Outputs (16)

MIBiG 4.0: Advancing biosynthetic gene cluster curation through global collaboration (2024)
Journal Article

Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is governed by s... Read More about MIBiG 4.0: Advancing biosynthetic gene cluster curation through global collaboration.

Unlocking fungal secrets: The biosynthesis and potential of the maleidrides (2024)
Presentation / Conference Contribution

Fungi are renowned as producers of high-value natural products, exemplified by the antibiotic cephalosporins, the HMG-CoA reductase inhibitor (cholesterol-lowering) statins and the antifungal strobilurin derivatives. Together, these compounds have a... Read More about Unlocking fungal secrets: The biosynthesis and potential of the maleidrides.

Maleidride biosynthesis - construction of dimeric anhydrides - more than just heads or tails (2022)
Journal Article

Covering: up to early 2022 Maleidrides are a family of polyketide-based dimeric natural products isolated from fungi. Many maleidrides possess significant bioactivities, making them attractive pharmaceutical or agrochemical lead compounds. Their unus... Read More about Maleidride biosynthesis - construction of dimeric anhydrides - more than just heads or tails.

Cloning and expression of Burkholderia polyyne biosynthetic gene clusters in Paraburkholderia hosts provides a strategy for biopesticide development (2022)
Journal Article

Burkholderia have potential as biocontrol agents because they encode diverse biosynthetic gene clusters (BGCs) for a range of antimicrobial metabolites. Given the opportunistic pathogenicity associated with Burkholderia species, heterologous BGC expr... Read More about Cloning and expression of Burkholderia polyyne biosynthetic gene clusters in Paraburkholderia hosts provides a strategy for biopesticide development.

In silico analyses of maleidride biosynthetic gene clusters (2022)
Journal Article

Maleidrides are a family of structurally related fungal natural products, many of which possess diverse, potent bioactivities. Previous identification of several maleidride biosynthetic gene clusters, and subsequent experimental work, has determined... Read More about In silico analyses of maleidride biosynthetic gene clusters.

Core steps to the Azaphilone family of fungal natural products (2021)
Journal Article

Azaphilones are a family of polyketide-based fungal natural products that exhibit interesting and useful bioactivities. This minireview explores the literature on various characterised azaphilone biosynthetic pathways, which allows for a proposed con... Read More about Core steps to the Azaphilone family of fungal natural products.

Cleaning the cellular factory: Deletion of McrA in Aspergillus oryzae NSAR1 and the generation of a novel kojic acid deficient strain for cleaner heterologous production of secondary metabolites (2021)
Journal Article

The use of filamentous fungi as cellular factories, where natural product pathways can be refactored and expressed in a host strain, continues to aid the field of natural product discovery. Much work has been done to develop host strains which are ge... Read More about Cleaning the cellular factory: Deletion of McrA in Aspergillus oryzae NSAR1 and the generation of a novel kojic acid deficient strain for cleaner heterologous production of secondary metabolites.

The biogenetic origin of the biologically active Naematolin of Hypholoma species involves an unusual sesquiterpene synthase (2019)
Journal Article

Naematolin is a biologically active sesquiterpene produced by Hypholoma species. Low titres and complex structure constrain the exploitation of this secondary metabolite. Here, we de novo sequenced the H. fasciculare genome to identify a candidate bi... Read More about The biogenetic origin of the biologically active Naematolin of Hypholoma species involves an unusual sesquiterpene synthase.

Molecular basis of methylation and chain-length programming in a fungal iterative highly reducing polyketide synthase (2019)
Journal Article

Exchange of 32 different sub-fragments of the C-methyltransferase (C-MeT), pseudo-ketoreductase (ΨKR) and ketoreductase (KR) catalytic domains of the tenellin iterative Type I polyketide synthase non ribosomal peptide synthetase (PKS-NRPS) TENS by ho... Read More about Molecular basis of methylation and chain-length programming in a fungal iterative highly reducing polyketide synthase.

Genome sequence of Lecanicillium fungicola 150-1, the causal agent of dry bubble disease (2019)
Journal Article

The fungus Lecanicillium fungicola causes dry bubble disease in the white button mushroom Agaricus bisporus. Control strategies are limited, as both the host and pathogen are fungi, and there is limited understanding of the interactions in this patho... Read More about Genome sequence of Lecanicillium fungicola 150-1, the causal agent of dry bubble disease.