation. Plant Physiology and Biochemistry, 48(12), 931-935. https://doi.org/10.1016/j.plaphy.2010.09.016

Effects of hydrogen sulfide (H2S) on plant physiology have been previously studied, but such studies have relied on the use of NaSH as a method for supplying H2S to tissues. Now new compounds which give a less severe H2S shock and a more prolonged ex... Read More about A novel hydrogen sulfide donor causes stomatal opening and reduces nitric oxide accumulation.

Assessment of the influence of different sample processing and cold storage duration on plant free proline content analyses (2010)
Journal Article
Andrić, L., ParadIković, N., Stanisavljević, A., ŠPoljarević, M., Teklić, T., Lisjak, M., …Hancock, J. T. (2010). Assessment of the influence of different sample processing and cold storage duration on plant free proline content analyses. Phytochemical Analysis, 21(6), 561-565. https://doi.org/10.1002/pca.1233

Introduction - A method which is widely accepted for the analysis of free proline content in plant tissues is based on the use of 3% sulfosalicylic acid as an extractant, followed by spectrophotometric quantification of a proline-ninhydrin complex in... Read More about Assessment of the influence of different sample processing and cold storage duration on plant free proline content analyses.

Cell signalling (2010)
Book
Hancock, J. T. (2010). Cell signalling. Oxford University Press

A proteomic analysis of oligo(dT)-bound mRNP containing oxidative stress-induced Arabidopsis thaliana RNA-binding proteins ATGRP7 and ATGRP8 (2010)
Journal Article
Schmidt, F., Marnef, A., Cheung, M. K., Wilson, I. D., Hancock, J. T., Staiger, D., & Ladomery, M. (2010). A proteomic analysis of oligo(dT)-bound mRNP containing oxidative stress-induced Arabidopsis thaliana RNA-binding proteins ATGRP7 and ATGRP8. Molecular Biology Reports, 37(2), 839-845. https://doi.org/10.1007/s11033-009-9636-x

Plants are highly adapted to respond to a range of environmental stresses commonly by altering their gene expression and metabolism as a result of cell signalling which may be mediated by reactive oxygen species. The glycine-rich RNA-binding proteins... Read More about A proteomic analysis of oligo(dT)-bound mRNP containing oxidative stress-induced Arabidopsis thaliana RNA-binding proteins ATGRP7 and ATGRP8.

The role of redox mechanisms in cell signalling (2009)
Journal Article
Hancock, J. T. (2009). The role of redox mechanisms in cell signalling. Molecular Biotechnology, 43(2), 162-166. https://doi.org/10.1007/s12033-009-9189-1

Functioning and efficient cell signalling is vital for the survival of cells. Over the years various components have been identified and recognised as crucial for the transduction of signals in cells. Many of the mechanisms allow for a relatively rap... Read More about The role of redox mechanisms in cell signalling.

Bacterial Evolution by Genomic Island Transfer Occurs via DNA Transformation In Planta (2009)
Journal Article
Godfrey, S. A. C., Lovell, H. C., Mansfield, J. W., Jackson, R. W., Hancock, J. T., & Arnold, D. L. (2009). Bacterial Evolution by Genomic Island Transfer Occurs via DNA Transformation In Planta. Current Biology, 19(18), 1586-1590. https://doi.org/10.1016/j.cub.2009.08.018

Our understanding of the evolution of microbial pathogens has been advanced by the discovery of "islands" of DNA that differ from core genomes and contain determinants of virulence [1, 2]. The acquisition of genomic islands (GIs) by horizontal gene t... Read More about Bacterial Evolution by Genomic Island Transfer Occurs via DNA Transformation In Planta.

