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Feasibility and construct validation of the Patient Reported Outcomes Measurement Information System (PROMIS) in systemic vasculitis

Tomasson, Gunnar; Farrar, John T.; Cuthbertson, David; McAlear, Carol A.; Ashdown, Susan; Cronholm, Peter F.; Dawson, Jill; Gebhart, Don; Lanier, Georgia; Luqmani, Raashid A.; Milman, Nataliya; Peck, Jacqueline; Robson, Joanna C.; Shea, Judy A.; Carette, Simon; Khalidi, Nader; Koening, Curry L.; Langford, Carol A.; Monach, Paul A.; Moreland, Larry; Pagnoux, Christian; Specks, Ulrich; Sreih, Antoine G.; Ytterberg, Steven R.; Merkel, Peter A.


Gunnar Tomasson

John T. Farrar

David Cuthbertson

Carol A. McAlear

Susan Ashdown

Peter F. Cronholm

Jill Dawson

Don Gebhart

Georgia Lanier

Raashid A. Luqmani

Nataliya Milman

Jacqueline Peck

Jo Robson
Consultant Associate Professor in Rheumatology

Judy A. Shea

Simon Carette

Nader Khalidi

Curry L. Koening

Carol A. Langford

Paul A. Monach

Larry Moreland

Christian Pagnoux

Ulrich Specks

Antoine G. Sreih

Steven R. Ytterberg

Peter A. Merkel


OBJECTIVE: The Patient Reported Outcome Measurement Information System (PROMIS) is a collection of item banks of self-reported health. This study assessed the feasibility and construct validity of using PROMIS instruments in vasculitis. METHODS: Data from a multicenter longitudinal cohort of subjects with systemic vasculitis were used. Instruments from 10 PROMIS item banks were selected with direct involvement of patients. Subjects completed PROMIS instruments using computer adaptive testing (CAT). The Medical Outcomes Study Short Form-36 (SF-36) was also administered. Cross-sectional construct validity was assessed by calculating correlations of PROMIS scores with SF-36 measures and physician and patient global scores for disease activity. Longitudinal construct validity was assessed by correlations of between-visit differences in PROMIS scores with differences in other measures. RESULTS: During the study period, 973 subjects came for 2306 study visits and the PROMIS collection was completed at 2276 (99%) of visits. The median time needed to complete each PROMIS instrument ranged from 40 to 55 s. PROMIS instruments correlated cross-sectionally with individual scales of the SF-36, most strongly with subscales of the SF-36 addressing the same domain as the PROMIS instrument. For example, PROMIS fatigue correlated with both the physical component score (PCS; r = -0.65) and with the mental component score (MCS; r = -0.54). PROMIS physical function correlated strongly with PCS (r = 0.81) but weakly with MCS (r = 0.29). Weaker correlations were observed longitudinally between change in PROMIS scores with change in PCS and MCS. CONCLUSION: Collection of data using CAT PROMIS instruments is feasible among patients with vasculitis and has some cross-sectional and longitudinal construct validity.


Tomasson, G., Farrar, J. T., Cuthbertson, D., McAlear, C. A., Ashdown, S., Cronholm, P. F., …Merkel, P. A. (2019). Feasibility and construct validation of the Patient Reported Outcomes Measurement Information System (PROMIS) in systemic vasculitis. Journal of Rheumatology, 46(8), 928-934.

Journal Article Type Article
Acceptance Date Feb 1, 2019
Online Publication Date Mar 1, 2019
Publication Date Aug 1, 2019
Deposit Date Apr 16, 2019
Publicly Available Date Mar 2, 2020
Journal Journal of Rheumatology
Print ISSN 1499-2752
Publisher Journal of Rheumatology
Peer Reviewed Peer Reviewed
Volume 46
Issue 8
Pages 928-934
Keywords PROMIS, vasculitis, Patient Reported Outcomes Measurements
Public URL
Publisher URL
Additional Information Additional Information : This is the author's accepted manuscript. The final published version is available here:


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