In silico analyses of maleidride biosynthetic gene clusters

Williams, Katherine; de Mattos-Shipley, Kate M.J.; Willis, Christine L.; Bailey, Andrew M.

Abstract

Maleidrides are a family of structurally related fungal natural products, many of which possess diverse, potent bioactivities. Previous identification of several maleidride biosynthetic gene clusters, and subsequent experimental work, has determined the ‘core’ set of genes required to construct the characteristic medium-sized alicyclic ring with maleic anhydride moieties. Through genome mining, this work has used these core genes to discover ten entirely novel putative maleidride biosynthetic gene clusters, amongst both publicly available genomes, and encoded within the genome of the previously un-sequenced epiheveadride producer Wicklowia aquatica CBS 125634. We have undertaken phylogenetic analyses and comparative bioinformatics on all known and putative maleidride biosynthetic gene clusters to gain further insights regarding these unique biosynthetic pathways.

• Journal Article Type: Article
• Acceptance Date: Jan 23, 2022
• Online Publication Date: Feb 17, 2022
• Publication Date: Feb 17, 2022
• Deposit Date: Apr 10, 2024
• Publicly Available Date: Apr 10, 2024
• Journal: Fungal Biology and Biotechnology
• Electronic ISSN: 2054-3085
• Publisher: BioMed Central
• Peer Reviewed: Peer Reviewed
• Volume: 9
• Issue: 1
• Article Number: 2
• DOI: https://doi.org/10.1186/s40694-022-00132-z
• Public URL: https://uwe-repository.worktribe.com/output/11848466
• Publisher URL: https://doi.org/10.1186/s40694-022-00132-z