Reactive oxygen species, nitric oxide and signal crosstalk (2009)
Book Chapter
Neill, S., Hancock, J. T., & Wilson, I. D. (2009). Reactive oxygen species, nitric oxide and signal crosstalk. In K. Yoshioka, & K. Shinozaki (Eds.), Signal Crosstalk in Plant Stress Responses (136-160). Iowa: Wiley-Blackwell

The effects of glucose ingestion and glucose regulation on memory performance in older adults with mild cognitive impairment (2009)
Journal Article
Hancock, J., Riby, L., Marriott, A., Bullock, R., Hancock, J., Smallwood, J., & McLaughlin, J. (2009). The effects of glucose ingestion and glucose regulation on memory performance in older adults with mild cognitive impairment. European Journal of Clinical Nutrition, 63(4), 566-571. https://doi.org/10.1038/sj.ejcn.1602981

Background/Objectives: Previous research investigating the impact of glucose ingestion and/or improvements in glucose regulation has found selective cognitive facilitation on episodic memory tasks in successful ageing and dementia. The present study... Read More about The effects of glucose ingestion and glucose regulation on memory performance in older adults with mild cognitive impairment.

S-Nitrosoglutathione inactivation of the mitochondrial and cytosolic BCAT proteins: S-nitrosation and S-thiolation (2009)
Journal Article
Coles, S. J., Easton, P., Sharrod, H., Hutson, S. M., Hancock, J. T., Patel, V., & Conway, M. E. (2009). S-Nitrosoglutathione inactivation of the mitochondrial and cytosolic BCAT proteins: S-nitrosation and S-thiolation. Biochemistry, 48(3), 645-656. https://doi.org/10.1021/bi801805h

Specific proteins with reactive thiol(ate) groups are susceptible to nitric oxide (NO) modification, which can result in S-nitrosation, S-thiolation, or disulfide bond formation. In the present study the effect of NO modification on the functionality... Read More about S-Nitrosoglutathione inactivation of the mitochondrial and cytosolic BCAT proteins: S-nitrosation and S-thiolation.

S-nitrosoglutathione inactivation of the mitochondrial and cytosolic BCAT proteins: S-nitrosation and s-thiolation (2009)
Journal Article
Coles, S. J., Easton, P., Sharrod, H., Hutson, S. M., Hancock, J. T., Patel, V. B., & Conway, M. E. (2009). S-nitrosoglutathione inactivation of the mitochondrial and cytosolic BCAT proteins: S-nitrosation and s-thiolation. Biochemistry, 48(3), 645-656. https://doi.org/10.1021/bi801805h

Specific proteins with reactive thiol(ate) groups are susceptible to nitric oxide (NO) modification, which can result in S-nitrosation, S-thiolation, or disulfide bond formation. In the present study the effect of NO modification on the functionality... Read More about S-nitrosoglutathione inactivation of the mitochondrial and cytosolic BCAT proteins: S-nitrosation and s-thiolation.

Pollen generates nitric oxide and nitrite: a possible link to pollen-induced allergic responses (2009)
Journal Article
Bright, J., Hiscock, S. J., James, P. E., & Hancock, J. T. (2009). Pollen generates nitric oxide and nitrite: a possible link to pollen-induced allergic responses. Plant Physiology and Biochemistry, 47(1), 49-55. https://doi.org/10.1016/j.plaphy.2008.09.005

Reactive nitrogen species (RNS), such as nitric oxide (NO), are ubiquitous and diverse signalling molecules involved in a wide range of physiological and pathophysiological processes in both animals and plants. Nitrite, a metabolite of NO turnover, h... Read More about Pollen generates nitric oxide and nitrite: a possible link to pollen-induced allergic responses.

Tools to investigate reaction oxygen species-sensitive signaling proteins (2009)
Book Chapter
Desikan, R., Neill, S., Slinn, J., & Hancock, J. T. (2009). Tools to investigate reaction oxygen species-sensitive signaling proteins. In J. T. Hancock (Ed.), Redox-Mediated Signal Transduction (84-96). Humana Press. https://doi.org/10.1007/978-1-59745-129-1_7

The thiols groups of cysteine residues on proteins are attractive oxidative targets for modification by reactive oxygen species, such as hydrogen peroxide (H2O2). Such modification can lead to important cellular signaling processes that ultimately re... Read More about Tools to investigate reaction oxygen species-sensitive signaling proteins.

