Outputs (22)

Identifying targetable metabolic dependencies across colorectal cancer progression (2024)
Journal Article

Colorectal cancer (CRC) is a multi-stage process initiated through the formation of a benign adenoma, progressing to an invasive carcinoma and finally metastatic spread. Tumour cells must adapt their metabolism to support the energetic and biosynthet... Read More about Identifying targetable metabolic dependencies across colorectal cancer progression.

Spliceosomal vulnerability of MYCN-amplified neuroblastoma is contingent on PRMT5-mediated regulation of epitranscriptomic and metabolomic pathways (2024)
Journal Article

Approximately 50% of poor prognosis neuroblastomas arise due to MYCN over-expression. We previously demonstrated that MYCN and PRMT5 proteins interact and PRMT5 knockdown led to apoptosis of MYCN amplified (MNA) neuroblastoma. Here we evaluate the hi... Read More about Spliceosomal vulnerability of MYCN-amplified neuroblastoma is contingent on PRMT5-mediated regulation of epitranscriptomic and metabolomic pathways.

Advances in cancer diagnosis and treatment (2024)
Journal Article

This Special Issue of the British Journal of Biomedical Science brings together a collection of articles which all contribute to the advancement of knowledge into the diagnosis and treatment of cancer. Each article in this diverse research field offe... Read More about Advances in cancer diagnosis and treatment.

IL-6 knockdown in a model of the human bone marrow, abrogates DNA damage induction in bystander cells post-chemotherapy induced cytokine release syndrome (2024)
Journal Article

Following infection or exposure to therapeutic agents, an aggressive immune response may result, termed cytokine storm (CS) or cytokine release syndrome. Here the innate immune system becomes uncontrolled, leading to serious consequences including po... Read More about IL-6 knockdown in a model of the human bone marrow, abrogates DNA damage induction in bystander cells post-chemotherapy induced cytokine release syndrome.

Healthcare professionals' knowledge, understanding and confidence to manage chronic pain after cancer treatment: A UK survey (2024)
Journal Article

Introduction: Healthcare professionals are vital in preparing people living with and beyond cancer about the risks of chronic pain after cancer treatment. To do so, healthcare professionals need to be knowledgeable and confident about chronic pain af... Read More about Healthcare professionals' knowledge, understanding and confidence to manage chronic pain after cancer treatment: A UK survey.

Anticancer effects of the Novel Pyrazolyl-Urea GeGe-3 (2024)
Journal Article

In a screen of over 200 novel pyrazole compounds, ethyl 1-(2-hydroxypentyl)-5-(3-(3-(trifluoromethyl) phenyl)ureido)-1H-pyrazole-4-carboxylate (named GeGe-3) has emerged as a potential anticancer compound. GeGe-3 displays potent anti-angiogenic prope... Read More about Anticancer effects of the Novel Pyrazolyl-Urea GeGe-3.

Patient experiences of brachytherapy for locally advanced cervical cancer: Hearing the patient voice through qualitative interviews (2023)
Journal Article

Purpose: Brachytherapy for gynecological cancer is reported to cause pain, anxiety, and distress with no clear guidance for optimizing patient experiences. The aim of this study was to explore patient experiences of brachytherapy and views on improve... Read More about Patient experiences of brachytherapy for locally advanced cervical cancer: Hearing the patient voice through qualitative interviews.

Evaluation of a live educational webinar on ‘Managing Chronic Pain’ (2023)
Presentation / Conference Contribution

1: Background
Chronic cancer-related pain (CRP) is frequently reported, yet poorly understood. It is essential healthcare professionals have knowledge and skills to support those impacted with chronic and late effect CRP. However, literature shows t... Read More about Evaluation of a live educational webinar on ‘Managing Chronic Pain’.

Evaluation of the impacts of patient and public involvement on cancer nursing doctoral study exploring cancer survivors’ experiences of living with chronic post cancer treatment pain (2023)
Presentation / Conference Contribution

Background. Patient and Public Involvement (PPI) can help shape research. It is important to capture the impacts that PPI have on cancer nursing doctoral research.
Methods: Two Public Contributors, who were cancer survivors living with chronic post... Read More about Evaluation of the impacts of patient and public involvement on cancer nursing doctoral study exploring cancer survivors’ experiences of living with chronic post cancer treatment pain.

Chronic post cancer treatment pain – how can we increase unity across pathways? (2023)
Presentation / Conference Contribution

Background: Chronic post cancer treatment pain is pain that persists or recurs for longer than three months and is caused by surgery, chemotherapy and/or radiotherapy . It can occur months or years after cancer treatment has finished. Limited knowl... Read More about Chronic post cancer treatment pain – how can we increase unity across pathways?.

