Katherine Williams
Core steps to the Azaphilone family of fungal natural products
Williams, Katherine; Greco, Claudio; Bailey, Andrew M; Willis, Christine L
Authors
Claudio Greco
Andrew M Bailey
Christine L Willis
Abstract
Azaphilones are a family of polyketide-based fungal natural products that exhibit interesting and useful bioactivities. This minireview explores the literature on various characterised azaphilone biosynthetic pathways, which allows for a proposed consensus scheme for the production of the core azaphilone structure, as well as identifying early diversification steps during azaphilone biosynthesis. A consensus understanding of the core enzymatic steps towards a particular family of fungal natural products can aid in genome-mining experiments. Genome mining for novel fungal natural products is a powerful technique for both exploring chemical space and providing new insights into fungal natural product pathways.
Journal Article Type | Review |
---|---|
Acceptance Date | Jun 28, 2021 |
Online Publication Date | Jun 30, 2021 |
Publication Date | Nov 3, 2021 |
Deposit Date | Apr 10, 2024 |
Publicly Available Date | Apr 10, 2024 |
Journal | ChemBioChem |
Print ISSN | 1439-4227 |
Electronic ISSN | 1439-7633 |
Publisher | Wiley |
Peer Reviewed | Peer Reviewed |
Volume | 22 |
Issue | 21 |
Pages | 3027-3036 |
DOI | https://doi.org/10.1002/cbic.202100240 |
Public URL | https://uwe-repository.worktribe.com/output/11881261 |
Publisher URL | https://doi.org/10.1002%2Fcbic.202100240; http://dx.doi.org/10.1002/cbic.202100240 |
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Core steps to the Azaphilone family of fungal natural products
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Licence
http://creativecommons.org/licenses/by/4.0/
Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/
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