Cell signalling is the music of life (2009)
Journal Article
Hancock, J. T. (2009). Cell signalling is the music of life. British Journal of Biomedical Science, 65, 205-208

Cell signalling is an immensely important topic in biological and biomedical sciences, and one which has an ever-increasing literature. As more and more is known about it, and more components are discovered, it is getting harder and harder to visuali... Read More about Cell signalling is the music of life.

Lipid peroxidation levels in soybean (Glycine max (L.) Merr.) seed parts as a consequence on imbibition stress (2009)
Journal Article
Lisjak, M., Wilson, I. D., Civale, L., Hancock, J. T., & Teklic, T. (2009). Lipid peroxidation levels in soybean (Glycine max (L.) Merr.) seed parts as a consequence on imbibition stress. Agriculture, 15, 32-37

High rainfall and rapid water uptake by dry seed after sowing in the field can result in so-called seed imbibitional damage. Here, lipid peroxidation levels were evaluated in seed testa, embryos and cotyledons of three soybean cultivars (Podravka 95,... Read More about Lipid peroxidation levels in soybean (Glycine max (L.) Merr.) seed parts as a consequence on imbibition stress.

Differential requirement for NO during ABA-induced stomatal closure in turgid and wilted leaves (2009)
Journal Article
Harrison, J., Ribeiro, D. M., Desikan, R., Bright, J., Confraria, A., Hancock, J. T., …Wilson, I. D. (2009). Differential requirement for NO during ABA-induced stomatal closure in turgid and wilted leaves. Plant, Cell and Environment, 32(1), 46-57. https://doi.org/10.1111/j.1365-3040.2008.01906.x

Abscisic acid (ABA)-induced stomatal closure is mediated by a complex, guard cell signalling network involving nitric oxide (NO) as a key intermediate. However, there is a lack of information concerning the role of NO in the ABA-enhanced stomatal clo... Read More about Differential requirement for NO during ABA-induced stomatal closure in turgid and wilted leaves.

Role of nitric oxide in regulating stomatal apertures (2009)
Journal Article
Wilson, I. D., Ribeiro, D. M., Bright, J., Confraria, A., Harrison, J., Barros, R. S., …Hancock, J. T. (2009). Role of nitric oxide in regulating stomatal apertures. Plant Signaling and Behavior, 4(5), 467-469. https://doi.org/10.4161/psb.4.5.8545

During stomatal closure, nitric oxide (NO) operates as one of the key intermediates in the complex, abscisic acid (ABA)-mediated, guard cell signaling network that regulates this process. However, data concerning the role of NO in stomatal closure th... Read More about Role of nitric oxide in regulating stomatal apertures.

The role of redox in signal transduction (2008)
Book Chapter
Hancock, J. T. (2008). The role of redox in signal transduction. In J. T. Hancock (Ed.), Redox-Mediated Signal Transduction: Methods and Protocols (1-9). Humana Press

The histidine kinase AHK5 integrates endogenous and environmental signals in Arabidopsis guard cells (2008)
Journal Article
Desikan, R., Horák, J., Chaban, C., Mira-Rodado, V., Witthöft, J., Elgass, K., …Harter, K. (2008). The histidine kinase AHK5 integrates endogenous and environmental signals in Arabidopsis guard cells. PLoS ONE, 3(6), 1-15. https://doi.org/10.1371/journal.pone.0002491

Background: Stomatal guard cells monitor and respond to environmental and endogenous signals such that the stomatal aperture is continually optimised for water use efficiency. A key signalling molecule produced in guard cells in response to plant hor... Read More about The histidine kinase AHK5 integrates endogenous and environmental signals in Arabidopsis guard cells.

Tools to investigate ROS sensitive signalling proteins (2008)
Journal Article
Desikan, R., Neill, S., Slinn, J., & Hancock, J. T. (2008). Tools to investigate ROS sensitive signalling proteins. Methods in Molecular Biology, 476, 87-99. https://doi.org/10.1007/978-1-59745-129-1_7

The thiols groups of cysteine residues on proteins are attractive oxidative targets for modification by reactive oxygen species, such as hydrogen peroxide (H2O2). Such modification can lead to important cellular signaling processes that ultimately re... Read More about Tools to investigate ROS sensitive signalling proteins.

