The electrochemical behavior of nitrazepam at a screen-printed carbon electrode and its determination in beverages by adsorptive stripping voltammetry

McGuire, Natasha D.; Honeychurch, Kevin C.; Hart, John P.

Abstract

The cyclic voltammetric behavior of nitrazepam was investigated at screen-printed carbon electrodes over the range1.5 V to {thorn}1.5 V. Two reduction peaks were observable on the negative scan, at 0.7 V, and 1.2 V using pH 6 buffer. On the return scan a single oxidation peak was obtained at 0.05 V. For quantitative analysis of beverages, we developed an anodic adsorptive stripping voltammetric method which required only dilution with buffer. The identification of nitrazepam and flunitrazepam could be achieved using cyclic voltammetry.© 2009 Wiley-VCH Verlag GmbH& Co. KGaA, Weinheim.

• Journal Article Type: Article
• Publication Date: Oct 1, 2009
• Deposit Date: Apr 16, 2012
• Journal: Electroanalysis
• Print ISSN: 1040-0397
• Electronic ISSN: 1521-4109
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 21
• Issue: 19
• Pages: 2165-2170
• DOI: https://doi.org/10.1002/elan.200904667
• Keywords: adsorptive stripping, voltammetry, benzodiazepine, beverages, cyclic voltammetry, screen-printed electrodes, medicinal chemistry
• Public URL: https://uwe-repository.worktribe.com/output/993369
• Publisher URL: http://dx.doi.org/10.1002/elan.200904667
• Related Public URLs: http://onlinelibrary.wiley.com/doi/10.1002/elan.200904667/abstract
• Contract Date: Nov 15, 2016