Mark Lyttle's Outputs (20)

Seroprevalence of SARS-CoV-2 antibodies in children of United Kingdom healthcare workers: A prospective multicentre cohort study protocol (2020)
Journal Article

Background:
A novel coronavirus SARS-CoV-2 has been responsible for a worldwide pandemic. Children typically have very mild, or no, symptoms of infection. This makes estimations of seroprevalence in children difficult. Research is therefore required... Read More about Seroprevalence of SARS-CoV-2 antibodies in children of United Kingdom healthcare workers: A prospective multicentre cohort study protocol.

Kinetics and seroprevalence of SARS-CoV-2 antibodies in children (2020)
Journal Article

Validating clinical practice guidelines for the management of children with non-blanching rashes in the UK (PiC): A prospective, multicentre cohort study (2020)
Journal Article

Background:
No previous studies have validated current clinical practice guidelines for the management of non-blanching rashes in children who have received meningococcal B and C vaccinations. The aim of this study was to evaluate the performance o... Read More about Validating clinical practice guidelines for the management of children with non-blanching rashes in the UK (PiC): A prospective, multicentre cohort study.

Seroprevalence of SARS-CoV-2 antibodies in children: A prospective multicentre cohort study (2020)
Journal Article

Background: Studies based on molecular testing of oral/nasal swabs underestimate SARS-CoV-2 infection due to issues with test sensitivity, test timing and selection bias. The objective of this study was to report the presence of SARS-CoV-2 antibodies... Read More about Seroprevalence of SARS-CoV-2 antibodies in children: A prospective multicentre cohort study.

Need for recovery amongst emergency physicians in the UK and Ireland: A cross-sectional survey (2020)
Journal Article

OBJECTIVES: To determine the need for recovery (NFR) among emergency physicians and to identify demographic and occupational characteristics associated with higher NFR scores. DESIGN: Cross-sectional electronic survey. SETTING: Emergency departments... Read More about Need for recovery amongst emergency physicians in the UK and Ireland: A cross-sectional survey.

National survey of feasibility of NIV trials for management of children with bronchiolitis (2020)
Journal Article

Background Bronchiolitis is a major cause of admission to hospital in children. Non-invasive ventilation (NIV) support with continuous positive airway pressure (CPAP) or high-flow nasal cannula (HFNC) oxygen is routinely used for infants in the UK wi... Read More about National survey of feasibility of NIV trials for management of children with bronchiolitis.

Diagnostic test accuracy of point-of-care procalcitonin to diagnose serious bacterial infections in children (2020)
Journal Article

Background: The National Institute for Health and Care Excellence (NICE) have called for research into the role of biomarkers, and specifically procalcitonin (PCT), for the early diagnosis of serious bacterial infections (SBI) in children. The aim of... Read More about Diagnostic test accuracy of point-of-care procalcitonin to diagnose serious bacterial infections in children.

Planning for success: Overcoming challenges to recruitment and conduct of an open-label emergency department-led paediatric trial (2020)
Journal Article

Background Key challenges to the successful conduct of The Emergency treatment with Levetiracetam or Phenytoin in Status Epilepticus in children (EcLiPSE) trial were identified at the pre-trial stage. These included practitioner anxieties about condu... Read More about Planning for success: Overcoming challenges to recruitment and conduct of an open-label emergency department-led paediatric trial.

Fifteen minute consultation: When can I use a medical app? (2020)
Journal Article

Advances in mobile device technology and internet connectivity have created powerful new mobile health (mHealth) and telemedicine capabilities. The guidelines regarding mHealth use in the clinical environment can be conflicting, which has resulted in... Read More about Fifteen minute consultation: When can I use a medical app?.

Emergency care provided to refugee children in Europe: RefuNET: A cross-sectional survey study (2020)
Journal Article

Background Refugee children and young people have complex healthcare needs. However, issues related to acute healthcare provision for refugee children across Europe remain unexplored. This study aimed to describe the urgent and emergency healthcare n... Read More about Emergency care provided to refugee children in Europe: RefuNET: A cross-sectional survey study.

