All Outputs (127)
Effects of bone marrow stromal cells on sensitivity of leukaemic cells to chemotherapy (2013)
Journal Article
Cytosine arabinoside (ara-C) is a key chemotherapy drug used to treat acute myeloid leukaemia (AML), however, ap- proximately 30% of patients do not respond to this therapy.
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An evaluative assay to determine resistance/sensitivity to ara- C prior... Read More about Effects of bone marrow stromal cells on sensitivity of leukaemic cells to chemotherapy.
Chemotherapy-induced cytotoxicity and genotoxicity to the bone marrow microenvironment (2013)
Journal Article
The bone marrow (BM) microenvironment is largely com- prised of mesenchymal stromal cells (MSCs) and is vital in supporting haematopoiesis. Limited studies have indicated that the BM microenvironment is damaged by chemotherapy; however the extent and... Read More about Chemotherapy-induced cytotoxicity and genotoxicity to the bone marrow microenvironment.
Point of care monitoring of hemodialysis patients with a breath ammonia measurement device based on printed polyaniline nanoparticle sensors (2013)
Journal Article
A device for measuring human breath ammonia was developed based on a single use, disposable, inkjet printed ammonia sensor fabricated using polyaniline nanoparticles. The device was optimized for sampling ammonia in human breath samples by addressing... Read More about Point of care monitoring of hemodialysis patients with a breath ammonia measurement device based on printed polyaniline nanoparticle sensors.
A case study in serendipity: Environmental researchers use of traditional and social media for dissemination (2013)
Journal Article
In the face of demands for researchers to engage more actively with a wider range of publics and to capture different kinds of research impacts and engagements, we explored the ways a small number of environmental researchers use traditional and soci... Read More about A case study in serendipity: Environmental researchers use of traditional and social media for dissemination.
RIM1α SUMOylation is required for fast synaptic vesicle exocytosis (2013)
Journal Article
The rapid, activity-dependent quantal presynaptic release of neurotransmitter is vital for brain function. The complex process of vesicle priming, fusion, and retrieval is very precisely controlled and requires thespatiotemporal coordination of multi... Read More about RIM1α SUMOylation is required for fast synaptic vesicle exocytosis.
Values associated with public involvement in health and social care research: A narrative review (2013)
Journal Article
© 2015 John Wiley & Sons Ltd. Background: Much has been written about public involvement (PI) in health and social care research, but underpinning values are rarely made explicit despite the potential for these to have significant influence on the... Read More about Values associated with public involvement in health and social care research: A narrative review.
Voltammetric behaviour of hydrogen peroxide at a silver electrode fabricated from a rewritable digital versatile disc (DVD) and its determination in water samples (2013)
Journal Article
In this study we investigated the possibility of applying Ag electrodes manufactured from recordable rewritable digital versatile discs (DVD-RW) for the voltammetric determination of hydrogen peroxide. The calibration plot was linear from 0.087 mM to... Read More about Voltammetric behaviour of hydrogen peroxide at a silver electrode fabricated from a rewritable digital versatile disc (DVD) and its determination in water samples.
Towards understanding a distinct hydrogen peroxide electrocatalytic enhancement using surfactant-based coatings on silver (2013)
Presentation / Conference Contribution
Does increase in DNA repair allow "Tolerance-to-Insult" in chemical carcinogenesis? Skin tumor experiments with MGMT-overexpressing mice (2013)
Journal Article
Several genotoxicity endpoints have been evaluated to define nonlinear dose-responses for S N 1 and S N 2 alkylating genotoxicants. Dose-response studies acknowledging the process of multistage tumorigenesis are important; however, data pertaining no... Read More about Does increase in DNA repair allow "Tolerance-to-Insult" in chemical carcinogenesis? Skin tumor experiments with MGMT-overexpressing mice.
The rulB gene of plasmid pWW0 is a hotspot for the site-specific insertion of integron-like elements found in the chromosomes of environmental Pseudomonas fluorescens group bacteria (2013)
Journal Article
Summary: The rulAB operon of Pseudomonas spp. confers fitness traits on the host and has been suggested to be a hotspot for insertion of mobile elements that carry avirulence genes. Here, for the first time, we show that rulB on plasmid pWW0 is a hot... Read More about The rulB gene of plasmid pWW0 is a hotspot for the site-specific insertion of integron-like elements found in the chromosomes of environmental Pseudomonas fluorescens group bacteria.
New developments in printed sensors for clinical and diagnostic applications (2013)
Presentation / Conference Contribution
SIMS: A smart integrated miniaturised sensor (2013)
Presentation / Conference Contribution
Online courses and social responsibility toward learners (2013)
Presentation / Conference Contribution
When we develop and validate traditional degree programmes great emphasis is placed on ensuring that applicants meet entry criteria for enrolment, and that students gain a quality experience to reach their academic and employment potential. If a stud... Read More about Online courses and social responsibility toward learners.
What are the costs and benefits of patient notification exercises following poor infection control practices in dentistry? (2013)
Journal Article
Background: Allegations of serious failures in infection control practice were made against a dentist practicing in the South West of England. The dentist (who tested negative for Blood Borne Viruses (BBVs)) was immediately suspended. Methods: Becaus... Read More about What are the costs and benefits of patient notification exercises following poor infection control practices in dentistry?.
Validation study to compare effects of processing protocols on measured Nε-(carboxymethyl)lysine and Nε-(carboxyethyl) lysine in blood (2013)
Journal Article
Epidemiological studies show that elevated plasma levels of advanced glycation end products (AGEs) are associated with diabetes, kidney disease, and heart disease. Thus AGEs have been used as disease progression markers. However, the effects of varia... Read More about Validation study to compare effects of processing protocols on measured Nε-(carboxymethyl)lysine and Nε-(carboxyethyl) lysine in blood.
Exploring the implications of changing patterns of rubella immunity in antenatal women in a South Wales valley community (2013)
Thesis
Abstract
Background/Aims: Rubella can be devastating to a foetus if maternally acquired in early pregnancy. A single rubella vaccine (SRV), given to prepubertal girls was replaced by the MMR immunisation in infancy for both sexes in 1988. Women born... Read More about Exploring the implications of changing patterns of rubella immunity in antenatal women in a South Wales valley community.
In planta induced changes in the native plasmid profile of Pseudomonas syringae pathover phaseolicola strain 1302A (2013)
Journal Article
Pseudomonas syringae pv. phaseolicola (Pph) strain 1302A, a causative agent of halo blight in the common bean Phaseolus vulgaris, contains four native plasmids designated pAV505 (150. kb), pAV506 (50. kb), pAV507 (47. kb) and pAV508 (42. kb). Pph 130... Read More about In planta induced changes in the native plasmid profile of Pseudomonas syringae pathover phaseolicola strain 1302A.