Nitric oxide, stomatal closure, and abiotic stress (2008)
Journal Article
Ribeiro, D., Harrison, J., Neill, S., Barros, R. S., Bright, J., Desikan, R., …Wilson, I. D. (2008). Nitric oxide, stomatal closure, and abiotic stress. Journal of Experimental Botany, 59(2), 165-176. https://doi.org/10.1093/jxb/erm293

Various data indicate that nitric oxide (NO) is an endogenous signal in plants that mediates responses to several stimuli. Experimental evidence in support of such signalling roles for NO has been obtained via the application of NO, usually in the fo... Read More about Nitric oxide, stomatal closure, and abiotic stress.

Nitric oxide evolution and perception (2008)
Journal Article
Harrison, J., Neill, S., Bright, J., Desikan, R., Hancock, J. T., & Wilson, I. D. (2008). Nitric oxide evolution and perception. Journal of Experimental Botany, 59(1), 25-35. https://doi.org/10.1093/jxb/erm218

Various experimental data indicate signalling roles for nitric oxide (NO) in processes such as xylogenesis, programmed cell death, pathogen defence, flowering, stomatal closure, and gravitropism. However, it still remains unclear how NO is synthesize... Read More about Nitric oxide evolution and perception.

Antioxidative responses in radish (Raphanus sativus L.) plants stressed by copper and lead in nutrient solution and soil (2008)
Journal Article
Teklic, T., Hancock, J. T., Engler, M., Paradikovic, N., Cesar, V., Lepeduš, H., …Bešlo, D. (2008). Antioxidative responses in radish (Raphanus sativus L.) plants stressed by copper and lead in nutrient solution and soil. Acta Biologica Cracoviensia Series Botanica, 50(2), 79-86

Radish (Raphanus sativus L.) is commonly grown in urban and suburban areas where the soil may be polluted with heavy metals such as Cu or Pb. In this study, short exposure of radish plantlets to 0.5 mM Cu or Pb in nutrient solution (two days) in grow... Read More about Antioxidative responses in radish (Raphanus sativus L.) plants stressed by copper and lead in nutrient solution and soil.

Nitric oxide signalling in plants (2008)
Journal Article
Wilson, I. D., Neill, S., & Hancock, J. T. (2008). Nitric oxide signalling in plants. Plant, Cell and Environment, 31(5), 622-631. https://doi.org/10.1111/j.1365-3040.2007.01761.x

As with all organisms, plants must respond to a plethora of external environmental cues. Individual plant cells must also perceive and respond to a wide range of internal signals. It is now well-accepted that nitric oxide (NO) is a component of the r... Read More about Nitric oxide signalling in plants.

Nitric oxide synthesis and signalling in plants (2008)
Journal Article
Neill, S. J., Wilson, I. D., & Hancock, J. T. (2008). Nitric oxide synthesis and signalling in plants. Plant, Cell and Environment, 31(5), 622-631. https://doi.org/10.1111/j.1365-3040.2007.01761.x

As with all organisms, plants must respond to a plethora of external environmental cues. Individual plant cells must also perceive and respond to a wide range of internal signals. It is now well-accepted that nitric oxide (NO) is a component of the r... Read More about Nitric oxide synthesis and signalling in plants.

Implications of dealing with airborne substances and reactive oxygen species: What mammalian lungs, animals, and plants have to say (2007)
Journal Article
Filho, D. W., Hermes-Lima, M., Oliveira, E. S., Spinelli de Oliveira, E., Hancock, J. T., Isola, D. A., …Wilhelm Filho, D. (2007). Implications of dealing with airborne substances and reactive oxygen species: What mammalian lungs, animals, and plants have to say. Integrative and Comparative Biology, 47(4), 578-591. https://doi.org/10.1093/icb/icm078

A gas-exchange structure interacts with the environment and is constantly challenged by contaminants that may elicit defense responses, thus compromising its primary function. It is also exposed to high concentrations of O2 that can generate reactive... Read More about Implications of dealing with airborne substances and reactive oxygen species: What mammalian lungs, animals, and plants have to say.