Prescribing in a paediatric emergency: A PERUKI survey of prescribing and resuscitation aids (2020)
Journal Article

Aim: The aim was to investigate the use of paper-based and electronic prescribing and resuscitation aids in paediatric emergency care from a departmental and individual physician perspective. Methods: A two-stage web-based self-report questionnaire w... Read More about Prescribing in a paediatric emergency: A PERUKI survey of prescribing and resuscitation aids.

Seven-step framework to enhance practitioner explanations and parental understandings of research without prior consent in paediatric emergency and critical care trials (2020)
Journal Article

Background: Alternatives to prospective informed consent enable the conduct of paediatric emergency and critical care trials. Research without prior consent (RWPC) involves practitioners approaching parents after an intervention has been given and se... Read More about Seven-step framework to enhance practitioner explanations and parental understandings of research without prior consent in paediatric emergency and critical care trials.

Risk of traumatic intracranial haemorrhage in children with bleeding disorders (2020)
Journal Article

Objective: To assess computerized tomography (CT) use and the risk of intracranial haemorrhage (ICH) in children with bleeding disorders following a head trauma
Design: Multicentre prospective observational study
Setting: 10 paediatric emergency de... Read More about Risk of traumatic intracranial haemorrhage in children with bleeding disorders.

COVID-19 emergency response assessment study: a prospective longitudinal survey of frontline doctors in the UK and Ireland: study protocol (2020)
Journal Article

INTRODUCTION: The COVID-19 pandemic is putting an unprecedented strain on healthcare systems globally. The psychological impact on frontline doctors of dealing with the COVID-19 pandemic is currently unknown. This longitudinal professional survey aim... Read More about COVID-19 emergency response assessment study: a prospective longitudinal survey of frontline doctors in the UK and Ireland: study protocol.

International practice patterns of antibiotic therapy and laboratory testing in bronchiolitis (2020)
Journal Article

BACKGROUND AND OBJECTIVES: International patterns of antibiotic use and laboratory testing in bronchiolitis in emergency departments are unknown. Our objective is to evaluate variation in the use of antibiotics and nonindicated tests in infants with... Read More about International practice patterns of antibiotic therapy and laboratory testing in bronchiolitis.

Loop-mediated isothermal amplification for the early diagnosis of invasive meningococcal disease in children (2020)
Journal Article

Background Rapid molecular diagnostic testing has the potential to improve the early recognition of meningococcal disease (MD). The aim of this study was to report on the diagnostic test accuracy of point-of-care loop-mediated isothermal amplificatio... Read More about Loop-mediated isothermal amplification for the early diagnosis of invasive meningococcal disease in children.

Exposure and confidence with critical non-airway procedures: A global survey of paediatric emergency medicine physicians (2020)
Journal Article

Background:
Children rarely experience critical illness, resulting in low exposure of emergency physicians (EPs) to critical procedures. Our primary objective was to describe senior EP confidence, most recent performance and/or supervision of criti... Read More about Exposure and confidence with critical non-airway procedures: A global survey of paediatric emergency medicine physicians.

The effect of patient observation on cranial computed tomography rates in children with minor head trauma (2020)
Journal Article

Background
Management of children with minor blunt head trauma often includes a period of observation to determine the need for cranial computed tomography (CT). Our objective was to estimate the effect of planned observation on CT use for each Pedi... Read More about The effect of patient observation on cranial computed tomography rates in children with minor head trauma.

Exposure and confidence across critical airway procedures in pediatric emergency medicine: An international survey study (2020)
Journal Article

Background: Airway management procedures are critical for emergency medicine (EM) physicians, but rarely performed skills in pediatric patients. Worldwide experience with respect to frequency and confidence in performing airway management skills has... Read More about Exposure and confidence across critical airway procedures in pediatric emergency medicine: An international survey study.

Acute severe paediatric asthma: Study protocol for the development of a core outcome set, a Pediatric Emergency Research Networks (PERN) study (2020)
Journal Article

Background
Acute severe childhood asthma is an infrequent, but potentially life-threatening emergency condition. There is a wide range of different approaches to this condition, with very little supporting evidence, leading to significant variation... Read More about Acute severe paediatric asthma: Study protocol for the development of a core outcome set, a Pediatric Emergency Research Networks (PERN) study.