All Outputs (129)

Lessons learnt from the implementation of the Covid-19 vaccination programme in the Southwest of England (2024)
Journal Article

Background Vaccination remains one of the most successful public health interventions in preventing severe disease and death. The roll-out of Covid-19 vaccination programmes has helped protect billions of people around the world against Covid-19. Mo... Read More about Lessons learnt from the implementation of the Covid-19 vaccination programme in the Southwest of England.

Differentiation of SH-SY5Y neuroblastoma cells using retinoic acid and BDNF: A model for neuronal and synaptic differentiation in neurodegeneration (2024)
Journal Article

There has been much interest in the use of cell culture models of neurones, to avoid the animal welfare and cost issues of using primary and human-induced pluripotent stem cell (hiPSC)-derived neurones respectively. The human neuroblastoma cell line,... Read More about Differentiation of SH-SY5Y neuroblastoma cells using retinoic acid and BDNF: A model for neuronal and synaptic differentiation in neurodegeneration.

Development of a disposable, amperometric glycerol biosensor based on a screen-printed carbon electrode, modified with the electrocatalyst meldolas blue, coated with glycerol dehydrogenase and NAD+: Application to the analysis of wine quality (2024)
Journal Article

This paper describes the design and development of a novel electrochemical biosensor for measuring glycerol in wine. Our initial detailed studies were aimed at deducing the optimum conditions for biosensor operation by conducting hydrodynamic voltamm... Read More about Development of a disposable, amperometric glycerol biosensor based on a screen-printed carbon electrode, modified with the electrocatalyst meldolas blue, coated with glycerol dehydrogenase and NAD+: Application to the analysis of wine quality.

Factors influencing microplastic abundances in the sediments of a seagrass-dominated tropical atoll (2024)
Journal Article

Seagrass meadows are one of the world's most diverse ecosystems offering habitats for an extensive array of species, as well as serving as protectors of coral reefs and vital carbon sinks. Furthermore, they modify hydrodynamics by diminishing water f... Read More about Factors influencing microplastic abundances in the sediments of a seagrass-dominated tropical atoll.

Impacts of COVID-19 on UK environmental science engagement projects (2024)
Journal Article

In February-March 2020, ‘Investing in the Future of Science’ collected data on environmental science engagement with UK school-aged children. The UK then entered its first COVID-19 national lockdown. Larger or wider-reaching projects appeared more li... Read More about Impacts of COVID-19 on UK environmental science engagement projects.

Complete absence of GLUT1 does not impair human terminal erythroid differentiation (2024)
Journal Article

The Glucose transporter 1 (GLUT1) is one of the most abundant proteins within the erythrocyte membrane and is required for glucose and dehydroascorbic acid (Vitamin C precursor) transport. It is widely recognized as a key protein for red cell structu... Read More about Complete absence of GLUT1 does not impair human terminal erythroid differentiation.

SGIP1 binding to the α-helical H9 domain of cannabinoid receptor 1 promotes axonal surface expression (2024)
Journal Article

Endocannabinoid signalling mediated by cannabinoid receptor 1 (CB1R, also known as CNR1) is critical for homeostatic neuromodulation of both excitatory and inhibitory synapses. This requires highly polarised axonal surface expression of CB1R, but how... Read More about SGIP1 binding to the α-helical H9 domain of cannabinoid receptor 1 promotes axonal surface expression.

Attenuated-total-reflection Fourier-transformed spectroscopy as a rapid tool to reveal the molecular structure of insect powders as ingredients for animal feeds (2024)
Journal Article

Unsustainable agriculture contributes to disastrous global effects – insect-based feed shows potential due to their sustainable, nutritional, and waste upcycling properties. Current EU legislation restricts insect-based meals to fish, pork, and poult... Read More about Attenuated-total-reflection Fourier-transformed spectroscopy as a rapid tool to reveal the molecular structure of insect powders as ingredients for animal feeds.

IL-6 knockdown in a model of the human bone marrow, abrogates DNA damage induction in bystander cells post-chemotherapy induced cytokine release syndrome (2024)
Journal Article

Following infection or exposure to therapeutic agents, an aggressive immune response may result, termed cytokine storm (CS) or cytokine release syndrome. Here the innate immune system becomes uncontrolled, leading to serious consequences including po... Read More about IL-6 knockdown in a model of the human bone marrow, abrogates DNA damage induction in bystander cells post-chemotherapy induced cytokine release syndrome.

Effectiveness of infection prevention and control interventions in health care facilities in Africa: A systematic review (2024)
Journal Article

Background Healthcare associated infections (HAIs) are a major threat to patient safety and quality care. However, they are avoidable by implementing evidence-based infection prevention and control measures. This re... Read More about Effectiveness of infection prevention and control interventions in health care facilities in Africa: A systematic review.

