Core steps to the Azaphilone family of fungal natural products

Williams, Katherine; Greco, Claudio; Bailey, Andrew M; Willis, Christine L

Abstract

Azaphilones are a family of polyketide-based fungal natural products that exhibit interesting and useful bioactivities. This minireview explores the literature on various characterised azaphilone biosynthetic pathways, which allows for a proposed consensus scheme for the production of the core azaphilone structure, as well as identifying early diversification steps during azaphilone biosynthesis. A consensus understanding of the core enzymatic steps towards a particular family of fungal natural products can aid in genome-mining experiments. Genome mining for novel fungal natural products is a powerful technique for both exploring chemical space and providing new insights into fungal natural product pathways.

• Journal Article Type: Review
• Acceptance Date: Jun 28, 2021
• Online Publication Date: Jun 30, 2021
• Publication Date: Nov 3, 2021
• Deposit Date: Apr 10, 2024
• Publicly Available Date: Apr 10, 2024
• Journal: ChemBioChem
• Print ISSN: 1439-4227
• Electronic ISSN: 1439-7633
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 22
• Issue: 21
• Pages: 3027-3036
• DOI: https://doi.org/10.1002/cbic.202100240
• Public URL: https://uwe-repository.worktribe.com/output/11881261
• Publisher URL: https://doi.org/10.1002%2Fcbic.202100240; http://dx.doi.org/10.1002/cbic.202100240