Skip to main content

Research Repository

Advanced Search

Chondrocyte secretome: A source of novel insights and exploratory biomarkers of osteoarthritis

Sanchez, C.; Bay-Jensen, A. C.; Pap, T.; Dvir-Ginzberg, M.; Quasnichka, H.; Barrett-Jolley, R.; Mobasheri, A.; Henrotin, Y.

Authors

C. Sanchez

A. C. Bay-Jensen

T. Pap

M. Dvir-Ginzberg

H. Quasnichka

R. Barrett-Jolley

A. Mobasheri

Y. Henrotin



Abstract

The extracellular matrix (ECM) of articular cartilage is comprised of complex networks of proteins and glycoproteins, all of which are expressed by its resident cell, the chondrocyte. Cartilage is a unique tissue given its complexity and ability to resist repeated load and deformation. The mechanisms by which articular cartilage maintains its integrity throughout our lifetime is not fully understood, however there are numerous regulatory pathways known to govern ECM turnover in response to mechanical stimuli. To further our understanding of this field, we envision that proteomic analysis of the secretome will provide information on how the chondrocyte remodels the surrounding ECM in response to load, in addition to providing information on the metabolic state of the cell. In this review, we attempt to summarize the recent mass spectrometry-based proteomic discoveries in healthy and diseased cartilage and chondrocytes, to facilitate the discovery of novel biomarkers linked to degenerative pathologies, such as osteoarthritis (OA).

Journal Article Type Review
Acceptance Date Feb 14, 2017
Online Publication Date Feb 20, 2017
Publication Date Aug 1, 2017
Deposit Date Mar 23, 2023
Journal Osteoarthritis and Cartilage
Print ISSN 1063-4584
Electronic ISSN 1522-9653
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 25
Issue 8
Pages 1199-1209
DOI https://doi.org/10.1016/j.joca.2017.02.797
Keywords Orthopedics and Sports Medicine; Biomedical Engineering; Rheumatology; Cartilage; Chondrocyte; Osteoarthritis; Biomarker; Proteomics; Secretome
Public URL https://uwe-repository.worktribe.com/output/10339048
Publisher URL https://www.sciencedirect.com/science/article/pii/S1063458417308646?via%3Dihub