All Outputs (129)

Reactivity prediction in aza-Michael additions without transition state calculations: The Ames test for mutagenicity (2020)
Journal Article

Animal testing remains a contentious ethical issue in predictive toxicology. Thus, a fast, versatile, low-cost quantum chemical model is presented for predicting the risk of Ames mutagenicity in a series of 1,4 Michael acceptor type compounds. This f... Read More about Reactivity prediction in aza-Michael additions without transition state calculations: The Ames test for mutagenicity.

Interaction between leukaemic cells and the bone marrow stroma (2020)
Thesis

Mesenchymal stromal cells (MSC) enhance growth and protect leukaemic cells from drug-induced toxicity in the bone marrow microenvironment (BMM), however, these interactions are not fully understood and less is known about the impact of leukaemic cell... Read More about Interaction between leukaemic cells and the bone marrow stroma.

The Ring-necked Parakeet Psittacula krameri in Wales: A preliminary review of records (2020)
Journal Article

The Ring-necked Parakeet is a widespread and invasive species with feral populations across the world. The feral population in Britain is expanding its distribution, with increasing numbers of sightings in Wales. There were 511 recorded sightings of... Read More about The Ring-necked Parakeet Psittacula krameri in Wales: A preliminary review of records.

An up-date on Covid-19 and animals: Ones which have been shown to be susceptible, and related welfare issues (2020)
Other

WT1 activates transcription of the splice factor kinase SRPK1 gene in PC3 and K562 cancer cells in the absence of corepressor BASP1 (2020)
Journal Article

Dysregulated alternative splicing plays a prominent role in all hallmarks of cancer. The splice factor kinase SRPK1 drives the activity of oncogenic splice factors such as SRSF1. SRSF1 in turn promotes the expression of splice isoforms that favour tu... Read More about WT1 activates transcription of the splice factor kinase SRPK1 gene in PC3 and K562 cancer cells in the absence of corepressor BASP1.

From orphan phage to a proposed new family–the diversity of N4-like viruses (2020)
Journal Article

Escherichia phage N4 was isolated in 1966 in Italy and has remained a genomic orphan for a long time. It encodes an extremely large virion-associated RNA polymerase unique for bacterial viruses that became characteristic for this group. In recent yea... Read More about From orphan phage to a proposed new family–the diversity of N4-like viruses.

Water scarcity communication in the UK: Learning from water company communications following the 2018 heatwave (2020)
Journal Article

When communicating about water scarcity, public water companies in the UK operate within a fine balance. There is a legal obligation on water companies in the UK to promote efficient water use, and pressure on water resources means that water compani... Read More about Water scarcity communication in the UK: Learning from water company communications following the 2018 heatwave.

A step-by-step method for producing 3D crania models from CT data (2020)
Journal Article

Objectives: Modern computed tomography (CT) databases offer a valuable resource for obtaining skeletal reconstructions and contemporary population data. However, researchers may not utilise CT data due to limited funds for proprietary modelling softw... Read More about A step-by-step method for producing 3D crania models from CT data.

The role of hBCATc in breast cancer progression through IGF-1 and insulin signalling cascades (2020)
Thesis

Introduction and Aims:

Breast cancer remains the leading cause of cancer mortality in women globally, despite advances in the development of targeted therapies. Driven by oncogenic signals, cancer cells undergo metabolic reprogramming, upregulatin... Read More about The role of hBCATc in breast cancer progression through IGF-1 and insulin signalling cascades.

A feasibility randomised controlled trial of a fibromyalgia self-management programme in a community setting with a nested qualitative study (FALCON): Study protocol (2020)
Journal Article

Background: Fibromyalgia (FM) is a complex long-term condition associated with chronic widespread pain, fatigue, sleep problems, memory and concentration difficulties and irritable bowel syndrome. Current guidelines for the treatment of FM recommend... Read More about A feasibility randomised controlled trial of a fibromyalgia self-management programme in a community setting with a nested qualitative study (FALCON): Study protocol.

