Skip to main content

Research Repository

Advanced Search

Core steps to the Azaphilone family of fungal natural products

Williams, Katherine; Greco, Claudio; Bailey, Andrew M; Willis, Christine L

Core steps to the Azaphilone family of fungal natural products Thumbnail


Authors

Katherine Williams

Claudio Greco

Andrew M Bailey

Christine L Willis



Abstract

Azaphilones are a family of polyketide-based fungal natural products that exhibit interesting and useful bioactivities. This minireview explores the literature on various characterised azaphilone biosynthetic pathways, which allows for a proposed consensus scheme for the production of the core azaphilone structure, as well as identifying early diversification steps during azaphilone biosynthesis. A consensus understanding of the core enzymatic steps towards a particular family of fungal natural products can aid in genome-mining experiments. Genome mining for novel fungal natural products is a powerful technique for both exploring chemical space and providing new insights into fungal natural product pathways.

Journal Article Type Review
Acceptance Date Jun 28, 2021
Online Publication Date Jun 30, 2021
Publication Date Nov 3, 2021
Deposit Date Apr 10, 2024
Publicly Available Date Apr 10, 2024
Journal ChemBioChem
Print ISSN 1439-4227
Electronic ISSN 1439-7633
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 22
Issue 21
Pages 3027-3036
DOI https://doi.org/10.1002/cbic.202100240
Public URL https://uwe-repository.worktribe.com/output/11881261
Publisher URL https://doi.org/10.1002%2Fcbic.202100240; http://dx.doi.org/10.1002/cbic.202100240

Files





You might also like



Downloadable Citations