Zodwa Dlamini
Editorial: The RNA revolution and cancer
Dlamini, Zodwa; Ladomery, Michael; Kahraman, Abdullah
Abstract
RNA biology has revolutionized cancer understanding and treatment, especially in endocrine-related malignancies. This editorial highlights RNA's crucial role in cancer progression, emphasizing its influence on tumor heterogeneity and behavior. Processes like alternative splicing and noncoding RNA regulation shape cancer biology, with microRNAs, long noncoding RNAs, and circular RNAs orchestrating gene expression dynamics. Aberrant RNA signatures hold promise as diagnostic and prognostic biomarkers in endocrine-related cancers. Recent findings, such as aberrant PI3Kδ splice isoforms and epithelial-mesenchymal transition-related lncRNA signatures, unveil potential therapeutic targets for personalized treatments. Insights into m6A-associated lncRNA prognostic models and the function of lncRNA LINC00659 in gastric cancer represents ongoing research in this field. As understanding of RNA's role in cancer expands, personalized therapies offer transformative potential in managing endocrine-related malignancies. This signifies a significant stride towards precision oncology, fostering innovation for more effective cancer care.
| Journal Article Type | Editorial |
|---|---|
| Acceptance Date | May 1, 2024 |
| Online Publication Date | May 20, 2024 |
| Publication Date | May 20, 2024 |
| Deposit Date | May 20, 2024 |
| Publicly Available Date | May 21, 2024 |
| Journal | Frontiers in Endocrinology |
| Electronic ISSN | 1664-2392 |
| Publisher | Frontiers Media |
| Peer Reviewed | Peer Reviewed |
| Volume | 15 |
| Article Number | 1422599 |
| DOI | https://doi.org/10.3389/fendo.2024.1422599 |
| Keywords | cancer, microRNAs, alternative splicing, long noncoding RNAs, endocrine-related cancers, RNA biology, circular RNAs, noncoding RNAs |
| Public URL | https://uwe-repository.worktribe.com/output/12000614 |
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The RNA revolution and cancer
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