Nitric oxide, stomatal closure and abiotic stress (2007)
Journal Article
Neill, S., Barros, R. S., Bright, J., Desikan, R., Hancock, J. T., Harrison, J., …Ribeiro, D. M. (2007). Nitric oxide, stomatal closure and abiotic stress. Comparative Biochemistry and Physiology - Part A: Molecular and Integrative Physiology, 146(4), S257. https://doi.org/10.1016/j.cbpa.2007.01.648

Various data indicate that nitric oxide (NO) is an endogenous signal in plants that mediates responses to several stimuli. Experimental evidence in support of such signalling roles for NO has been obtained via the application of NO (usually in the fo... Read More about Nitric oxide, stomatal closure and abiotic stress.

Signaling on the stigma: Potential new roles for ROS and NO in plant cell signaling (2007)
Journal Article
Hiscock, S. J., Bright, J., McInnis, S. M., Desikan, R., & Hancock, J. T. (2007). Signaling on the stigma: Potential new roles for ROS and NO in plant cell signaling. Plant Signaling and Behavior, 2(1), 23-24

Reactive oxygen species (ROS) and reactive nitrogen species, particularly NO, are key components of diverse signaling networks in animals and plants. We have recently shown that epidermal cells of stigmas from a range of different angiosperms accumul... Read More about Signaling on the stigma: Potential new roles for ROS and NO in plant cell signaling.

Production of reactive oxygen species and reactive nitrogen species by angiosperm stigmas and pollen: Potential signalling crosstalk? (2006)
Journal Article
McInnis, S. M., Desikan, R., Hancock, J. T., & Hiscock, S. J. (2006). Production of reactive oxygen species and reactive nitrogen species by angiosperm stigmas and pollen: Potential signalling crosstalk?. New Phytologist, 172(2), 221-228. https://doi.org/10.1111/j.1469-8137.2006.01875.x

• Angiosperm stigmas exhibit high levels of peroxidase activity when receptive to pollen. To explore possible function(s) of this peroxidase activity we investigated amounts of reactive oxygen species (ROS), particularly hydrogen peroxide, in stigmas... Read More about Production of reactive oxygen species and reactive nitrogen species by angiosperm stigmas and pollen: Potential signalling crosstalk?.

Ethylene-induced stomatal closure in Arabidopsis occurs via AtrbohF-mediated hydrogen peroxide synthesis (2006)
Journal Article
Desikan, R., Last, K., Harrett-Williams, R., Tagliavia, C., Harter, K., Hooley, R., …Neill, S. (2006). Ethylene-induced stomatal closure in Arabidopsis occurs via AtrbohF-mediated hydrogen peroxide synthesis. Plant Journal, 47(6), 907-916. https://doi.org/10.1111/j.1365-313X.2006.02842.x

Ethylene is a plant hormone that regulates many aspects of growth and development. Despite the well-known association between ethylene and stress signalling, its effects on stomatal movements are largely unexplored. Here, genetic and physiological da... Read More about Ethylene-induced stomatal closure in Arabidopsis occurs via AtrbohF-mediated hydrogen peroxide synthesis.

Doing the unexpected: Proteins involved in hydrogen peroxide perception (2006)
Journal Article
Harrison, J., Hancock, J., Desikan, R., Bright, J., Hooley, R., & Neill, S. (2006). Doing the unexpected: Proteins involved in hydrogen peroxide perception. Journal of Experimental Botany, 57(8), 1711-1718. https://doi.org/10.1093/jxb/erj180

A look back at the early literature on reactive oxygen species (ROS) gives the impression that these small inorganic molecules had a singular defined role, that of host defence in mammalian systems. However, it is now known that their roles also incl... Read More about Doing the unexpected: Proteins involved in hydrogen peroxide perception.

