Mark Lyttle's Outputs (157)

Predictors of persisting symptoms after concussion in children following a traumatic brain injury: A longitudinal retrospective cohort study (2025)
Journal Article

Objectives: To identify predictors of persisting symptoms after concussion (PSaC) in children, following any medically attended traumatic brain injury (TBI). Design: Retrospective cohort study. Setting: Linked primary and secondary care data from UK... Read More about Predictors of persisting symptoms after concussion in children following a traumatic brain injury: A longitudinal retrospective cohort study.

Factors influencing paramedic conveyance decisions when attending children with minor head injury: A qualitative study (2025)
Journal Article

Introduction Children with head injury are commonly transported to the ED by ambulance. However, most of those conveyed are deemed non-serious and are discharged at triage. Research is needed to explore the factors that influence paramedics when deci... Read More about Factors influencing paramedic conveyance decisions when attending children with minor head injury: A qualitative study.

Factors associated with repeat emergency department visits for mental health care in adolescents: A scoping review (2024)
Journal Article

1.1Objectives
The aim of this review was to identify factors associated with multiple visits to emergency department (ED) services for mental health care in adolescents.
1.2Methods
Electronic databases (MEDLINE, PsycINFO, Embase, CINAHL, Web of Sc... Read More about Factors associated with repeat emergency department visits for mental health care in adolescents: A scoping review.

Which elements of hospital-based clinical decision support tools for the assessment and management of children with head injury can be adapted for use by paramedics in prehospital care? A systematic mapping review and narrative synthesis (2024)
Journal Article

Objective Hospital-based clinical decision tools support clinician decision-making when a child presents to the emergency department with a head injury, particularly regarding CT scanning. However, there is no decision tool to support prehospital cli... Read More about Which elements of hospital-based clinical decision support tools for the assessment and management of children with head injury can be adapted for use by paramedics in prehospital care? A systematic mapping review and narrative synthesis.

The clinical impact of serious respiratory disease in children under the age of two years during the 2021-2022 bronchiolitis season in England, Scotland and Ireland (2023)
Journal Article

Interventions introduced to reduce the spread of SARS-CoV-2 led to a widespread reduction in childhood infections. However, from spring 2021 onwards the United Kingdom and Ireland experienced an unusual out-of-season epidemic of respiratory disease.... Read More about The clinical impact of serious respiratory disease in children under the age of two years during the 2021-2022 bronchiolitis season in England, Scotland and Ireland.

Core outcomes and factors influencing the experience of care for children with severe acute exacerbations of asthma: A qualitative study (2023)
Journal Article

Objective To identify the outcomes considered important, and factors influencing the patient experience, for parents and caregivers of children presenting to hospital with a severe acute exacerbation of asthma. This work contributes to the outcome-id... Read More about Core outcomes and factors influencing the experience of care for children with severe acute exacerbations of asthma: A qualitative study.

Applying clinical decision aids for the assessment and management of febrile infants presenting to emergency care in the UK and Ireland: Febrile Infant Diagnostic Assessment and Outcome (FIDO) Study protocol (2023)
Journal Article

Introduction Febrile infants 90 days and younger are at risk of invasive bacterial infections (bacteraemia and meningitis) and urinary tract infections. Together this is previously termed serious bacterial infection with an incidence of approximately... Read More about Applying clinical decision aids for the assessment and management of febrile infants presenting to emergency care in the UK and Ireland: Febrile Infant Diagnostic Assessment and Outcome (FIDO) Study protocol.

Comparison of injury patterns and interventions between adolescent, adult and paediatric trauma cases: A cross-sectional review of TARN data (2023)
Journal Article

Objectives The aim is to compare adolescent (10-24.99 years) trauma patterns and interventions to adult (≥25) and paediatric cases (<10) and to identify any transition points. Design and setting Data were collected from the Trauma and Audit Research...

A diagnostic accuracy study to evaluate standard rapid diagnostic test (RDT) alone to safely rule out imported malaria in children presenting to UK emergency departments (2023)
Journal Article

BACKGROUND: Microscopy is the gold standard for malaria diagnosis but is dependent on trained personnel. Rapid diagnostic tests (RDTs) form the mainstay of diagnosis in endemic areas without access to high-quality microscopy. We aimed to evaluate whe... Read More about A diagnostic accuracy study to evaluate standard rapid diagnostic test (RDT) alone to safely rule out imported malaria in children presenting to UK emergency departments.

