Thomas Waterfield
Seroprevalence of SARS-CoV-2 antibodies in children: A prospective multicentre cohort study
Waterfield, Thomas; Watson, Chris; Moore, Rebecca; Ferris, Kathryn; Tonry, Claire; Watt, Alison; McGinn, Claire; Foster, Steven; Evans, Jennifer; Lyttle, Mark David; Ahmad, Shazaad; Ladhani, Shamez; Corr, Michael; McFetridge, Lisa; Mitchell, Hannah; Brown, Kevin; Amirthalingam, Gayatri; Maney, Julie-Ann; Christie, Sharon
Authors
Chris Watson
Rebecca Moore
Kathryn Ferris
Claire Tonry
Alison Watt
Claire McGinn
Steven Foster
Jennifer Evans
Mark Lyttle mark.lyttle@uwe.ac.uk
Shazaad Ahmad
Shamez Ladhani
Michael Corr
Lisa McFetridge
Hannah Mitchell
Kevin Brown
Gayatri Amirthalingam
Julie-Ann Maney
Sharon Christie
Contributors
Mark Lyttle mark.lyttle@uwe.ac.uk
Project Member
Abstract
Background: Studies based on molecular testing of oral/nasal swabs underestimate SARS-CoV-2 infection due to issues with test sensitivity, test timing and selection bias. The objective of this study was to report the presence of SARS-CoV-2 antibodies, consistent with previous infection. Design: This multicentre observational cohort study, conducted between 16 April to 3 July 2020 at 5 UK sites, recruited children of healthcare workers, aged 2-15 years. Participants provided blood samples for SARS-CoV-2 antibody testing and data were gathered regarding unwell contacts and symptoms. Results: 1007 participants were enrolled, and 992 were included in the final analysis. The median age of participants was 10·1 years. There were 68 (6.9%) participants with positive SARS-CoV-2 antibody tests indicative of previous SARS-CoV-2 infection. Of these, 34/68 (50%) reported no symptoms prior to testing. The presence of antibodies and the mean antibody titre was not influenced by age. Following multivariable analysis four independent variables were identified as significantly associated with SARS-CoV-2 seropositivity: known infected household contact OR=10.9 (95% CI 6.1 to 19.6); fatigue OR=16.8 (95% CI 5.5 to 51.9); gastrointestinal symptoms OR=6.6 (95% CI 3.0 to 13.8); and changes in sense of smell or taste OR=10.0 (95% CI 2.4 to 11.4). Discussion: Children demonstrated similar antibody titres in response to SARS-CoV-2 irrespective of age. Fatigue, gastrointestinal symptoms and changes in sense of smell or taste were the symptoms most strongly associated with SARS-CoV-1 antibody positivity. Trial registration number: https://www.clinicaltrials.gov (trial registration: NCT0434740) on the 15 April 2020.
Journal Article Type | Article |
---|---|
Acceptance Date | Oct 12, 2020 |
Online Publication Date | Nov 10, 2020 |
Publication Date | 2021 |
Deposit Date | Mar 31, 2021 |
Publicly Available Date | Mar 31, 2021 |
Journal | Archives of Disease in Childhood |
Print ISSN | 0003-9888 |
Electronic ISSN | 1468-2044 |
Publisher | BMJ Publishing Group |
Peer Reviewed | Peer Reviewed |
Volume | 106 |
Issue | 7 |
Pages | 680-686 |
DOI | https://doi.org/10.1136/archdischild-2020-320558 |
Keywords | Pediatrics, Perinatology, and Child Health |
Public URL | https://uwe-repository.worktribe.com/output/7243852 |
Files
Seroprevalence of SARS-CoV-2 antibodies in children: a prospective multicentre cohort study
(438 Kb)
PDF
Licence
http://creativecommons.org/licenses/by-nc/4.0/
Publisher Licence URL
http://www.rioxx.net/licenses/all-rights-reserved
Copyright Statement
This article has been accepted for publication in Archives of Disease in Childhood, 2020, following peer review, and the Version of Record can be accessed online at https://doi.org/10.1136/archdischild-2020-320558.
Seroprevalence of SARS-CoV-2 antibodies in children: A prospective multicentre cohort study
(69 Kb)
Document
Licence
http://creativecommons.org/licenses/by-nc/4.0/
Publisher Licence URL
http://www.rioxx.net/licenses/all-rights-reserved
Copyright Statement
This article has been accepted for publication in Archives of Disease in Childhood, 2020, following peer review, and the Version of Record can be accessed online at https://doi.org/10.1136/archdischild-2020-320558.
You might also like
Trends in admission and death rates due to paediatric head injury in England, 2000-2011
(2015)
Journal Article
Assessing the impacts of the first year of rotavirus vaccination in the United Kingdom
(2015)
Journal Article
Downloadable Citations
About UWE Bristol Research Repository
Administrator e-mail: repository@uwe.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search