Using the 'Evidencing Work Based Learning' module to improve the experience of people with cancer (2023)
Presentation / Conference Contribution

Gut bacteria promote proliferation in benign S/RG/C2 colorectal tumour cells, and promote proliferation, migration and invasion in malignant HCT116 cells (2023)
Journal Article

Colorectal cancer (CRC) is a significant global health burden with a rising incidence worldwide. Distinct bacterial populations are associated with CRC development and progression, and it is thought that the relationship between CRC and associated gu... Read More about Gut bacteria promote proliferation in benign S/RG/C2 colorectal tumour cells, and promote proliferation, migration and invasion in malignant HCT116 cells.

Long-term patient-reported outcomes of immediate breast reconstruction after mastectomy for breast cancer: Population-based cohort study (2023)
Journal Article

BACKGROUND: Breast reconstruction is offered to improve quality of life for women after mastectomy for breast cancer, but information regarding the long-term patient-reported outcomes of different reconstruction procedures is currently lacking. The B... Read More about Long-term patient-reported outcomes of immediate breast reconstruction after mastectomy for breast cancer: Population-based cohort study.

Development of online cancer resources to support pre-registration nurses and allied health professionals to increase their knowledge and understanding of cancer care (2023)
Journal Article

Cancer rates are increasing, and more people are living with cancer and its consequences. Healthcare students will be caring for people affected by cancer in all clinical contexts. However, pre-registration programmes can include limited cancer edu... Read More about Development of online cancer resources to support pre-registration nurses and allied health professionals to increase their knowledge and understanding of cancer care.

'I think it affects every aspect of my life, really': Cancer survivors' experience of living with chronic pain after curative cancer treatment in England, UK (2023)
Journal Article

Aim: To explore cancer survivors’ experiences of living with chronic pain after curative cancer treatment in England, UK. Methods: A qualitative study using telephone interviews with adult cancer survivors experiencing chronic pain after curative can... Read More about 'I think it affects every aspect of my life, really': Cancer survivors' experience of living with chronic pain after curative cancer treatment in England, UK.

Insulin-like growth factor binding protein-2 and glucose-regulated protein 78 kDa: Potential biomarkers affect prognosis in IDH-wildtype glioblastoma patients (2023)
Journal Article

Background: The overall survival of IDH-wildtype glioblastoma patients is poor despite best available treatments. There is an urgent need for new biomarkers to inform more precise disease stratification. Previous studies have identified insulin-like... Read More about Insulin-like growth factor binding protein-2 and glucose-regulated protein 78 kDa: Potential biomarkers affect prognosis in IDH-wildtype glioblastoma patients.

The impact of hegemonic masculine ideals on self-esteem in prostate cancer patients undergoing androgen deprivation therapy (ADT) compared to ADT-naïve patients (2022)
Journal Article

Purpose: Androgen deprivation therapy (ADT) for Prostate Cancer (PCa) is associated with side effects that could lead to negative body image and low masculine self-esteem of survivors. We compared a group of PCa survivors following ADT with ADT-naïve... Read More about The impact of hegemonic masculine ideals on self-esteem in prostate cancer patients undergoing androgen deprivation therapy (ADT) compared to ADT-naïve patients.

Exploring the experiences and psychosocial support needs of informal carers of men with breast cancer: A qualitative study (2022)
Journal Article

Purpose: The provision of practical and emotional support for men who have been diagnosed with breast cancer in the UK falls primarily on their partners, close family members or friends. However, informal carers’ experiences are omitted from the rese... Read More about Exploring the experiences and psychosocial support needs of informal carers of men with breast cancer: A qualitative study.

Fluorescence-activated cell sorting and quantitative real-time PCR to reveal VEGF-expressing macrophage populations in the Zebrafish larvae (2022)
Book Chapter

The transparent, genetically tractable zebrafish is increasingly recognized as a useful model to both live image and uncover mechanistic insight into cell interactions governing tissue homeostasis, pathology, and regeneration. Here, we describe a pro... Read More about Fluorescence-activated cell sorting and quantitative real-time PCR to reveal VEGF-expressing macrophage populations in the Zebrafish larvae.

Primary mesenchymal stromal cells in co-culture with leukaemic HL-60 cells are sensitised to cytarabine-induced genotoxicity, while leukaemic cells are protected (2021)
Journal Article

Tumour microenvironments are hallmarked in many cancer types. In haematological malignancies, bone marrow (BM) mesenchymal stromal cells (MSC) protect malignant cells from drug-induced cytotoxicity. However, less is known about malignant impact on su... Read More about Primary mesenchymal stromal cells in co-culture with leukaemic HL-60 cells are sensitised to cytarabine-induced genotoxicity, while leukaemic cells are protected.