What outcome measures are commonly used for Complex Regional Pain Syndrome clinical trials? A systematic review of the literature

McCabe, C.; Walsh, N.; Jones, L.; Grieve, S.; Grieve, Sharon; Walsh, Nicola; McCabe, Candy

Abstract

© 2015 European Pain Federation - EFIC®. Background and objective Complex Regional Pain Syndrome (CRPS) is a chronic pain condition, often triggered by trauma to a limb and characterized by sensory, motor, autonomic and trophic changes within the affected limb. Due to the multi-faceted nature of the condition there are a wide range of potential health outcome measures for use within CRPS related clinical trials. This aim of this systematic literature review was to identify which patient or health professional questionnaire format outcome measures have been used in CRPS specific clinical trials, and which of these have been developed specifically for use in CRPS populations. Information gained from this review will inform an international consortium project to define a Core Outcome measurement set for CRPS Clinical trials. Databases and data treatment The electronic databases EMBASE, Medline, PsycInfo, CINAHL and LILACS were systematically searched from January 2000 until April 2014. Results One hundred and four full text papers were obtained with 68 questionnaire outcome measures identified. Five of these outcome measures were validated for CRPS. Of those outcome measures used since 2000, those addressing physical functioning were most prevalent. Conclusions Currently, CRPS clinical trials use a wide range of outcome measures making the potential to synthesize evidence problematic. There is no internationally agreed core measurement set. This diversity of outcome measures demonstrates a clear need for the development of a core measurement set to be used in CRPS clinical trials.

• Journal Article Type: Article
• Online Publication Date: Jun 15, 2015
• Publication Date: Mar 1, 2016
• Deposit Date: Jun 23, 2015
• Publicly Available Date: Jun 15, 2016
• Journal: European Journal of Pain (United Kingdom)
• Print ISSN: 1090-3801
• Electronic ISSN: 1532-2149
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 20
• Issue: 3
• Pages: 331-340
• DOI: https://doi.org/10.1002/ejp.733
• Keywords: CRPS, pain
• Public URL: https://uwe-repository.worktribe.com/output/911292
• Publisher URL: http://dx.doi.org/10.1002/ejp.733
• Additional Information: Additional Information : This is the peer reviewed version of the following article: Grieve, S., Jones, L., Walsh, N. and McCabe, C. (2015) What outcome measures are commonly used for Complex Regional Pain Syndrome clinical trials? A systematic review of the literature. European Journal of Pain. 20 (3), pp.331-340. ISSN 1090-3801, which has been published in final form at http://dx.doi.org/10.1002/ejp.733. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
• Contract Date: Mar 22, 2016