In vitro antifungal activity of Cinnamomum zeylanicum bark and leaf essential oils against Candida albicans and Candida auris (2020)
Journal Article

Candida infections are a significant source of patient morbidity and mortality. Candida albicans is the most common pathogen causing Candida infections. Candida auris is a newly described pathogen that is associated with multi-drug-resistant candidia... Read More about In vitro antifungal activity of Cinnamomum zeylanicum bark and leaf essential oils against Candida albicans and Candida auris.

Hydrogenases and the role of molecular hydrogen in plants (2020)
Journal Article

Molecular hydrogen (H2) has been suggested to be a beneficial treatment for a range of species, from humans to plants. Hydrogenases catalyze the reversible oxidation of H2, and are found in many organisms, including plants. One of the cellular effect... Read More about Hydrogenases and the role of molecular hydrogen in plants.

A collaborative, user-based approach to developing science communication resources using Minecraft (2020)
Journal Article

Phosphorylation of Syntaxin‐1a by casein kinase 2α (CK2α) regulates presynaptic vesicle exocytosis from the reserve pool (2020)
Journal Article

The t-soluble NSF-attachment protein receptor protein Syntaxin-1a (Stx-1a) is abundantly expressed at pre-synaptic terminals where it plays a critical role in the exocytosis of neurotransmitter-containing synaptic vesicles. Stx-1a is phosphorylated... Read More about Phosphorylation of Syntaxin‐1a by casein kinase 2α (CK2α) regulates presynaptic vesicle exocytosis from the reserve pool.

Estragole: DNA adduct formation in primary rat hepatocytes and genotoxic potential in HepG2-CYP1A2 cells (2020)
Journal Article

Estragole is a natural constituent in herbs and spices and in products thereof such as essential oils or herbal teas. After cytochrome P450-catalyzed hydroxylation and subsequent sulfation, estragole acts as a genotoxic hepatocarcinogen forming DNA a... Read More about Estragole: DNA adduct formation in primary rat hepatocytes and genotoxic potential in HepG2-CYP1A2 cells.

Illicit drug contamination of the Bristol Pound local currency (2020)
Journal Article

Reports have shown the prevalence of the contamination of banknotes with a number of different drugs. These studies have focused on investigating drug contamination levels on currency which is either nationally or even international distributed. To p... Read More about Illicit drug contamination of the Bristol Pound local currency.

The utility of three-dimensional models of paranasal sinuses to establish age, sex, and ancestry across three modern populations: A preliminary study (2020)
Journal Article

Technological advances have furthered the development and understanding of trace materials such that DNA and fingerprints have become the foundation of human identification. However, when a body undergoes damage such as in cases of arson, these metho... Read More about The utility of three-dimensional models of paranasal sinuses to establish age, sex, and ancestry across three modern populations: A preliminary study.

Clusterin secretion is attenuated by the proinflammatory cytokines interleukin-1β and tumor necrosis factor-α in models of cartilage degradation (2020)
Journal Article

The protein clusterin has been implicated in the molecular alterations that occur in articular cartilage during osteoarthritis (OA). Clusterin exists in two isoforms with opposing functions, and their roles in cartilage have not been explored. The se... Read More about Clusterin secretion is attenuated by the proinflammatory cytokines interleukin-1β and tumor necrosis factor-α in models of cartilage degradation.

Hydrogen sulfide in horticulture: Emerging roles in the era of climate change (2020)
Journal Article

Future climate change will present many plants with environmental challenges, including extreme temperatures and drought. Hydrogen sulfide (H2S) has emerged as an important signal transmitting molecule in plants, especially important in many stress r... Read More about Hydrogen sulfide in horticulture: Emerging roles in the era of climate change.

An improved conjugation method for Pseudomonas syringae (2020)
Journal Article

In order to achieve saturating transposon mutagenesis of the genome of plant pathogenic strains of Pseudomonas syringae we needed to improve plasmid conjugation frequency. Manipulation of the growth stage of donor and recipient cells allowed the requ... Read More about An improved conjugation method for Pseudomonas syringae.