Outputs (84)

Assessing barriers and opportunities for the improvement of laboratory performance and robust surveillance of antimicrobial resistance in Nigeria – A quantitative study (2025)
Journal Article

Background
Good quality data is essential in optimising containment strategies for antimicrobial resistance, a global public health threat estimated to cause around 10 million deaths yearly and up-to 5% loss in GDP by 2050 if left unaddressed. The l... Read More about Assessing barriers and opportunities for the improvement of laboratory performance and robust surveillance of antimicrobial resistance in Nigeria – A quantitative study.

Validation of a sensor system for the measurement of breath ammonia using selected-ion flow-tube mass spectrometry (2024)
Journal Article

The measurement of trace breath gases is of growing interest for its potential to provide non-invasive physiological information in health and disease. While instrumental techniques such as selected-ion flow-tube mass spectrometry (SIFT-MS) can achie... Read More about Validation of a sensor system for the measurement of breath ammonia using selected-ion flow-tube mass spectrometry.

Identifying targetable metabolic dependencies across colorectal cancer progression (2024)
Journal Article

Colorectal cancer (CRC) is a multi-stage process initiated through the formation of a benign adenoma, progressing to an invasive carcinoma and finally metastatic spread. Tumour cells must adapt their metabolism to support the energetic and biosynthet... Read More about Identifying targetable metabolic dependencies across colorectal cancer progression.

Spliceosomal vulnerability of MYCN-amplified neuroblastoma is contingent on PRMT5-mediated regulation of epitranscriptomic and metabolomic pathways (2024)
Journal Article

Approximately 50% of poor prognosis neuroblastomas arise due to MYCN over-expression. We previously demonstrated that MYCN and PRMT5 proteins interact and PRMT5 knockdown led to apoptosis of MYCN amplified (MNA) neuroblastoma. Here we evaluate the hi... Read More about Spliceosomal vulnerability of MYCN-amplified neuroblastoma is contingent on PRMT5-mediated regulation of epitranscriptomic and metabolomic pathways.

Video gaming and sleep in adults: A systematic review (2024)
Journal Article

Video games (VGs) are one of the most common forms of entertainment and their diffusion is constantly increasing. Although largely studied in the framework of their relationship with mental and physical health, the relationship of VGs with sleep are... Read More about Video gaming and sleep in adults: A systematic review.

The peer review process: Past, present, and future (2024)
Journal Article

The peer review process is a fundamental aspect of modern scientific paper publishing, underpinning essential quality control. First conceptualised in the 1700s, it is an iterative process that aims to elevate scientific literature to the highest sta... Read More about The peer review process: Past, present, and future.

Effectiveness of infection prevention and control interventions in health care facilities in Africa: A systematic review (2024)
Journal Article

Background Healthcare associated infections (HAIs) are a major threat to patient safety and quality care. However, they are avoidable by implementing evidence-based infection prevention and control measures. This re... Read More about Effectiveness of infection prevention and control interventions in health care facilities in Africa: A systematic review.

An evaluation of blood transfusion service in Saudi Arabia (2024)
Thesis

Background: Blood transfusion is needed to support the care given to many medical and surgical patients, and can reduce morbidity and mortality. The blood transfusion service (BTS) in the Kingdom of Saudi Arabia (KSA) is hospital-based. This study ai... Read More about An evaluation of blood transfusion service in Saudi Arabia.

Editorial: The RNA revolution and cancer (2024)
Journal Article

RNA biology has revolutionized cancer understanding and treatment, especially in endocrine-related malignancies. This editorial highlights RNA's crucial role in cancer progression, emphasizing its influence on tumor heterogeneity and behavior. Proces... Read More about Editorial: The RNA revolution and cancer.

The effects of glucose supplementation on the development of Acinetobacter baumannii biofilms (2024)
Presentation / Conference Contribution

The Effect of Glucose on The Development of Acinetobacter baumannii Biofilm

Background: Acinetobacter baumannii, is an opportunistic pathogen causing pneumonia, bacteraemia, wound and urinary tract infections with high mortality rates due to multi... Read More about The effects of glucose supplementation on the development of Acinetobacter baumannii biofilms.

