Michail Tsompanas Antisthenis.Tsompanas@uwe.ac.uk
Lecturer in Computer Science
Novelty search employed into the development of cancer treatment simulations
Tsompanas, Michail-Antisthenis; Bull, Larry; Adamatzky, Andrew; Balaz, Igor
Authors
Lawrence Bull Larry.Bull@uwe.ac.uk
School Director (Research & Enterprise) and Professor
Andrew Adamatzky Andrew.Adamatzky@uwe.ac.uk
Professor
Igor Balaz
Abstract
Conventional optimization methodologies may be hindered when the automated search is stuck into local optima because of a deceptive objective function landscape. Consequently, open ended search methodologies, such as novelty search, have been proposed to tackle this issue. Overlooking the objective, while putting pressure into discovering novel solutions may lead to better solutions in practical problems. Novelty search was employed here to optimize the simulated design of a targeted drug delivery system for tumor treatment under the PhysiCell simulator. A hybrid objective equation was used containing both the actual objective of an effective tumor treatment and the novelty measure of the possible solutions. Different weights of the two components of the hybrid equation were investigated to unveil the significance of each one.
Citation
Tsompanas, M., Bull, L., Adamatzky, A., & Balaz, I. (2020). Novelty search employed into the development of cancer treatment simulations. Informatics in Medicine Unlocked, 19, 100347. https://doi.org/10.1016/j.imu.2020.100347
Journal Article Type | Article |
---|---|
Acceptance Date | May 4, 2020 |
Online Publication Date | May 20, 2020 |
Publication Date | 2020 |
Deposit Date | May 22, 2021 |
Publicly Available Date | May 26, 2021 |
Journal | Informatics in Medicine Unlocked |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 19 |
Pages | 100347 |
DOI | https://doi.org/10.1016/j.imu.2020.100347 |
Public URL | https://uwe-repository.worktribe.com/output/7123600 |
Publisher URL | https://doi.org/10.1016/j.imu.2020.100347 |
Additional Information | This article is maintained by: Elsevier; Article Title: Novelty search employed into the development of cancer treatment simulations; Journal Title: Informatics in Medicine Unlocked; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.imu.2020.100347; Content Type: article; Copyright: © 2020 The Authors. Published by Elsevier Ltd. |
Files
Novelty search employed into the development of cancer treatment simulations
(1.5 Mb)
PDF
Licence
http://creativecommons.org/licenses/by-nc-nd/4.0/
Publisher Licence URL
http://creativecommons.org/licenses/by-nc-nd/4.0/
You might also like
A generalised dropout mechanism for distributed systems
(2022)
Journal Article
Evolving Boolean regulatory networks with variable gene expression times
(2021)
Book Chapter
On coevolution: Asymmetry in the NKCS model
(2021)
Journal Article
Downloadable Citations
About UWE Bristol Research Repository
Administrator e-mail: repository@uwe.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search