Coupling of cold atmospheric plasma treatment with ultrasound-assisted extraction for enhanced recovery of bioactive compounds from cornelian cherry pomace (2024)
Journal Article

Cornelian cherry pomace is produced during the production of juice from this traditional superfood. Due to its high nutritive value, the by-product can be utilized as a source of bioactive compounds. The present study aimed to develop a sustainable m... Read More about Coupling of cold atmospheric plasma treatment with ultrasound-assisted extraction for enhanced recovery of bioactive compounds from cornelian cherry pomace.

Comparison of MXene and SWCNTs effectiveness for osteoblast differentiation: A preliminary study with MG-63 cells (2024)
Journal Article

The exceptional chemical and physical properties of nanomaterials have attracted growing interest in the field of bone tissue engineering. Single walled carbon nanotubes (SWCNTs) and MXenes are two types of unique nanomaterials that have shown promis... Read More about Comparison of MXene and SWCNTs effectiveness for osteoblast differentiation: A preliminary study with MG-63 cells.

Anticancer effects of the Novel Pyrazolyl-Urea GeGe-3 (2024)
Journal Article

In a screen of over 200 novel pyrazole compounds, ethyl 1-(2-hydroxypentyl)-5-(3-(3-(trifluoromethyl) phenyl)ureido)-1H-pyrazole-4-carboxylate (named GeGe-3) has emerged as a potential anticancer compound. GeGe-3 displays potent anti-angiogenic prope... Read More about Anticancer effects of the Novel Pyrazolyl-Urea GeGe-3.

Resistance to bacteriophage incurs a cost to virulence in drug-resistant Acinetobacter baumannii (2024)
Journal Article

Introduction . Acinetobacter baumannii is a critical priority pathogen for novel antimicrobials (World Health Organization) because of the rise in nosocomial infections and its ability to evolve resistance to last resort antibiotics. A. baumannii is... Read More about Resistance to bacteriophage incurs a cost to virulence in drug-resistant Acinetobacter baumannii.

The effect of 3D printing speed and temperature on transferability of Staphylococcus aureus and Escherichia coli during 3D food printing (2024)
Journal Article

The current study aimed to determine if the 3D-printing speed and temperature would impact the transferability of foodborne pathogens from the stainless-steel (SS) food cartridge to the 3D-printed food ink. Staphylococcus aureus and Escherichia coli... Read More about The effect of 3D printing speed and temperature on transferability of Staphylococcus aureus and Escherichia coli during 3D food printing.

Two novel Raoultella species associated with bleeding cankers of broadleaf hosts, Raoultella scottia sp. nov. and Raoultella lignicola sp. nov. (2024)
Journal Article

Seventeen Gram-negative, facultatively anaerobic bacterial strains were isolated from bleeding cankers of various broadleaf hosts and oak rhizosphere soil in Great Britain. The strains were tentatively identified as belonging to the genus Raoultella... Read More about Two novel Raoultella species associated with bleeding cankers of broadleaf hosts, Raoultella scottia sp. nov. and Raoultella lignicola sp. nov..

A systematic review of the epidemiology and the public health implications of stroke in Sub-Saharan Africa (2024)
Journal Article

Background: With approximately 11 million strokes occurring annually worldwide, and over 6.5 million deaths annually, stroke has made its place as one of the major killers in the world. Although developing countries make up more than 4/5 of the globa... Read More about A systematic review of the epidemiology and the public health implications of stroke in Sub-Saharan Africa.

P071 Exploring experiences and preferences of people with rheumatoid arthritis for digital interventions to promote physical activity (PA) (2024)
Journal Article

Background/Aims Physical activity (PA) is effective for managing symptoms of rheumatoid arthritis (RA) but people with RA are less active than their healthy counterparts. A digital intervention (DI) to promote PA, is a potential solution. There is a... Read More about P071 Exploring experiences and preferences of people with rheumatoid arthritis for digital interventions to promote physical activity (PA).

Politicisation of science in COVID-19 editorial cartoons: A comparative study of cartoons in Australia, South Africa and the United Kingdom (2024)
Journal Article

This study explores the representation of scientists and politicians in editorial cartoons from three countries: Australia, South Africa and the United Kingdom. Of 466 cartoons collected from six Sunday newspapers (two from each country) over an 1... Read More about Politicisation of science in COVID-19 editorial cartoons: A comparative study of cartoons in Australia, South Africa and the United Kingdom.

Public involvement and public engagement: An example of convergent evolution? Findings from a conceptual qualitative review of patient and public involvement, and public engagement, in health and scientific research. (2024)
Journal Article

Patient and public involvement (PPI) in health research is now well-established, whilst science, technology, engineering and mathematics (STEM) research has shifted from a focus on science communication alone to public engagement (PE) within its rese... Read More about Public involvement and public engagement: An example of convergent evolution? Findings from a conceptual qualitative review of patient and public involvement, and public engagement, in health and scientific research..