The role of stigma peroxidases in flowering plants: Insights from further characterization of a stigma-specific peroxidase (SSP) from Senecio squalidus (Asteraceae) (2006)
Journal Article
Porter, R., McInnis, S. M., Emery, D. C., Desikan, R., Hancock, J. T., & Hiscock, S. J. (2006). The role of stigma peroxidases in flowering plants: Insights from further characterization of a stigma-specific peroxidase (SSP) from Senecio squalidus (Asteraceae). Journal of Experimental Botany, 57(8), 1835-1846. https://doi.org/10.1093/jxb/erj182

Angiosperm stigmas have long been known to exhibit high levels of peroxidase activity when they are mature and most receptive to pollen but the biological function of stigma peroxidases is not known. A novel stigma-specific class III peroxidase gene,... Read More about The role of stigma peroxidases in flowering plants: Insights from further characterization of a stigma-specific peroxidase (SSP) from Senecio squalidus (Asteraceae).

ABA-induced NO generation and stomatal closure in Arabidopsis are dependent on H2O2 synthesis (2006)
Journal Article
Bright, J., Desikan, R., Hancock, J. T., Weir, I. S., & Neill, S. (2006). ABA-induced NO generation and stomatal closure in Arabidopsis are dependent on H2O2 synthesis. Plant Journal, 45(1), 113-122. https://doi.org/10.1111/j.1365-313X.2005.02615.x

Nitric oxide (NO) and hydrogen peroxide (H2O2) are key signalling molecules produced in response to various stimuli and involved in a diverse range of plant signal transduction processes. Nitric oxide and H 2O2 have been identified as essential compo... Read More about ABA-induced NO generation and stomatal closure in Arabidopsis are dependent on H2O2 synthesis.

Proteomic identification of glyceraldehyde 3-phosphate dehydrogenase as an inhibitory target of hydrogen peroxide in Arabidopsis (2005)
Journal Article
Harrison, J., Hancock, J. T., Henson, D., Nyirenda, M., Desikan, R., Lewis, M., …Neill, S. (2005). Proteomic identification of glyceraldehyde 3-phosphate dehydrogenase as an inhibitory target of hydrogen peroxide in Arabidopsis. Plant Physiology and Biochemistry, 43(9), 828-835. https://doi.org/10.1016/j.plaphy.2005.07.012

Hydrogen peroxide (H2O2) is now recognised as a key signalling molecule in eukaryotes. In plants, H2O2 is involved in regulating stomatal closure, gravitropic responses, gene expression and programmed cell death. Although several kinases, such as oxi... Read More about Proteomic identification of glyceraldehyde 3-phosphate dehydrogenase as an inhibitory target of hydrogen peroxide in Arabidopsis.

Reactive oxygen species as signalling molecules (2005)
Book Chapter
Desikan, R., Hancock, J. T., & Neill, S. (2005). Reactive oxygen species as signalling molecules. In N. Smirnoff (Ed.), Antioxidants and Reactive Oxygen Species in Plants. Wiley

Recording forces exerted on the bowel wall during colonoscopy: in vitro evaluation. (2005)
Journal Article
Dogramadzi, S., Virk, G. S., Bell, G. D., Rowland, R. S., & Hancock, J. (2005). Recording forces exerted on the bowel wall during colonoscopy: in vitro evaluation. International Journal of Medical Robotics and Computer Assisted Surgery, 1(4), 89-97. https://doi.org/10.1002/rcs.61

A novel system for distributed force measurement between the bowel wall and the shaft of a colonoscope is presented. The system, based on the piezoresistive method, involves the integration of soft miniature transducers to a colonoscope to enable a w... Read More about Recording forces exerted on the bowel wall during colonoscopy: in vitro evaluation..

DNA microarray screening of differential gene expression in bone marrow samples from AML, non-AML patients and AML cell lines (2004)
Journal Article
Gray, A. G., Morgan, L. M., Avent, N. D., Smith, M. A., Court, E. L., Hancock, J. T., & Smith, J. G. (2004). DNA microarray screening of differential gene expression in bone marrow samples from AML, non-AML patients and AML cell lines. Leukemia Research, 28(7), 743-753. https://doi.org/10.1016/j.leukres.2003.11.011

This study used cDNA microarray technology to compare gene expression profiles in acute myeloblastic leukaemia (AML) with cDNA dot-blot and real time PCR analysis of cDNA transcripts to confirm array data. Patient AML marrow samples and AML cell line... Read More about DNA microarray screening of differential gene expression in bone marrow samples from AML, non-AML patients and AML cell lines.