Understanding the chemotherapy-induced bystander effect; an evaluation of the role of cytokine storm in an in-vitro model of the human bone marrow (2024)
Thesis

The phenomenon of donor cell leukaemia (DCL) occurs following haematopoietic stem cell transplantation (HSCT), but its aetiology is currently unknown. Previous work within the research group identified a chemotherapy-induced bystander effect (CIBE) i... Read More about Understanding the chemotherapy-induced bystander effect; an evaluation of the role of cytokine storm in an in-vitro model of the human bone marrow.

Comparison of the effects of antibiotics and essential oils against Acinetobacter baumannii in planktonic and biofilm conditions (2023)
Presentation / Conference Contribution

Background: Acinetobacter baumannii is a common nosocomial pathogen causing pneumonia, bacteraemia, wound and urinary tract infections. Due to improper and frequent antibiotic use A. baumannii has become multi-drug resistant, the World Health Organi... Read More about Comparison of the effects of antibiotics and essential oils against Acinetobacter baumannii in planktonic and biofilm conditions.

Gut bacteria promote proliferation in benign S/RG/C2 colorectal tumour cells, and promote proliferation, migration and invasion in malignant HCT116 cells (2023)
Journal Article

Colorectal cancer (CRC) is a significant global health burden with a rising incidence worldwide. Distinct bacterial populations are associated with CRC development and progression, and it is thought that the relationship between CRC and associated gu... Read More about Gut bacteria promote proliferation in benign S/RG/C2 colorectal tumour cells, and promote proliferation, migration and invasion in malignant HCT116 cells.

Quantifying the microstructural and biomechanical changes in the porcine ventricles during growth and remodelling (2023)
Journal Article

Cardiac tissue growth and remodelling (G & R) occur in response to the changing physiological demands of the heart after birth. The early shift to pulmonary circulation produces an immediate increase in ventricular workload, causing microstructural a... Read More about Quantifying the microstructural and biomechanical changes in the porcine ventricles during growth and remodelling.

Diversity and inclusion: Creating a culture of equity in the biosciences (2023)
Presentation / Conference Contribution

Abstract: Globally, science remains exclusive and inequalities continue for minoritised communities in the UK, US and across the world. Access to learning resources, quality of learning experiences and graduate outcomes continues to impact minoritise... Read More about Diversity and inclusion: Creating a culture of equity in the biosciences.

Going circular: history, present, and future of circRNAs in cancer. (2023)
Journal Article

To date, thousands of highly abundant and conserved single-stranded RNA molecules shaped into ring structures (circRNAs) have been identified. CircRNAs are multifunctional molecules that have been shown to regulate gene expression transcriptionally a... Read More about Going circular: history, present, and future of circRNAs in cancer..

Metabolic reprogramming and the role of the BCAT protein - implications for type 2 diabetes and Alzheimer's disease (2023)
Thesis

Introduction: Oxidative stress and impaired homeostasis are key features of type 2 diabetes mellitus, which is comorbid with Alzheimer’s disease. Dysregulation of the branched-chain aminotransferase protein, which is overexpressed in AD, is suggested... Read More about Metabolic reprogramming and the role of the BCAT protein - implications for type 2 diabetes and Alzheimer's disease.

Dual wavelength retinal vessel oximetry – influence of fundus pigmentation (2022)
Journal Article

Background: Clinical methods examining oxygenation parameters in humans have been used in many different care settings, but concerns have been raised regarding their clinical utility when assessing people with darker skin pigmentation. While saturati... Read More about Dual wavelength retinal vessel oximetry – influence of fundus pigmentation.

Strengthening management, community engagement, and sustainability of the subnational response to accelerate malaria elimination in Namibia (2022)
Journal Article

Leadership and management skills are critical for health programs to deliver high-quality interventions in complex systems. In malaria-eliminating countries, national and subnational health teams are reorienting strategies to address focal transmissi... Read More about Strengthening management, community engagement, and sustainability of the subnational response to accelerate malaria elimination in Namibia.

Accessibility to protected areas increases primate hunting intensity in Bioko Island, Equatorial Guinea (2022)
Journal Article

Bioko is one of the most important sites for African primate conservation; yet it has seen a severe decline in its primate populations due to illegal hunting to supply a thriving wildmeat trade. The completion in 2015 of a new road bisecting the Gran... Read More about Accessibility to protected areas increases primate hunting intensity in Bioko Island, Equatorial Guinea.