All Outputs (12)

Impaired mineral ion metabolism in a mouse model of targeted Calcium-Sensing Receptor (CaSR) deletion from vascular smooth muscle cells (2022)
Journal Article

Background
Impaired mineral ion metabolism is a hallmark of CKD–metabolic bone disorder. It can lead to pathologic vascular calcification and is associated with an increased risk of cardiovascular mortality. Loss of calcium-sensing receptor (CaSR) e... Read More about Impaired mineral ion metabolism in a mouse model of targeted Calcium-Sensing Receptor (CaSR) deletion from vascular smooth muscle cells.

Clusterin secretion is attenuated by the proinflammatory cytokines interleukin-1β and tumor necrosis factor-α in models of cartilage degradation (2020)
Journal Article

The protein clusterin has been implicated in the molecular alterations that occur in articular cartilage during osteoarthritis (OA). Clusterin exists in two isoforms with opposing functions, and their roles in cartilage have not been explored. The se... Read More about Clusterin secretion is attenuated by the proinflammatory cytokines interleukin-1β and tumor necrosis factor-α in models of cartilage degradation.

Bioreactor‐manufactured cartilage grafts repair acute and chronic osteochondral defects in large animal studies (2019)
Journal Article

Objectives: Bioreactor-based production systems have the potential to overcome limitations associated with conventional tissue engineering manufacturing methods, facilitating regulatory compliant and cost-effective production of engineered grafts for... Read More about Bioreactor‐manufactured cartilage grafts repair acute and chronic osteochondral defects in large animal studies.

Chondrogenic differentiation of human chondrocytes cultured in the absence of ascorbic acid (2018)
Journal Article

Bioreactor systems will likely play a key role in establishing regulatory compliant and cost-effective production systems for manufacturing engineered tissue grafts for clinical applications. However, the automation of bioreactor systems could become... Read More about Chondrogenic differentiation of human chondrocytes cultured in the absence of ascorbic acid.

Aggrecanase degradation of type III collagen is associated with clinical knee pain (2018)
Journal Article

There is a lack of biochemical markers for non-invasive and objective assessment of symptomatic osteoarthritis (OA). Aggrecanase activity has been shown to be associated with joint deterioration and symptomatic disease through the degradation of extr... Read More about Aggrecanase degradation of type III collagen is associated with clinical knee pain.

Chondrocyte secretome: A source of novel insights and exploratory biomarkers of osteoarthritis (2017)
Journal Article

The extracellular matrix (ECM) of articular cartilage is comprised of complex networks of proteins and glycoproteins, all of which are expressed by its resident cell, the chondrocyte. Cartilage is a unique tissue given its complexity and ability to r... Read More about Chondrocyte secretome: A source of novel insights and exploratory biomarkers of osteoarthritis.

Factors that influence cartilage implant integration during joint repair. (2016)
Journal Article

The low spontaneous healing capacity of articular cartilage, the avascular nature, and the acellularity of the interface of damaged cartilage, all these factors limit the integration between the implanted engineered cartilage and native articular car... Read More about Factors that influence cartilage implant integration during joint repair..

Expression of lumican in the synovial fluid of patients with osteoarthritis (OA) (2011)
Journal Article

Introduction Fragmentation of small leucine rich proteogly-
cans (SLRPs), including decorin, biglycan, lumican, keratocan
and fibromodulin, has been shown to occur in osteoarthritic
articular cartilage (Melrose et al. 2008). We have previously
sh... Read More about Expression of lumican in the synovial fluid of patients with osteoarthritis (OA).

Regulation of smooth muscle cell proliferation by β-catenin/T-cell factor signaling involves modulation of cyclin D1 and p21 expression (2006)
Journal Article

We previously observed that stimulation of vascular smooth muscle cell (VSMC) proliferation with growth factors is associated with dismantling of cadherin junctions and nuclear translocation of β-catenin. In this study we demonstrate directly that gr... Read More about Regulation of smooth muscle cell proliferation by β-catenin/T-cell factor signaling involves modulation of cyclin D1 and p21 expression.

N-cadherin and b-catenin signalling regulates vascular smooth muscle cell proliferation and cell cycle genes (2006)
Journal Article

Vascular smooth muscle cell (VSMC) proliferation is a key event in the pathogenesis of vascular diseases. Dismantling of cadherin junctions and translocation of b-catenin to the cytoplasm occurs in proliferating VSMCs. To determine whether N-cadherin... Read More about N-cadherin and b-catenin signalling regulates vascular smooth muscle cell proliferation and cell cycle genes.

Cruciate ligament laxity and femoral intercondylar notch narrowing in early-stage knee osteoarthritis (2005)
Journal Article

Objective. The influence of the cruciate ligaments in spontaneous osteoarthritis (OA) is not understood, although ligament rupture is known to cause secondary OA. Additionally, femoral notch narrowing at the anterior cruciate ligament (ACL) insertion... Read More about Cruciate ligament laxity and femoral intercondylar notch narrowing in early-stage knee osteoarthritis.

Fundamental subchondral bone changes in spontaneous knee osteoarthritis (2004)
Journal Article

Osteoarthritis has an unknown aetiology, and tissue samples from early stage human osteoarthritis tissue cannot be reliably obtained. Therefore understanding the development of OA relies on using animal models: such as the spontaneous changes seen in... Read More about Fundamental subchondral bone changes in spontaneous knee osteoarthritis.