New equations for redox and nano-signal transduction (2004)
Journal Article
Hancock, J. T., Desikan, R., Neill, S., & Cross, A. R. (2004). New equations for redox and nano-signal transduction. Journal of Theoretical Biology, 226(1), 65-68. https://doi.org/10.1016/j.jtbi.2003.08.003

Cells maintain redox potentials (Eh) in intracellular compartments, sometimes referred to as redox environments. These potentials are often very reducing, for example in the cytoplasm, but throughout the cell different potentials are maintained, comm... Read More about New equations for redox and nano-signal transduction.

ABA, hydrogen peroxide and nitric oxide signalling in stomatal guard cells (2004)
Journal Article
Desikan, R., Cheung, M., Bright, J., Henson, D., Hancock, J. T., & Neill, S. (2004). ABA, hydrogen peroxide and nitric oxide signalling in stomatal guard cells. Journal of Experimental Botany, 55(395), 205-212

Increased synthesis and redistribution of the phytohormone abscisic acid (ABA) in response to water deficit stress initiates an intricate network of signalling pathways in guard cells leading to stomatal closure. Despite the large number of ABA signa... Read More about ABA, hydrogen peroxide and nitric oxide signalling in stomatal guard cells.

Hydrogen peroxide is a common signal for darkness and ABA-induced stomatal closure in Pisum sativum L. (2004)
Journal Article
Desikan, R., Cheung, M., Clarke, A., Golding, S., Sagi, M., Fluhr, R., …Neill, S. (2004). Hydrogen peroxide is a common signal for darkness and ABA-induced stomatal closure in Pisum sativum L. Functional Plant Biology, 31(9), 913-920

The requirement for hydrogen peroxide (H2O2) generation and action during stomatal closure induced by darkness and abscisic acid (ABA) was investigated in pea (Pisum sativum L.). Stomatal closure induced by darkness or ABA was inhibited by the H2O2-s... Read More about Hydrogen peroxide is a common signal for darkness and ABA-induced stomatal closure in Pisum sativum L..

Oxidative stress signalling (2003)
Book Chapter
Desikan, R., Hancock, J. T., & Neill, S. (2003). Oxidative stress signalling. In H. Hirt, & K. Shinozaki (Eds.), Plant Responses to Abiotic Stress (121-150). Springer-Verlag

Principles of cell signalling (2003)
Book Chapter
Hancock, J. T. (2003). Principles of cell signalling. In S. Kumar, & P. Bentley (Eds.), On Growth, Form and Computers. Elsevier

Nitric oxide signalling in plants (2003)
Journal Article
Neill, S., Desikan, R., & Hancock, J. T. (2003). Nitric oxide signalling in plants. New Phytologist, 159(1), 11-35. https://doi.org/10.1046/j.1469-8137.2003.00804.x

Recently nitric oxide (NO) has emerged as a key signalling molecule in plants. Here we review the potential sources of endogenous NO, outline the biological processes likely to be mediated by NO, and discuss the downstream signalling processes by whi... Read More about Nitric oxide signalling in plants.

Cytochrome c, Glutathione, and the Possible Role of Redox Potentials in Apoptosis (2003)
Journal Article
Neill, S. J., Hancock, J. T., & Desikan, R. (2003). Cytochrome c, Glutathione, and the Possible Role of Redox Potentials in Apoptosis. Annals of the New York Academy of Sciences, 1010(Apopto), 446-448. https://doi.org/10.1196/annals.1299.081

The redox environment of the cell is now thought to be extremely important to control the activity of many proteins. During apoptosis, the intracellular redox potential (Eh) becomes more positive, with possible consequences for the mechanisms of apop... Read More about Cytochrome c, Glutathione, and the Possible Role of Redox Potentials in Apoptosis.