Factors related to adverse long-term outcomes after mild traumatic brain injury in children: A scoping review (2023)
Journal Article

Objective: To identify demographic, premorbid and injury-related factors, or biomarkers associated with long-term (≥3 months) adverse outcomes in children after mild traumatic brain injury (mTBI). Design: Scoping review of literature. Patients: Child... Read More about Factors related to adverse long-term outcomes after mild traumatic brain injury in children: A scoping review.

International perspective on research priorities and outcome measures of importance in the care of children with acute exacerbations of asthma: A qualitative interview study (2023)
Journal Article

Background: Acute exacerbations of asthma are common in children, however, treatment decisions for severe exacerbations are challenging due to a lack of robust evidence. In order to create more robust research, a core set of outcome measures needs to... Read More about International perspective on research priorities and outcome measures of importance in the care of children with acute exacerbations of asthma: A qualitative interview study.

Assessment and management of children with head injury: Practice and opinion (2023)
Journal Article

Background: Head injury is common in children with approximately 700 000 attendances at emergency departments annually; one-third are conveyed by ambulance. However, 75% of them are discharged with no treatment. Most head-injured children could be ma... Read More about Assessment and management of children with head injury: Practice and opinion.

The journey back to normality: Support systems and posttrauma needs following exposure to single-incident trauma among children and adolescents (2023)
Journal Article

Social support has been linked to posttrauma adjustment in children and adolescents, but the components of good support remain poorly defined. We conducted qualitative interviews with 30 youths aged 7–16 years after being admitted to a hospital follo... Read More about The journey back to normality: Support systems and posttrauma needs following exposure to single-incident trauma among children and adolescents.

A systematic literature review of the relationship between parenting responses and child post-traumatic stress symptoms (2022)
Journal Article

Background: Parents are a key source of support for children exposed to single-incident/acute traumas and can thereby play a potentially significant role in children’s post-trauma psychological adjustment. However, the evidence base examining parenta... Read More about A systematic literature review of the relationship between parenting responses and child post-traumatic stress symptoms.

International variation in evidence-based emergency department management of bronchiolitis: a retrospective cohort study (2022)
Journal Article

OBJECTIVES: We aimed to evaluate the international variation in the use of evidence-based management (EBM) in bronchiolitis. We hypothesised that management consistent with full-EBM practices is associated with the research network of care, adjusted... Read More about International variation in evidence-based emergency department management of bronchiolitis: a retrospective cohort study.

Incidence of traumatic brain injuries in head-injured children with seizures (2022)
Journal Article

Objective: Incidence and short-term outcomes of clinically important traumatic brain injury (ciTBI) in head-injured children presenting to ED with post-traumatic seizure (PTS) is not described in current literature. Methods: Planned secondary analysi... Read More about Incidence of traumatic brain injuries in head-injured children with seizures.

Educational interventions to prevent paediatric abusive head trauma in babies younger than one year old: A systematic review and meta-analyses (2022)
Journal Article

Background: Paediatric abusive head trauma (AHT) occurs in young children due to violent shaking or blunt impact. Educational and behavioural programmes modifying parent/infant interactions may aid primary prevention. This systematic review aims to a... Read More about Educational interventions to prevent paediatric abusive head trauma in babies younger than one year old: A systematic review and meta-analyses.

Paediatric major incident triage: A Delphi process to determine clinicians' attitudes and beliefs within the United Kingdom and Ireland (2022)
Journal Article

Aim: Triage is key to effective management of major incidents, yet there is scarce evidence surrounding the optimal method of paediatric major incident triage (MIT). This study aimed to derive consensus on key components of paediatric MIT among healt... Read More about Paediatric major incident triage: A Delphi process to determine clinicians' attitudes and beliefs within the United Kingdom and Ireland.

Features of the transposed seasonality of the 2021 RSV epidemic in the UK and Ireland: analysis of the first 10 000 patients (2022)
Journal Article

Non-pharmaceutical interventions (NPIs) introduced globally to limit the spread of SARS-CoV-2 led to disruption of the typical respiratory syncytial virus (RSV) seasonality.1 Studies examining the resurgence of RSV have been limited by sample size an... Read More about Features of the transposed seasonality of the 2021 RSV epidemic in the UK and Ireland: analysis of the first 10 000 patients.

Presentations of children to emergency departments across Europe and the COVID-19 pandemic: A multinational observational study (2022)
Journal Article

BACKGROUND: During the initial phase of the Coronavirus Disease 2019 (COVID-19) pandemic, reduced numbers of acutely ill or injured children presented to emergency departments (EDs). Concerns were raised about the potential for delayed and more sever... Read More about Presentations of children to emergency departments across Europe and the COVID-19 pandemic: A multinational observational study.