A new role for an old enzyme: Nitrate reductase-mediated nitric oxide generation is required for abscisic acid-induced stomatal closure in Arabidopsis thaliana (2002)
Journal Article
Desikan, R., Griffiths, R., Hancock, J. T., & Neill, S. (2002). A new role for an old enzyme: Nitrate reductase-mediated nitric oxide generation is required for abscisic acid-induced stomatal closure in Arabidopsis thaliana. Proceedings of the National Academy of Sciences, 99(25), 16314-16318. https://doi.org/10.1073/pnas.252461999

The plant hormone abscisic acid (ABA), synthesized in response to water-deficit stress, induces stomatal closure via activation of complex signaling cascades. Recent work has established that nitric oxide (NO) is a key signaling molecule mediating AB... Read More about A new role for an old enzyme: Nitrate reductase-mediated nitric oxide generation is required for abscisic acid-induced stomatal closure in Arabidopsis thaliana.

Antimicrobial properties of milk: Dependence on presence of xanthine oxidase and nitrite (2002)
Journal Article
Hancock, J. T., Salisbury, V., Ovejero-Boglione, M. C., Cherry, R., Hoare, C., Eisenthal, R., & Harrison, R. (2002). Antimicrobial properties of milk: Dependence on presence of xanthine oxidase and nitrite. Antimicrobial Agents and Chemotherapy, 46(10), 3308-3310. https://doi.org/10.1128/AAC.46.10.3308-3310.2002

Human and bovine milk inhibited the metabolic activity of Escherichia coli, as shown by luminescence monitoring of constructs expressing the luxCDABE genes. Inhibition was dependent on both xanthine oxidase (XO) activity and on the presence of nitrit... Read More about Antimicrobial properties of milk: Dependence on presence of xanthine oxidase and nitrite.

Cell signalling following plant/pathogen interactions involves the generation of reactive oxygen and reactive nitrogen species (2002)
Journal Article
Hancock, J. T., Desikan, R., Clarke, A., Hurst, R. D., & Neill, S. (2002). Cell signalling following plant/pathogen interactions involves the generation of reactive oxygen and reactive nitrogen species. Plant Physiology and Biochemistry, 40(6-8), 611-617. https://doi.org/10.1016/S0981-9428%2802%2901403-1

It is now clear that reactive oxygen species (ROS), such as hydrogen peroxide (H2O2), and reactive nitrogen species, such as nitric oxide (NO), are produced by plant cells in response to a variety of stresses, including pathogen challenge. Such molec... Read More about Cell signalling following plant/pathogen interactions involves the generation of reactive oxygen and reactive nitrogen species.

Hydrogen peroxide and nitric oxide as signalling molecules in plants (2002)
Journal Article
Neill, S., Desikan, R., Clarke, A., Hurst, R. D., & Hancock, J. T. (2002). Hydrogen peroxide and nitric oxide as signalling molecules in plants. Journal of Experimental Botany, 53(372), 1237-1247

It is now clear that hydrogen peroxide (H2O2) and nitric oxide (NO) function as signalling molecules in plants. A wide range of abiotic and biotic stresses results in H2O2 generation, from a variety of sources. H2O2 is removed from cells via a number... Read More about Hydrogen peroxide and nitric oxide as signalling molecules in plants.

Hydrogen peroxide signalling (2002)
Journal Article
Neill, S., Desikan, R., & Hancock, J. T. (2002). Hydrogen peroxide signalling. Current Opinion in Plant Biology, 5(5), 388-395

Regulation of the Arabidopsis transcriptome by oxidative stress (2001)
Journal Article
Neill, S. J., Hancock, J. T., A.-H.-Mackerness, S., Desikan, R., Desikan, R., Mackerness, S., …Neill, S. (2001). Regulation of the Arabidopsis transcriptome by oxidative stress. Plant Physiology, 127(1), 159-172. https://doi.org/10.1104/pp.127.1.159

Oxidative stress, resulting from an imbalance in the accumulation and removal of reactive oxygen species such as hydrogen peroxide (H2O2), is a challenge faced by all aerobic organisms. In plants, exposure to various abiotic and biotic stresses resul... Read More about Regulation of the Arabidopsis transcriptome by oxidative stress.